Note. Venues and Kick off times are always difficult for pre-season games. Where none is known, the venue is assumed as the home team ground and the kick off is assumed as 3.00pm for a weekend game and 7.30pm for a midweek game. Please check these details with the home club before you travel to a particular game.
| Friday 17th June 2022 | |||||
| 19:45 | Burnley United | 1-5 | Padiham | Barden Sports Ground | |
| Saturday 18th June 2022 | |||||
| 14:30 | FC United of Wrexham | 0-7 | Ashville | Bronwen Green | |
| Wednesday 22nd June 2022 | |||||
| 19:45 | Darwen FC | 0-3 | Longridge Town | WEC Group Anchor Ground | |
| Friday 24th June 2022 | |||||
| 19:45 | Garstang | 0-2 | Longridge Town | The Riverside | |
| Saturday 25th June 2022 | |||||
| 15:00 | Bolton United | 1-2 | Prestwich Heys | Barlow Park | |
| 12:00 | Macclesfield U18 | 0-1 | Atherton LR | The Leasing.com Stadium | |
| 15:00 | Pilkington | 4-3 | Sandbach United | The Arcoframe Stadium | |
| Tuesday 28th June 2022 | |||||
| 19:45 | Darwen FC | 0-6 | Blackburn Rovers XI | WEC Group Anchor Ground | |
| 19:00 | Euxton Villa | 1-4 | Chorley | Jim Fowler Memorial Ground | |
| 19:45 | Longridge Town | 0-9 | Bolton Wanderers | The Recycling Lives Ground | |
| Friday 1st July 2022 | |||||
| 19:45 | Bacup Borough | 3-1 | Avro | Brian Boys West View Stadium | |
| 19:30 | Eccleshall | 0-2 | Hanley Town | Pershall Park | |
| 19:00 | Euxton Villa | 3-0 | Bootle | Jim Fowler Memorial Ground | |
| 19:30 | Lower Breck | 4-1 | Sefton Athletic | Anfield Sports Community Centre | |
| Saturday 2nd July 2022 | |||||
| 15:00 | Abbey Hulton United | 2-1 | Congleton Town | Drayton Beaumont Park | |
| 15:00 | Barnton | 3-1 | City of Liverpool | Townfield | |
| 14:00 | Blackpool Wren Rovers | 0-0 | Prestwich Heys | Bruce Park | |
| 15:00 | Burscough Richmond | 0-5 | Pilkington | JMO Sports Park | |
| 15:00 | Cefn Druids | 0-1 | AFC Liverpool | The Rock | |
| 14:00 | Chadderton | 3-5 | Padiham | The Falcon Fire Stadium | |
| 15:00 | Cheadle Heath Nomads | 2-1 | Cheadle Heath Nomads Res | The Heath | |
| 15:00 | Cheadle Town | 2-1 | Winsford United | Park Road Stadium | |
| 15:00 | CMB | 2-1 | Ashton Athletic | New Tempest Road | |
| 15:00 | Egerton | 1-2 | Atherton LR | Mereheath Lane | |
| 18:30 | FC Isle of Man | 2-1 | Nostell Miners Welfare | The Bowl | |
| 12:30 | FC St Helens | 3-2 | Newton | Sutton Leisure 3G | |
| 15:00 | Hindsford | 4-5 | Sandbach United | Squires Lane | |
| 13:00 | Holker Old Boys | 1-3 | Barrow | The Handmark Engineering Stadium | |
| 15:00 | Ilkley Town | 1-0 | Thackley | MPM Stadium | |
| 15:00 | Llandudno | 3-4 | Northwich Victoria | Maesdu Park | |
| 15:00 | Longridge Town | 1-3 | Macclesfield | The Recycling Lives Ground | |
| 15:00 | Lostock St Gerrards | 1-2 | Darwen FC | Wateringpool Lane | |
| 15:00 | Maine Road | 3-3 | Denton Town | Wright Robinson College | |
| 15:00 | New Mills | 0-3 | Curzon Ashton | Church Lane | |
| 15:00 | Rocester | 2-3 | Stoke City U18 | Hillsfield | |
| Don Hill Cup | |||||
| 15:00 | Runcorn Sports | 2-2 | Ashton Town | Runcorn Sports Club | |
| 15:00 | South Liverpool | 8-0 | Capenhurst Villa | North Field | |
| 15:00 | Squires Gate | 0-2 | Nelson | The Brian Addison Stadium | |
| 15:00 | Stafford Town | 2-0 | Stafford Rangers | Evans Park | |
| 13:00 | Steeton | P-P | Barnoldswick Town | Marley Stadium | |
| 14:30 | Stockport Georgians | 1-5 | Wythenshawe Town | Seashells 3G pitch | |
| 15:00 | Stockport Town | 0-4 | Bury AFC | Stockport Sports Village | |
| 15:00 | Thornton Cleveleys | 1-5 | Kendal Town | Myerscough College | |
| 15:00 | Vauxhall Motors | 5-2 | Widnes | The vanEupen Arena | |
| 15:00 | Warstone Wanderers | 1-2 | Brocton | Penkridge Recreation Centre | |
| 14:00 | Wythenshawe Amateurs | 3-2 | Daisy Hill | Manchester Health Academy | |
| Monday 4th July 2022 | |||||
| 19:30 | Stockport Town | 2-1 | Winsford United | Stockport Sports Village | |
| Tuesday 5th July 2022 | |||||
| 19:45 | Atherton Collieries | 3-1 | Bury AFC | The Kensite Stadium | |
| 19:45 | Bacup Borough | 2-4 | Chorley | Brian Boys West View Stadium | |
| 19:00 | Brocton | 1-1 | AFC Wulfrunians | Silkmore Lane Sports Ground | |
| 19:45 | Cheadle Heath Nomads | 1-1 | Wythenshawe Town | The Heath | |
| 19:15 | Coppull United | 1-2 | Northwich Victoria | Blainscough Park | |
| George Melling Memorial Trophy | |||||
| 19:30 | Eccleshall | 0-1 | Newcastle Town | Pershall Park | |
| 19:30 | Ellesmere Rangers | 3-2 | Cefn Druids | Beech Grove Stadium | |
| 19:30 | Ilkley Town | 1-5 | Knareborough Town | MPM Stadium | |
| 19:30 | Longridge Town | P-P | FC United of Manchester | The Recycling Lives Ground | |
| 19:45 | Sandbach United | 0-1 | Atherton LR | Sandbach Community Football Centre | |
| 19:45 | Silsden | 0-1 | Nelson | The Cobbydale Construction Stadium | |
| 19:15 | Tintwistle Athletic | 0-5 | Cheadle Town | West Drive Football Centre | |
| 19:30 | Vauxhall Motors | 3-2 | Ashton Town | The vanEupen Arena | |
| 19:00 | Whitehaven Amateurs | 0-5 | Cleator Moor Celtic | County Ground | |
| Wednesday 6th July 2022 | |||||
| 19:30 | Alsager Town | 1-4 | Macclesfield XI | Woodpark Stadium | |
| 19:30 | Avro | 1-1 | Radcliffe | Vestacare Stadium | |
| 19:30 | CMB | 1-5 | Euxton Villa | New Tempest Road | |
| 19:00 | Croston Sports | 0-5 | Barnoldswick Town | Croston Sports Club | |
| 19:30 | Garstang | 3-1 | Squires Gate | The Riverside | |
| 19:30 | Kendal Town | 0-9 | Carlisle United | J Robs Ground Maintenance Stadium | |
| 19:30 | Rocester | 4-1 | Port Vale u18 | Hillsfield | |
| Supporters Cup | |||||
| 19:30 | Thornton Cleveleys | 1-2 | Padiham | Poolfoot Farm | |
| 15:00 | Wellington Amateurs | 0-3 | Stafford Town | School Grove | |
| Friday 8th July 2022 | |||||
| 19:30 | Abbey Hulton United | 0-0 | Kidsgrove Athletic | Drayton Beaumont Park | |
| 19:45 | Buckley Town | 0-2 | AFC Liverpool | Globe Way | |
| 18:30 | FC St Helens | 1-2 | Wythenshawe Amateurs | Windleshaw Sports Ground | |
| 19:00 | Fulwood Amateurs | 4-3 | AFC Blackpool | ||
| 19:00 | Holker Old Boys | 5-2 | Vickerstown | The Handmark Engineering Stadium | |
| Saturday 9th July 2022 | |||||
| 15:00 | Alsager Town | 0-2 | Congleton Town | Woodpark Stadium | |
| 15:00 | Avro | 3-0 | Daisy Hill | Vestacare Stadium | |
| 15:00 | Barnton | 1-1 | Witton Albion | Townfield | |
| 13:00 | Brocton | 2-2 | Walsall Wood | Silkmore Lane Sports Ground | |
| 15:00 | Cammell Laird 1907 | 0-2 | City of Liverpool | Prabhu Ventures Ltd Arena | |
| 15:00 | Carlisle City | 3-1 | Cleator Moor Celtic | The Don Marks Carpets Stadium | |
| 14:00 | Caton United | 1-8 | Kendal Town | Caton Sports Field | |
| 15:00 | Charnock Richard | 1-5 | Chorley | Mossie Park | |
| 15:00 | Cheadle Heath Nomads | 5-2 | Ashton Athletic | The Heath | |
| 14:00 | Cheadle Town | 0-2 | Stephen Ireland XI | Park Road Stadium | |
| 15:00 | Eccleshall | 2-2 | Altrincham XI | Pershall Park | |
| 15:00 | Egerton | 2-5 | Irlam | Mereheath Lane | |
| 14:30 | Euxton Villa | 4-1 | Stockport Georgians | Jim Fowler Memorial Ground | |
| 18:30 | FC Isle of Man | 0-1 | Widnes | The Bowl | |
| 14:00 | Garstang | 6-0 | Poulton | The Riverside | |
| 15:00 | Guiseley | 3-1 | Bury AFC | Nethermoor Park | |
| 13:00 | Helsby | 3-5 | Runcorn Town | Helsby Community Sports Centre | |
| 15:00 | Hyde United | 2-3 | Stockport Town | Ewen Fields | |
| 15:00 | Longridge Town | 1-3 | Blackpool | The Recycling Lives Ground | |
| 13:00 | Lower Breck | 2-0 | Chadderton | Anfield Sports Community Centre | |
| 15:00 | Maghull | 1-1 | South Liverpool | Old Hall Field | |
| 15:00 | MSB Woolton | 2-1 | Ashton Town | Simpsons Ground | |
| 13:00 | Nelson | 1-2 | Hurst Green | Little Wembley | |
| 15:00 | Newton Aycliffe | 1-1 | Abbey Hey | Moore Lane Sports Club Ground | |
| 15:00 | Northwich Victoria | 1-1 | Matlock Town | Wincham Park | |
| 15:00 | Otley Town | 0-6 | Ilkley Town | The Old Showground | |
| 15:00 | Pilkington | 3-3 | Conwy Borough | The Arcoframe Stadium | |
| 13:00 | Prestwich Heys | 3-0 | Ramsbottom United | Adie Moran Park | |
| 15:00 | Rossendale | 3-5 | Barnoldswick Town | Marl Pits Sports Centre | |
| 15:00 | Squires Gate | 1-1 | Colne | The Brian Addison Stadium | |
| 15:00 | Stafford Town | 0-1 | Lye Town | Evans Park | |
| 15:00 | Steeton | 3-1 | Heyside | Marley Stadium | |
| 15:00 | Trafford | 3-0 | Maine Road | Shawe View | |
| 15:00 | Vauxhall Motors | 2-3 | Marine | The vanEupen Arena | |
| 12:00 | West Didsbury & Chorlton | 2-0 | Altrincham XI | Step Places Stadium | |
| 14:00 | Winnington Avenue 94 | 3-0 | Atherton LR | Park Stadium | |
| 15:00 | Winsford United | 2-0 | New Mills | Barton Stadium | |
| 15:30 | Wythenshawe Town | 2-2 | Altrincham XI | Ericstan Park | |
| Sunday 10th July 2022 | |||||
| 14:00 | Padiham | 1-0 | Clitheroe | Ruby Civil Arena | |
| Monday 11th July 2022 | |||||
| 19:30 | Prestwich Heys | 6-2 | Eagley | Adie Moran Park | |
| 19:30 | Stockport Town | 1-0 | West Didsbury & Chorlton | Stockport Sports Village | |
| Tuesday 12th July 2022 | |||||
| 19:45 | Abbey Hey | 2-3 | Radcliffe | The Abbey Stadium | |
| 19:30 | Abbey Hulton United | 2-1 | Hanley Town | Drayton Beaumont Park | |
| 19:45 | Alsager Town | 1-2 | Market Drayton Town | Woodpark Stadium | |
| 19:30 | Ball Haye Green | 0-4 | Eccleshall | Pointon Park | |
| 19:30 | Barnoldswick Town | 2-5 | Clitheroe | Silentnight Stadium | |
| 19:30 | Barnton | 6-1 | Middlewich Town | Townfield | |
| Terry Murphy Memorial Cup | |||||
| 19:00 | Brocton | 3-1 | Stone Old Alleynians | Silkmore Lane Sports Ground | |
| 18:30 | Burnley Belvedere | 1-2 | Chadderton | Belvedere Ground | |
| 19:45 | Charnock Richard | 8-1 | Winstanley Warriors | Mossie Park | |
| 19:45 | Cheadle Heath Nomads | 0-0 | Northwich Victoria | The Heath | |
| 19:30 | CMB | 2-1 | Daisy Hill | New Tempest Road | |
| 19:45 | Congleton Town | 2-1 | Leek Town | The Cleric Stadium | |
| 19:30 | Ellesmere Port Town | 2-1 | Atherton LR | Whitby Sports Club | |
| 19:30 | Ellesmere Rangers | 1-3 | Shawbury United | Beech Grove Stadium | |
| 19:00 | Euxton Villa | 0-0 | Chester XI | Jim Fowler Memorial Ground | |
| 19:45 | FC United of Manchester | 4-2 | Bury AFC | Broadhurst Park | |
| 18:45 | Foley Meir | 2-2 | Newcastle Town | McIntosh Arena | |
| 19:00 | Padiham | 2-1 | Burnley U18 | Ruby Civil Arena | |
| 19:30 | Runcorn Town | 2-2 | Squires Gate | Viridor Community Stadium | |
| 19:00 | Slyne with Hest | 2-3 | Kendal Town | Bottomdale Road | |
| 19:45 | South Liverpool | 2-4 | Lower Breck | Jericho Lane | |
| 19:00 | Stockport Georgians | 5-2 | Burscough | Cromley Road | |
| 19:30 | Vauxhall Motors | 1-3 | Colwyn Bay | The vanEupen Arena | |
| 19:45 | Winsford United | 2-2 | 1874 Northwich | Barton Stadium | |
| Wednesday 13th July 2022 | |||||
| 19:30 | Darwen FC | 3-4 | Rossendale | WEC Group Anchor Ground | |
| 19:45 | Garstang | 4-2 | Lostock St Gerards | The Riverside | |
| 18:45 | Prestwich Heys | 3-2 | Walshaw Sports | St Annes Field (Tottington United) | |
| St Annes Cup | |||||
| Thursday 14th July 2022 | |||||
| 19:00 | AFC Liverpool | 2-2 | Cammell Laird 1907 | St John Bosco 3G | |
| 19:30 | Ilkley Town | 2-1 | Horbury Town | MPM Stadium | |
| 19:30 | Longridge Town | 3-2 | Preston North End XI | The Recycling Lives Ground | |
| 19:45 | Nelson | 1-1 | Ramsbottom United | Little Wembley | |
| Friday 15th July 2022 | |||||
| 19:45 | Congleton Town | 1-0 | Kidsgrove Athletic | The Cleric Stadium | |
| 19:30 | Daisy Hill | 4-1 | Ashton United | New Sirs | |
| Saturday 16th July 2022 | |||||
| 15:00 | Abbey Hey | 0-6 | Hyde United | The Abbey Stadium | |
| 15:00 | AFC Blackpool | 3-3 | Northwich Victoria | Mechanics Ground | |
| 14:00 | AFC Knowsley | P-P | Ashville | ||
| 15:00 | Allscott Heath | 2-1 | Foley Meir | Allscott Sports & Social Club | |
| 15:00 | Ashington | 0-1 | Charnock Richard | Woodhorn Lane | |
| 15:00 | Ashton Town | 1-1 | Ashton Athletic | Hebs Group Stadium | |
| Ashton Town won 4-2 on penalties. Taffy Pomfrett Trophy. | |||||
| 15:00 | Avro | 2-2 | Mossley | Vestacare Stadium | |
| 15:00 | Bacup Borough | 0-0 | Winsford United | Brian Boys West View Stadium | |
| 15:00 | Barnoldswick Town | 1-1 | Colne | Silentnight Stadium | |
| 15:00 | Brereton Social | 0-4 | Rocester | Red Lion Ground | |
| 15:00 | Brocton | 1-0 | Heath Hayes | Silkmore Lane Sports Ground | |
| 15:00 | Cammell Laird 1907 | 0-1 | Warrington Rylands | Prabhu Ventures Ltd Arena | |
| 15:00 | Cheadle Heath Nomads | 0-5 | 1874 Northwich | The Heath | |
| 15:00 | Cheadle Town | 2-1 | Denton Town | Park Road Stadium | |
| 14:30 | Conwy Borough | 0-3 | West Didsbury & Chorlton | Y Morfa Stadium | |
| 15:00 | Darwen FC | P-P | Euxton Villa | WEC Group Anchor Ground | |
| 15:00 | FC Isle of Man | 1-5 | Altrincham | The Bowl | |
| 18:30 | FC Isle of Man | 0-4 | Shifnal Town | The Bowl | |
| 13:00 | FC St Helens | 9-0 | Sefton Athletic | Windleshaw Sports Ground | |
| 15:00 | Haddington Athletic | 3-3 | Garstang | Pennypit Park | |
| 15:00 | Kendal Town | 1-2 | Carlisle City | J Robs Ground Maintenance Stadium | |
| 15:00 | Leek CSOB | 2-3 | Sandbach United | Pointon Park | |
| 15:00 | Llangollen Town | 0-11 | Barnton | Runcorn Sports Club | |
| 15:00 | Longridge Town | 1-6 | Bamber Bridge | The Recycling Lives Ground | |
| 15:00 | Lostock Gralam | 2-0 | Alsager Town | Park Stadium | |
| 13:00 | Lower Breck | 6-1 | Bootle | Anfield Sports Community Centre | |
| 15:00 | Maine Road | 3-2 | Pilkington | Wright Robinson College | |
| 14:00 | Nelson | 1-0 | AFC Liverpool | Little Wembley | |
| 15:00 | New Mills | 2-4 | Trafford | Church Lane | |
| 15:00 | Ramsbottom United | 1-0 | Bury AFC | Riverside Ground | |
| 15:00 | Runcorn Town | 1-1 | Abbey Hulton United | Viridor Community Stadium | |
| 15:00 | South Liverpool | 1-0 | Litherland Remyca | Jericho Lane | |
| 15:00 | Squires Gate | 2-4 | Radcliffe | The Brian Addison Stadium | |
| 15:00 | St Helens Town | 1-3 | Atherton LR | Arcoframe Stadium | |
| 14:00 | Stafford Town | 0-2 | Chadderton | Evans Park | |
| 15:00 | Steeton | 1-4 | Silsden | Marley Stadium | |
| 15:00 | Stockport Georgians | 0-0 | Royton Town | Cromley Road | |
| 15:00 | Stockport Town | 2-2 | Runcorn Linnets | Stockport Sports Village | |
| 15:00 | Vauxhall Motors | 1-2 | Ruthin Town | The vanEupen Arena | |
| 15:00 | Whitchurch Alport | P-P | Prestwich Heys | KMJ Mortgages Stadium | |
| 15:00 | Wolstanton United | 2-1 | Eccleshall | Bradwell Community Centre | |
| 15:00 | Wyre Villa | P-P | Holker Old Boys | ||
| 12:15 | Wythenshawe Amateurs | 0-4 | Irlam | Manchester Enterprise Academy | |
| 15:00 | Wythenshawe Town | 1-3 | Warrington Town | Ericstan Park | |
| The Simon James Trophy | |||||
| Tuesday 19th July 2022 | |||||
| 19:30 | Audley | P-P | Eccleshall | Town Fields | |
| 19:30 | Cammell Laird 1907 | 0-4 | Tranmere Rovers XI | Prabhu Ventures Ltd Arena | |
| 19:45 | Daisy Hill | 3-2 | Wythenshawe Town | New Sirs | |
| 19:30 | Egerton | P-P | Wythenshawe Amateurs | Mereheath Lane | |
| 19:30 | Garstang | 3-0 | Lancaster City | The Riverside | |
| 19:45 | Ilkley Town | P-P | Eccleshill United | MPM Stadium | |
| 19:30 | Kendal Town | 2-0 | Fleetwood Town XI | J Robs Ground Maintenance Stadium | |
| 19:30 | Northwich Victoria | P-P | City of Liverpool | Wincham Park | |
| 19:45 | South Liverpool | P-P | AFC Liverpool | Jericho Lane | |
| 19:45 | Squires Gate | 0-0 | Wren Rovers | The Brian Addison Stadium | |
| 19:30 | Tottington United | P-P | Atherton LR | St Annes Field | |
| 19:45 | Trafford | 2-0 | Bury AFC | Shawe View | |
| 19:30 | Vauxhall Motors | P-P | Witton Albion | The vanEupen Arena | |
| Wednesday 20th July 2022 | |||||
| 19:45 | Alsager Town | 2-0 | Port Vale XI | Woodpark Stadium | |
| 19:45 | Ashton Athletic | 0-4 | FC United of Manchester | Brocstedes Park | |
| Sam Harding Memorial Trophy | |||||
| 19:30 | Barnton | 0-2 | 1874 Northwich | Townfield | |
| 20:00 | Campion | 6-0 | Steeton | The Players Cars Stadium | |
| 19:30 | Ellesmere Rangers | 0-3 | Airbus UK Broughton | Beech Grove Stadium | |
| 19:00 | Euxton Villa | 1-0 | Runcorn Linnets | Jim Fowler Memorial Ground | |
| 19:30 | Runcorn Town | P-P | Skelmersdale United | Viridor Community Stadium | |
| 19:45 | Sandbach United | 1-0 | West Didsbury & Chorlton | Sandbach Community Football Centre | |
| 19:30 | Stapenhill | 3-2 | Rocester | Edge Hill Football Ground | |
| 19:00 | Whaley Bridge | 3-0 | Stockport Georgians | Park Road | |
| 19:45 | Winsford United | 3-0 | Nantwich Town | Barton Stadium | |
| Thursday 21st July 2022 | |||||
| 18:30 | Abbey Hey | 0-7 | Chadderton | The Abbey Stadium | |
| 20:00 | Abbey Hulton United | 3-2 | Newcastle Town | Drayton Beaumont Park | |
| 19:45 | AFC Bridgnorth | 0-1 | Stafford Town | Crown Meadow | |
| 19:00 | Brocton | 2-1 | Wolverhampton Casuals | Silkmore Lane Sports Ground | |
| 19:30 | Cheadle Town | 2-1 | Hyde United | Park Road Stadium | |
| 19:30 | Irlam | 0-1 | Mossley | The RG3 Digital Stadium | |
| 19:30 | New Mills | 1-1 | Ramsbottom United | Church Lane | |
| 19:00 | Silsden | 7-2 | Ilkley Town | The Cobbydale Construction Stadium | |
| Friday 22nd July 2022 | |||||
| 19:30 | Eccleshall | 2-5 | Congleton Town | Pershall Park | |
| 19:00 | FC St Helens | 4-1 | Rainhill Town | Windleshaw Sports Ground | |
| 19:15 | Johnstone Burgh | 1-1 | Nelson | Keanie Park | |
| Saturday 23rd July 2022 | |||||
| 15:00 | Abbey Hulton United | 5-0 | Rochdale Academy | Drayton Beaumont Park | |
| 15:00 | Barnoldswick Town | 2-2 | Fleetwood Town XI | Silentnight Stadium | |
| 15:00 | Barnton | 0-0 | Altrincham XI | Townfield | |
| 15:00 | Barrow Town | 4-3 | Stafford Town | Riverside Park | |
| 13:00 | Brigg Town | P-P | Avro | The EC Surfacing Stadium | |
| 15:00 | Brocton | 1-2 | Lye Town | Silkmore Lane Sports Ground | |
| 15:00 | Cammell Laird 1907 | 0-3 | Vauxhall Motors | Prabhu Ventures Ltd Arena | |
| 13:30 | Carlisle City | 3-4 | Nelson | The Don Marks Carpets Stadium | |
| 14:00 | Chadderton | 3-3 | Trafford | The Falcon Fire Stadium | |
| 15:00 | Cheadle Heath Nomads | 2-1 | Bury AFC | The Heath | |
| 15:00 | Cleator Moor Celtic | 3-3 | Crook Town | McGrath Park | |
| 15:00 | Coppull United | v | Atherton LR | Blainscough Park | |
| 15:00 | Daisy Hill | 1-3 | Radcliffe | New Sirs | |
| 15:00 | Darwen FC | 2-0 | Turton | WEC Group Anchor Ground | |
| Vizzard Memorial Trophy | |||||
| 18:00 | FC Isle of Man | 2-0 | Guernsey | The Bowl | |
| Skipton Cup | |||||
| 15:00 | Garstang | 7-2 | Cheadle Town | The Riverside | |
| 15:00 | Golcar United | 3-3 | Abbey Hey | Skye Direct Stadium | |
| 15:00 | Haslingden St Mary’s | 2-2 | Euxton Villa | St. Marys Ground | |
| 14:00 | Holker Old Boys | 1-3 | Longridge Town | The Handmark Engineering Stadium | |
| 15:00 | Kendal Town | 5-2 | Workington | J Robs Ground Maintenance Stadium | |
| 15:00 | Marine | 3-2 | AFC Liverpool | The Marine Travel Arena | |
| 15:00 | Marshalls | A-A | Ashville | IM Marsh Campus | |
| 15:00 | Nostell Miners Welfare | 1-3 | Ilkley Town | Crofton Community Centre | |
| 14:00 | Padiham | 0-2 | Colne | Ruby Civil Arena | |
| 15:00 | Penistone Church | 4-1 | Bacup Borough | Church View Road | |
| 15:00 | Pilkington | 0-5 | Winsford United | Arcoframe Stadium | |
| 15:00 | Prescot Cables | 2-0 | Lower Breck | URETEK Stadium | |
| 15:00 | Queens Park U23 | P-P | Nelson | Hampden Park | |
| 13:00 | Runcorn Town | 0-4 | Coton Green | Viridor Community Stadium | |
| 15:00 | Sandbach United | 2-1 | Ashton Athletic | Sandbach Community Football Centre | |
| 15:00 | Squires Gate | 3-0 | Steeton | The Brian Addison Stadium | |
| 12:15 | St Michaels DH | v | Alsager Town | Ormiston Chadwick Academy | |
| 15:00 | Stockport Town | 3-2 | Silsden | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton | 1-2 | 1874 Northwich | Step Places Stadium | |
| 15:00 | Witton Albion | 2-0 | Northwich Victoria | Wincham Park | |
| Vijay Anthwaol Memorial Shield | |||||
| 15:00 | Wolstanton United | 2-2 | Ellesmere Rangers | The Stant | |
| 12:00 | Wythenshawe Amateurs | 1-2 | Prestwich Heys | Selco Builders Warehouse Community Stadium | |
| 15:00 | Wythenshawe Town | 1-1 | Maine Road | Ericstan Park | |
| Monday 25th July 2022 | |||||
| 19:30 | Prestwich Heys | v | New Mills | Adie Moran Park | |
| Tuesday 26th July 2022 | |||||
| 19:30 | Abbey Hulton United | v | Abbey Hulton UtdRes | Drayton Beaumont Park | |
| 19:30 | Ashton Athletic | v | Bamber Bridge | Brocstedes Park | |
| 19:30 | Chadderton | v | Mossley | The Falcon Fire Stadium | |
| 19:30 | Chadderton Cott | v | Cheadle Heath Nomads | Failsworth School | |
| 19:45 | Charnock Richard | v | Preston North End XI | Mossie Park | |
| 19:00 | Cleator Moor Celtic | v | Windscale | McGrath Park | |
| 18:45 | Eagle Sports | v | FC St Helens | Eagle Sports & Social Club | |
| 19:45 | Glossop North End | v | Abbey Hey | Surrey Street | |
| John Harvey Trophy | |||||
| 19:00 | Holker Old Boys | v | Walney Island | The Handmark Engineering Stadium | |
| 19:30 | MSB Woolton | v | AFC Liverpool | Simpsons Ground | |
| 19:00 | Rochdale Sacred Heart | v | Runcorn Town | Belfield Mill Lane | |
| 19:00 | Stockport Georgians | v | Runcorn Linnets | Cromley Road | |
| 19:45 | Trafford | v | West Didsbury & Chorlton | Shawe View | |
| 19:45 | Winsford United | v | Oldham Athletic | Barton Stadium | |
| Wednesday 27th July 2022 | |||||
| 19:45 | Ashville | v | South Liverpool | Villa Park | |
| 19:30 | Garswood United | v | Pilkington | CleanHire Community Stadium | |
| Friday 17th June 2022 | |
| Burnley United 1-5 Padiham Barden Sports Ground | |
| Saturday 18th June 2022 | |
| FC United of Wrexham 0-7 Ashville Bronwen Green | |
| Wednesday 22nd June 2022 | |
| Darwen FC 0-3 Longridge Town WEC Group Anchor Ground | |
| Friday 24th June 2022 | |
| Garstang 0-2 Longridge Town The Riverside | |
| Saturday 25th June 2022 | |
| Bolton United 1-2 Prestwich Heys Barlow Park | |
| Macclesfield U18 0-1 Atherton LR The Leasing.com Stadium | |
| Pilkington 4-3 Sandbach United The Arcoframe Stadium | |
| Tuesday 28th June 2022 | |
| Darwen FC 0-6 Blackburn Rovers XI WEC Group Anchor Ground | |
| Euxton Villa 1-4 Chorley Jim Fowler Memorial Ground | |
| Longridge Town 0-9 Bolton Wanderers The Recycling Lives Ground | |
| Friday 1st July 2022 | |
| Bacup Borough 3-1 Avro Brian Boys West View Stadium | |
| Eccleshall 0-2 Hanley Town Pershall Park | |
| Euxton Villa 3-0 Bootle Jim Fowler Memorial Ground | |
| Lower Breck 4-1 Sefton Athletic Anfield Sports Community Centre | |
| Saturday 2nd July 2022 | |
| Abbey Hulton United 2-1 Congleton Town Drayton Beaumont Park | |
| Barnton 3-1 City of Liverpool Townfield | |
| Blackpool Wren Rovers 0-0 Prestwich Heys Bruce Park | |
| Burscough Richmond 0-5 Pilkington JMO Sports Park | |
| Cefn Druids 0-1 AFC Liverpool The Rock | |
| Chadderton 3-5 Padiham The Falcon Fire Stadium | |
| Cheadle Heath Nomads 2-1 Cheadle Heath Nomads Res The Heath | |
| Cheadle Town 2-1 Winsford United Park Road Stadium | |
| CMB 2-1 Ashton Athletic New Tempest Road | |
| Egerton 1-2 Atherton LR Mereheath Lane | |
| FC Isle of Man 2-1 Nostell Miners Welfare The Bowl | |
| FC St Helens 3-2 Newton Sutton Leisure 3G | |
| Hindsford 4-5 Sandbach United Squires Lane | |
| Holker Old Boys 1-3 Barrow The Handmark Engineering Stadium | |
| Ilkley Town 1-0 Thackley MPM Stadium | |
| Llandudno 3-4 Northwich Victoria Maesdu Park | |
| Longridge Town 1-3 Macclesfield The Recycling Lives Ground | |
| Lostock St Gerrards 1-2 Darwen FC Wateringpool Lane | |
| Maine Road 3-3 Denton Town Wright Robinson College | |
| New Mills 0-3 Curzon Ashton Church Lane | |
| Rocester 2-3 Stoke City U18 Hillsfield | |
| Runcorn Sports 2-2 Ashton Town Runcorn Sports Club | |
| South Liverpool 8-0 Capenhurst Villa North Field | |
| Squires Gate 0-2 Nelson The Brian Addison Stadium | |
| Stafford Town 2-0 Stafford Rangers Evans Park | |
| Steeton P-P Barnoldswick Town Marley Stadium | |
| Stockport Georgians 1-5 Wythenshawe Town Seashells 3G pitch | |
| Stockport Town 0-4 Bury AFC Stockport Sports Village | |
| Thornton Cleveleys 1-5 Kendal Town Myerscough College | |
| Vauxhall Motors 5-2 Widnes The vanEupen Arena | |
| Warstone Wanderers 1-2 Brocton Penkridge Recreation Centre | |
| Wythenshawe Amateurs 3-2 Daisy Hill Manchester Health Academy | |
| Monday 4th July 2022 | |
| Stockport Town 2-1 Winsford United Stockport Sports Village | |
| Tuesday 5th July 2022 | |
| Atherton Collieries 3-1 Bury AFC The Kensite Stadium | |
| Bacup Borough 2-4 Chorley Brian Boys West View Stadium | |
| Brocton 1-1 AFC Wulfrunians Silkmore Lane Sports Ground | |
| Cheadle Heath Nomads 1-1 Wythenshawe Town The Heath | |
| Coppull United 1-2 Northwich Victoria Blainscough Park | |
| Eccleshall 0-1 Newcastle Town Pershall Park | |
| Ellesmere Rangers 3-2 Cefn Druids Beech Grove Stadium | |
| Ilkley Town 1-5 Knareborough Town MPM Stadium | |
| Longridge Town P-P FC United of Manchester The Recycling Lives Ground | |
| Sandbach United 0-1 Atherton LR Sandbach Community Football Centre | |
| Silsden 0-1 Nelson The Cobbydale Construction Stadium | |
| Tintwistle Athletic 0-5 Cheadle Town West Drive Football Centre | |
| Vauxhall Motors 3-2 Ashton Town The vanEupen Arena | |
| Whitehaven Amateurs 0-5 Cleator Moor Celtic County Ground | |
| Wednesday 6th July 2022 | |
| Alsager Town 1-4 Macclesfield XI Woodpark Stadium | |
| Avro 1-1 Radcliffe Vestacare Stadium | |
| CMB 1-5 Euxton Villa New Tempest Road | |
| Croston Sports 0-5 Barnoldswick Town Croston Sports Club | |
| Garstang 3-1 Squires Gate The Riverside | |
| Kendal Town 0-9 Carlisle United J Robs Ground Maintenance Stadium | |
| Rocester 4-1 Port Vale u18 Hillsfield | |
| Thornton Cleveleys 1-2 Padiham Poolfoot Farm | |
| Wellington Amateurs 0-3 Stafford Town School Grove | |
| Friday 8th July 2022 | |
| Abbey Hulton United 0-0 Kidsgrove Athletic Drayton Beaumont Park | |
| Buckley Town 0-2 AFC Liverpool Globe Way | |
| FC St Helens 1-2 Wythenshawe Amateurs Windleshaw Sports Ground | |
| Fulwood Amateurs 4-3 AFC Blackpool | |
| Holker Old Boys 5-2 Vickerstown The Handmark Engineering Stadium | |
| Saturday 9th July 2022 | |
| Alsager Town 0-2 Congleton Town Woodpark Stadium | |
| Avro 3-0 Daisy Hill Vestacare Stadium | |
| Barnton 1-1 Witton Albion Townfield | |
| Brocton 2-2 Walsall Wood Silkmore Lane Sports Ground | |
| Cammell Laird 1907 0-2 City of Liverpool Prabhu Ventures Ltd Arena | |
| Carlisle City 3-1 Cleator Moor Celtic The Don Marks Carpets Stadium | |
| Caton United 1-8 Kendal Town Caton Sports Field | |
| Charnock Richard 1-5 Chorley Mossie Park | |
| Cheadle Heath Nomads 5-2 Ashton Athletic The Heath | |
| Cheadle Town 0-2 Stephen Ireland XI Park Road Stadium | |
| Eccleshall 2-2 Altrincham XI Pershall Park | |
| Egerton 2-5 Irlam Mereheath Lane | |
| Euxton Villa 4-1 Stockport Georgians Jim Fowler Memorial Ground | |
| FC Isle of Man 0-1 Widnes The Bowl | |
| Garstang 6-0 Poulton The Riverside | |
| Guiseley 3-1 Bury AFC Nethermoor Park | |
| Helsby 3-5 Runcorn Town Helsby Community Sports Centre | |
| Hyde United 2-3 Stockport Town Ewen Fields | |
| Longridge Town 1-3 Blackpool The Recycling Lives Ground | |
| Lower Breck 2-0 Chadderton Anfield Sports Community Centre | |
| Maghull 1-1 South Liverpool Old Hall Field | |
| MSB Woolton 2-1 Ashton Town Simpsons Ground | |
| Nelson 1-2 Hurst Green Little Wembley | |
| Newton Aycliffe 1-1 Abbey Hey Moore Lane Sports Club Ground | |
| Northwich Victoria 1-1 Matlock Town Wincham Park | |
| Otley Town 0-6 Ilkley Town The Old Showground | |
| Pilkington 3-3 Conwy Borough The Arcoframe Stadium | |
| Prestwich Heys 3-0 Ramsbottom United Adie Moran Park | |
| Rossendale 3-5 Barnoldswick Town Marl Pits Sports Centre | |
| Squires Gate 1-1 Colne The Brian Addison Stadium | |
| Stafford Town 0-1 Lye Town Evans Park | |
| Steeton 3-1 Heyside Marley Stadium | |
| Trafford 3-0 Maine Road Shawe View | |
| Vauxhall Motors 2-3 Marine The vanEupen Arena | |
| West Didsbury & Chorlton 2-0 Altrincham XI Step Places Stadium | |
| Winnington Avenue 94 3-0 Atherton LR Park Stadium | |
| Winsford United 2-0 New Mills Barton Stadium | |
| Wythenshawe Town 2-2 Altrincham XI Ericstan Park | |
| Sunday 10th July 2022 | |
| Padiham 1-0 Clitheroe Ruby Civil Arena | |
| Monday 11th July 2022 | |
| Prestwich Heys 6-2 Eagley Adie Moran Park | |
| Stockport Town 1-0 West Didsbury & Chorlton Stockport Sports Village | |
| Tuesday 12th July 2022 | |
| Abbey Hey 2-3 Radcliffe The Abbey Stadium | |
| Abbey Hulton United 2-1 Hanley Town Drayton Beaumont Park | |
| Alsager Town 1-2 Market Drayton Town Woodpark Stadium | |
| Ball Haye Green 0-4 Eccleshall Pointon Park | |
| Barnoldswick Town 2-5 Clitheroe Silentnight Stadium | |
| Barnton 6-1 Middlewich Town Townfield | |
| Brocton 3-1 Stone Old Alleynians Silkmore Lane Sports Ground | |
| Burnley Belvedere 1-2 Chadderton Belvedere Ground | |
| Charnock Richard 8-1 Winstanley Warriors Mossie Park | |
| Cheadle Heath Nomads 0-0 Northwich Victoria The Heath | |
| CMB 2-1 Daisy Hill New Tempest Road | |
| Congleton Town 2-1 Leek Town The Cleric Stadium | |
| Ellesmere Port Town 2-1 Atherton LR Whitby Sports Club | |
| Ellesmere Rangers 1-3 Shawbury United Beech Grove Stadium | |
| Euxton Villa 0-0 Chester XI Jim Fowler Memorial Ground | |
| FC United of Manchester 4-2 Bury AFC Broadhurst Park | |
| Foley Meir 2-2 Newcastle Town McIntosh Arena | |
| Padiham 2-1 Burnley U18 Ruby Civil Arena | |
| Runcorn Town 2-2 Squires Gate Viridor Community Stadium | |
| Slyne with Hest 2-3 Kendal Town Bottomdale Road | |
| South Liverpool 2-4 Lower Breck Jericho Lane | |
| Stockport Georgians 5-2 Burscough Cromley Road | |
| Vauxhall Motors 1-3 Colwyn Bay The vanEupen Arena | |
| Winsford United 2-2 1874 Northwich Barton Stadium | |
| Wednesday 13th July 2022 | |
| Darwen FC 3-4 Rossendale WEC Group Anchor Ground | |
| Garstang 4-2 Lostock St Gerards The Riverside | |
| Prestwich Heys 3-2 Walshaw Sports St Annes Field (Tottington United) | |
| Thursday 14th July 2022 | |
| AFC Liverpool 2-2 Cammell Laird 1907 St John Bosco 3G | |
| Ilkley Town 2-1 Horbury Town MPM Stadium | |
| Longridge Town 3-2 Preston North End XI The Recycling Lives Ground | |
| Nelson 1-1 Ramsbottom United Little Wembley | |
| Friday 15th July 2022 | |
| Congleton Town 1-0 Kidsgrove Athletic The Cleric Stadium | |
| Daisy Hill 4-1 Ashton United New Sirs | |
| Saturday 16th July 2022 | |
| Abbey Hey 0-6 Hyde United The Abbey Stadium | |
| AFC Blackpool 3-3 Northwich Victoria Mechanics Ground | |
| AFC Knowsley P-P Ashville | |
| Allscott Heath 2-1 Foley Meir Allscott Sports & Social Club | |
| Ashington 0-1 Charnock Richard Woodhorn Lane | |
| Ashton Town 1-1 Ashton Athletic Hebs Group Stadium | |
| Avro 2-2 Mossley Vestacare Stadium | |
| Bacup Borough 0-0 Winsford United Brian Boys West View Stadium | |
| Barnoldswick Town 1-1 Colne Silentnight Stadium | |
| Brereton Social 0-4 Rocester Red Lion Ground | |
| Brocton 1-0 Heath Hayes Silkmore Lane Sports Ground | |
| Cammell Laird 1907 0-1 Warrington Rylands Prabhu Ventures Ltd Arena | |
| Cheadle Heath Nomads 0-5 1874 Northwich The Heath | |
| Cheadle Town 2-1 Denton Town Park Road Stadium | |
| Conwy Borough 0-3 West Didsbury & Chorlton Y Morfa Stadium | |
| Darwen FC P-P Euxton Villa WEC Group Anchor Ground | |
| FC Isle of Man 1-5 Altrincham The Bowl | |
| FC Isle of Man 0-4 Shifnal Town The Bowl | |
| FC St Helens 9-0 Sefton Athletic Windleshaw Sports Ground | |
| Haddington Athletic 3-3 Garstang Pennypit Park | |
| Kendal Town 1-2 Carlisle City J Robs Ground Maintenance Stadium | |
| Leek CSOB 2-3 Sandbach United Pointon Park | |
| Llangollen Town 0-11 Barnton Runcorn Sports Club | |
| Longridge Town 1-6 Bamber Bridge The Recycling Lives Ground | |
| Lostock Gralam 2-0 Alsager Town Park Stadium | |
| Lower Breck 6-1 Bootle Anfield Sports Community Centre | |
| Maine Road 3-2 Pilkington Wright Robinson College | |
| Nelson 1-0 AFC Liverpool Little Wembley | |
| New Mills 2-4 Trafford Church Lane | |
| Ramsbottom United 1-0 Bury AFC Riverside Ground | |
| Runcorn Town 1-1 Abbey Hulton United Viridor Community Stadium | |
| South Liverpool 1-0 Litherland Remyca Jericho Lane | |
| Squires Gate 2-4 Radcliffe The Brian Addison Stadium | |
| St Helens Town 1-3 Atherton LR Arcoframe Stadium | |
| Stafford Town 0-2 Chadderton Evans Park | |
| Steeton 1-4 Silsden Marley Stadium | |
| Stockport Georgians 0-0 Royton Town Cromley Road | |
| Stockport Town 2-2 Runcorn Linnets Stockport Sports Village | |
| Vauxhall Motors 1-2 Ruthin Town The vanEupen Arena | |
| Whitchurch Alport P-P Prestwich Heys KMJ Mortgages Stadium | |
| Wolstanton United 2-1 Eccleshall Bradwell Community Centre | |
| Wyre Villa P-P Holker Old Boys | |
| Wythenshawe Amateurs 0-4 Irlam Manchester Enterprise Academy | |
| Wythenshawe Town 1-3 Warrington Town Ericstan Park | |
| Tuesday 19th July 2022 | |
| Audley P-P Eccleshall Town Fields | |
| Cammell Laird 1907 0-4 Tranmere Rovers XI Prabhu Ventures Ltd Arena | |
| Daisy Hill 3-2 Wythenshawe Town New Sirs | |
| Egerton P-P Wythenshawe Amateurs Mereheath Lane | |
| Garstang 3-0 Lancaster City The Riverside | |
| Ilkley Town P-P Eccleshill United MPM Stadium | |
| Kendal Town 2-0 Fleetwood Town XI J Robs Ground Maintenance Stadium | |
| Northwich Victoria P-P City of Liverpool Wincham Park | |
| South Liverpool P-P AFC Liverpool Jericho Lane | |
| Squires Gate 0-0 Wren Rovers The Brian Addison Stadium | |
| Tottington United P-P Atherton LR St Annes Field | |
| Trafford 2-0 Bury AFC Shawe View | |
| Vauxhall Motors P-P Witton Albion The vanEupen Arena | |
| Wednesday 20th July 2022 | |
| Alsager Town 2-0 Port Vale XI Woodpark Stadium | |
| Ashton Athletic 0-4 FC United of Manchester Brocstedes Park | |
| Barnton 0-2 1874 Northwich Townfield | |
| Campion 6-0 Steeton The Players Cars Stadium | |
| Ellesmere Rangers 0-3 Airbus UK Broughton Beech Grove Stadium | |
| Euxton Villa 1-0 Runcorn Linnets Jim Fowler Memorial Ground | |
| Runcorn Town P-P Skelmersdale United Viridor Community Stadium | |
| Sandbach United 1-0 West Didsbury & Chorlton Sandbach Community Football Centre | |
| Stapenhill 3-2 Rocester Edge Hill Football Ground | |
| Whaley Bridge 3-0 Stockport Georgians Park Road | |
| Winsford United 3-0 Nantwich Town Barton Stadium | |
| Thursday 21st July 2022 | |
| Abbey Hey 0-7 Chadderton The Abbey Stadium | |
| Abbey Hulton United 3-2 Newcastle Town Drayton Beaumont Park | |
| AFC Bridgnorth 0-1 Stafford Town Crown Meadow | |
| Brocton 2-1 Wolverhampton Casuals Silkmore Lane Sports Ground | |
| Cheadle Town 2-1 Hyde United Park Road Stadium | |
| Irlam 0-1 Mossley The RG3 Digital Stadium | |
| New Mills 1-1 Ramsbottom United Church Lane | |
| Silsden 7-2 Ilkley Town The Cobbydale Construction Stadium | |
| Friday 22nd July 2022 | |
| Eccleshall 2-5 Congleton Town Pershall Park | |
| FC St Helens 4-1 Rainhill Town Windleshaw Sports Ground | |
| Johnstone Burgh 1-1 Nelson Keanie Park | |
| Saturday 23rd July 2022 | |
| Abbey Hulton United 5-0 Rochdale Academy Drayton Beaumont Park | |
| Barnoldswick Town 2-2 Fleetwood Town XI Silentnight Stadium | |
| Barnton 0-0 Altrincham XI Townfield | |
| Barrow Town 4-3 Stafford Town Riverside Park | |
| Brigg Town P-P Avro The EC Surfacing Stadium | |
| Brocton 1-2 Lye Town Silkmore Lane Sports Ground | |
| Cammell Laird 1907 0-3 Vauxhall Motors Prabhu Ventures Ltd Arena | |
| Carlisle City 3-4 Nelson The Don Marks Carpets Stadium | |
| Chadderton 3-3 Trafford The Falcon Fire Stadium | |
| Cheadle Heath Nomads 2-1 Bury AFC The Heath | |
| Cleator Moor Celtic 3-3 Crook Town McGrath Park | |
| Coppull United v Atherton LR Blainscough Park | |
| Daisy Hill 1-3 Radcliffe New Sirs | |
| Darwen FC 2-0 Turton WEC Group Anchor Ground | |
| FC Isle of Man 2-0 Guernsey The Bowl | |
| Garstang 7-2 Cheadle Town The Riverside | |
| Golcar United 3-3 Abbey Hey Skye Direct Stadium | |
| Haslingden St Mary’s 2-2 Euxton Villa St. Marys Ground | |
| Holker Old Boys 1-3 Longridge Town The Handmark Engineering Stadium | |
| Kendal Town 5-2 Workington J Robs Ground Maintenance Stadium | |
| Marine 3-2 AFC Liverpool The Marine Travel Arena | |
| Marshalls A-A Ashville IM Marsh Campus | |
| Nostell Miners Welfare 1-3 Ilkley Town Crofton Community Centre | |
| Padiham 0-2 Colne Ruby Civil Arena | |
| Penistone Church 4-1 Bacup Borough Church View Road | |
| Pilkington 0-5 Winsford United Arcoframe Stadium | |
| Prescot Cables 2-0 Lower Breck URETEK Stadium | |
| Queens Park U23 P-P Nelson Hampden Park | |
| Runcorn Town 0-4 Coton Green Viridor Community Stadium | |
| Sandbach United 2-1 Ashton Athletic Sandbach Community Football Centre | |
| Squires Gate 3-0 Steeton The Brian Addison Stadium | |
| St Michaels DH v Alsager Town Ormiston Chadwick Academy | |
| Stockport Town 3-2 Silsden Stockport Sports Village | |
| West Didsbury & Chorlton 1-2 1874 Northwich Step Places Stadium | |
| Witton Albion 2-0 Northwich Victoria Wincham Park | |
| Wolstanton United 2-2 Ellesmere Rangers The Stant | |
| Wythenshawe Amateurs 1-2 Prestwich Heys Selco Builders Warehouse Community Stadium | |
| Wythenshawe Town 1-1 Maine Road Ericstan Park | |
| Monday 25th July 2022 | |
| Prestwich Heys v New Mills Adie Moran Park | |
| Tuesday 26th July 2022 | |
| Abbey Hulton United v Abbey Hulton Utd Reserves Drayton Beaumont Park | |
| Ashton Athletic v Bamber Bridge Brocstedes Park | |
| Chadderton v Mossley The Falcon Fire Stadium | |
| Chadderton Cott v Cheadle Heath Nomads Failsworth School | |
| Charnock Richard v Preston North End XI Mossie Park | |
| Cleator Moor Celtic v Windscale McGrath Park | |
| Eagle Sports v FC St Helens Eagle Sports & Social Club | |
| Glossop North End v Abbey Hey Surrey Street | |
| Holker Old Boys v Walney Island The Handmark Engineering Stadium | |
| MSB Woolton v AFC Liverpool Simpsons Ground | |
| Rochdale Sacred Heart v Runcorn Town Belfield Mill Lane | |
| Stockport Georgians v Runcorn Linnets Cromley Road | |
| Trafford v West Didsbury & Chorlton Shawe View | |
| Winsford United v Oldham Athletic Barton Stadium | |
| Wednesday 27th July 2022 | |
| Ashville v South Liverpool Villa Park | |
| Garswood United v Pilkington CleanHire Community Stadium | |
