| Tuesday 4th October 2022 | The Emirates F.A Cup 3rd Qual Rnd Rply | ||
| 19:45 |  AFC Fylde v Congleton Town  | Mill Farm | |
| Tuesday 4th October 2022 | Premier Division | ||
| 19:45 |  Burscough v FC Isle of Man  | The Community Ground | |
| 19:45 |  West Didsbury & Chorlton v Lower Breck  | Step Places Stadium | |
| 19:45 |  Wythenshawe Town P-P Congleton Town | Ericstan Park | |
| Postponed due to Congleton in FA Cup replay | |||
| Tuesday 4th October 2022 | First Division North | ||
| 19:45 |  FC St Helens v South Liverpool  | Windleshaw Sports Ground | |
| Tuesday 4th October 2022 | First Division South | ||
| 19:45 |  Foley Meir v Stafford Town  | McIntosh Arena | |
| Tuesday 4th October 2022 | Lancashire Challenge Trophy 1st Rnd | ||
| 19:45 |  Charnock Richard v Prestwich Heys  | Mossie Park | |
| Tuesday 4th October 2022 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 |  Eccleshall v Sporting Khalsa  | Pershall Park | |
| Tuesday 4th October 2022 | West Riding County Cup 1st Rnd | ||
| 19:45 |  Selby Town v Barnoldswick Town  | Richard Street | |
| Tuesday 4th October 2022 | Westmoreland Senior Cup 1st Rnd | ||
| 19:45 |  Kendal Town P-P Keswick  | Parkside Road Stadium | |
| Postponed due to waterlogged pitch | |||
| Wednesday 5th October 2022 | The Emirates F.A Cup 3rd Qual Rnd Rply | ||
| 19:45 |  Bury AFC v Clitheroe  | Neuven Stadium | |
| Wednesday 5th October 2022 | Lancashire Challenge Trophy 1st Rnd | ||
| 20:00 |  Euxton Villa v Wythenshawe Amateurs  | Jim Fowler Memorial Ground | |
| Friday 7th October 2022 | Premier Division | ||
| 20:00 |  AFC Liverpool v Barnoldswick Town | The Marine Travel Arena | |
| Saturday 8th October 2022 | The Edward Case Cup 2nd Round North | ||
| 15:00 |  AFC Blackpool v FC St Helens | Mechanics Ground | |
| 15:00 |  Ashton Town v Runcorn Town  | Hebs Group Stadium | |
| 15:00 |  Bacup Borough v Cleator Moor Celtic  | Brian Boys West View Stadium | |
| 15:00 |  Chadderton v Garstang  | The Falcon Fire Stadium | |
| 15:00 |  Daisy Hill v Pilkington  | New Sirs | |
| 15:00 |  Ilkley Town v Euxton Villa | MPM Stadium | |
| 15:00 |  Nelson v Steeton  | Little Wembley | |
| 15:00 | South Liverpool v Holker Old Boys  | Jericho Lane | |
| Saturday 8th October 2022 | The Edward Case Cup 2nd Round South | ||
| 15:00 |  Cammell Laird 1907 v Abbey Hey  | Prabhu Ventures Ltd Arena | |
| 15:00 | Eccleshall v Cheadle Heath Nomads  | Pershall Park | |
| 15:00 |  Ellesmere Rangers v Stafford Town | Beech Grove Stadium | |
| 15:00 | Foley Meir v Abbey Hulton United  | McIntosh Arena | |
| 15:00 |  Maine Road v Barnton  | Brantingham Road | |
| 15:00 |  Sandbach United v Cheadle Town  | Sandbach Community Football Centre | |
| 15:00 |  Stockport Town v Brocton  | Stockport Sports Village | |
| 15:00 | Wythenshawe Amateurs v New Mills  | Selco Builders Warehouse Community Stadium | |
| Saturday 8th October 2022 | Premier Division | ||
| 15:00 |  Ashton Athletic v Prestwich Heys | Brocstedes Park | |
| 15:00 | Bury AFC v Avro  | Neuven Stadium | |
| 15:00 | Charnock Richard v Longridge Town  | Mossie Park | |
| 15:00 | Kendal Town v Vauxhall Motors  | Parkside Road Stadium | |
| 15:00 |  Litherland REMYCA v Irlam  | Litherland Sports Park | |
| 15:00 | Lower Breck v Northwich Victoria  | Anfield Sports Community Centre | |
| 15:00 | West Didsbury & Chorlton v Congleton Town | Step Places Stadium | |
| 15:00 |  Winsford United v Burscough | Barton Stadium | |
| 15:00 | Wythenshawe Town v Squires Gate  | Ericstan Park | |
| 18:00 | FC Isle of Man v Padiham  | The Bowl | |
| Saturday 8th October 2022 | First Division South | ||
| 15:00 |  Stockport Georgians v Rocester  | Cromley Road | |
| Tuesday 11th October 2022 | Premier Division | ||
| 19:45 | Congleton Town v Burscough | The Cleric Stadium | |
| 19:45 | Kendal Town v Ashton Athletic | Parkside Road Stadium | |
| 19:45 | Prestwich Heys v Padiham | Adie Moran Park | |
| 19:45 | West Didsbury & Chorlton v FC Isle of Man | Step Places Stadium | |
| Tuesday 11th October 2022 | First Division South | ||
| 19:45 | Stockport Georgians v Cheadle Heath Nomads | Cromley Road | |
| Tuesday 11th October 2022 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Sandbach United v Altrincham  | Sandbach Community Football Centre | |
| Tuesday 11th October 2022 | Derbyshire Senior Cup 1st Rnd | ||
| 19:45 | New Mills v Clay Cross Town  | Church Lane | |
| Tuesday 11th October 2022 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | Wythenshawe Town v Bury AFC | Ericstan Park | |
| Tuesday 11th October 2022 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 | Brocton v Foley Meir | Silkmore Lane Sports Ground | |
| Tuesday 11th October 2022 | West Riding County Cup 1st Rnd | ||
| 19:45 | Steeton v Silsden  | Marley Stadium | |
| Tuesday 11th October 2022 | Cumberland Senior Cup 1st Rnd | ||
| 19:45 | Cleator Moor Celtic v Carlisle United  | McGrath Park | |
| Tuesday 11th October 2022 | Walsall Senior Cup 1st Rnd | ||
| 19:45 | Rocester v Walsall  | Hillsfield | |
| Wednesday 12th October 2022 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | Avro v Chadderton | Vestacare Stadium | |
| Saturday 15th October 2022 | Premier Division | ||
| 15:00 | Wythenshawe Town v Northwich Victoria | Ericstan Park | |
| Sunday 16th October 2022 | The Macron Cup 1st Rnd | ||
| 14:00 | AFC Liverpool v FC Isle of Man | The Marine Travel Arena | |
| 15:00 | Bury AFC v Padiham | Neuven Stadium | |
| Monday 17th October 2022 | First Division South | ||
| 19:45 | Stockport Town v Eccleshall | Stockport Sports Village | |
| Tuesday 18th October 2022 | Premier Division | ||
| 19:45 | Bury AFC v Barnoldswick Town | Neuven Stadium | |
| 19:45 | Charnock Richard v Northwich Victoria | Mossie Park | |
| 19:45 | Wythenshawe Town v Congleton Town | Ericstan Park | |
| Tuesday 18th October 2022 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 |  Witton Albion v Ashville  | Wincham Park | |
| Tuesday 18th October 2022 | Manchester Premier Cup 1st Rnd | ||
| 19:45 |  Glossop North End v West Didsbury & Chorlton | Surrey Street | |
| Thursday 20th October 2022 | Premier Division | ||
| 20:00 | Lower Breck v AFC Liverpool | Anfield Sports Community Centre | |
| Saturday 22nd October 2022 | The Isuzu FA Vase 1st Rnd | ||
| 15:00 | Barnoldswick Town v Selby Town | Silentnight Stadium | |
| 15:00 |  Barton Town v Cheadle Town | The Easy Buy Stadium | |
| 15:00 |  Billingham Town v FC Isle of Man | Bedford Terrace | |
| 15:00 | Brocton v Wolverhampton Casuals  | Silkmore Lane Sports Ground | |
| 15:00 |  Campion v Bacup Borough | The Players Cars Stadium | |
| 15:00 |  Darwen FC v Litherland REMYCA | WEC Group Anchor Ground | |
| 15:00 | FC St Helens v Penistone Church  | Windleshaw Sports Ground | |
| 15:00 | Holker Old Boys v Whickham  | The Handmark Engineering Stadium | |
| 15:00 | Kendal Town v Longridge Town | Parkside Road Stadium | |
| 15:00 |  Newent Town v Eccleshall | Wildsmith Meadow | |
| 15:00 | Sandbach United v Kimberley Miners Welfare  | Sandbach Community Football Centre | |
| 15:00 | Squires Gate v Cammell Laird 1907 | The Brian Addison Stadium | |
| 15:00 |  Thornaby v Pilkington | Teesdale Park | |
| 15:00 | West Didsbury & Chorlton v Golcar United  | Step Places Stadium | |
| 15:00 |  Winterton Rangers v Prestwich Heys | West Street | |
| Saturday 22nd October 2022 | Premier Division | ||
| 15:00 | Avro v Ashton Athletic | Vestacare Stadium | |
| 15:00 | Burscough v Prestwich Heys | The Community Ground | |
| 15:00 | Charnock Richard v Vauxhall Motors | Mossie Park | |
| 15:00 | Congleton Town v Lower Breck | The Cleric Stadium | |
| 15:00 | Padiham v Wythenshawe Town | Ruby Civil Arena | |
| 15:00 | Winsford United v AFC Liverpool | Barton Stadium | |
| Saturday 22nd October 2022 | First Division North | ||
| 15:00 | Ashton Town v Chadderton | Hebs Group Stadium | |
| 15:00 | Daisy Hill v AFC Blackpool | New Sirs | |
| 15:00 | Ilkley Town v Atherton LR  | MPM Stadium | |
| 15:00 | Nelson v South Liverpool | Little Wembley | |
| 15:00 | Steeton v Runcorn Town | Marley Stadium | |
| Saturday 22nd October 2022 | First Division South | ||
| 15:00 | Abbey Hey v Stockport Georgians | The Abbey Stadium | |
| 15:00 | Barnton v Wythenshawe Amateurs | Townfield | |
| 15:00 | Cheadle Heath Nomads v Maine Road | ProSeal Stadium | |
| 15:00 | Foley Meir v New Mills | McIntosh Arena | |
| 15:00 | Rocester v Ellesmere Rangers | Hillsfield | |
| 15:00 | Stafford Town v Alsager Town  | Evans Park | |
| 15:00 | Stockport Town v Abbey Hulton United | Stockport Sports Village | |
| Sunday 23rd October 2022 | The Isuzu FA Vase 1st Rnd | ||
| 14:00 | Bury AFC v Bishop Auckland  | Neuven Stadium | |
| Monday 24th October 2022 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | Maine Road v Irlam | Brantingham Road | |
| Tuesday 25th October 2022 | Premier Division | ||
| 19:45 | Congleton Town v Prestwich Heys | The Cleric Stadium | |
| 19:45 | Kendal Town v Winsford United | Parkside Road Stadium | |
| 19:45 | West Didsbury & Chorlton v Bury AFC | Step Places Stadium | |
| 19:45 | Wythenshawe Town v FC Isle of Man | Ericstan Park | |
| Tuesday 25th October 2022 | First Division South | ||
| 19:45 | Abbey Hey v Cammell Laird 1907 | The Abbey Stadium | |
| Tuesday 25th October 2022 | West Riding County Cup 1st Rnd | ||
| 19:45 | Ilkley Town v Harrogate Railway Athletic  | MPM Stadium | |
| Tuesday 4th October 2022 The Emirates F.A Cup 3rd Qualifying Round Replay |
| AFC Fylde v Congleton Town (19:45) |
| Tuesday 4th October 2022 Premier Division |
|
| Burscough v FC Isle of Man (19:45) | |
| West Didsbury & Chorlton v Lower Breck (19:45) | |
| Wythenshawe Town P-P Congleton Town (19:45) | |
| Postponed due to Congleton in FA Cup replay | |
| Tuesday 4th October 2022 First Division North |
| FC St Helens v South Liverpool (19:45) |
| Tuesday 4th October 2022 First Division South |
| Foley Meir v Stafford Town (19:45) |
| Tuesday 4th October 2022 Lancashire Challenge Trophy 1st Round |
| Charnock Richard v Prestwich Heys (19:45) |
| Tuesday 4th October 2022 Staffordshire Senior Cup 1st Round |
| Eccleshall v Sporting Khalsa (19:45) |
| Tuesday 4th October 2022 West Riding County Cup 1st Round |
| Selby Town v Barnoldswick Town (19:45) |
| Tuesday 4th October 2022 Westmoreland Senior Cup 1st Round |
|
| Kendal Town P-P Keswick (19:45) | |
| Postponed due to waterlogged pitch | |
| Wednesday 5th October 2022 The Emirates F.A Cup 3rd Qualifying Round Replay |
| Bury AFC v Clitheroe (19:45) |
| Wednesday 5th October 2022 Lancashire Challenge Trophy 1st Round |
| Euxton Villa v Wythenshawe Amateurs (20:00) |
| Friday 7th October 2022 Premier Division |
| AFC Liverpool v Barnoldswick Town (20:00) |
| Saturday 8th October 2022 The Edward Case Cup 2nd Round North |
| AFC Blackpool v FC St Helens (15:00) |
| Ashton Town v Runcorn Town (15:00) |
| Bacup Borough v Cleator Moor Celtic (15:00) |
| Chadderton v Garstang (15:00) |
| Daisy Hill v Pilkington (15:00) |
| Ilkley Town v Euxton Villa (15:00) |
| Nelson v Steeton (15:00) |
| South Liverpool v Holker Old Boys (15:00) |
| Saturday 8th October 2022 The Edward Case Cup 2nd Round South |
| Cammell Laird 1907 v Abbey Hey (15:00) |
| Eccleshall v Cheadle Heath Nomads (15:00) |
| Ellesmere Rangers v Stafford Town (15:00) |
| Foley Meir v Abbey Hulton United (15:00) |
| Maine Road v Barnton (15:00) |
| Sandbach United v Cheadle Town (15:00) |
| Stockport Town v Brocton (15:00) |
| Wythenshawe Amateurs v New Mills (15:00) |
| Saturday 8th October 2022 Premier Division |
| Ashton Athletic v Prestwich Heys (15:00) |
| Bury AFC v Avro (15:00) |
| Charnock Richard v Longridge Town (15:00) |
| Kendal Town v Vauxhall Motors (15:00) |
| Litherland REMYCA v Irlam (15:00) |
| Lower Breck v Northwich Victoria (15:00) |
| West Didsbury & Chorlton v Congleton Town (15:00) |
| Winsford United v Burscough (15:00) |
| Wythenshawe Town v Squires Gate (15:00) |
| FC Isle of Man v Padiham (18:00) |
| Saturday 8th October 2022 First Division South |
| Stockport Georgians v Rocester (15:00) |
| Tuesday 11th October 2022 Premier Division |
| Congleton Town v Burscough (19:45) |
| Kendal Town v Ashton Athletic (19:45) |
| Prestwich Heys v Padiham (19:45) |
| West Didsbury & Chorlton v FC Isle of Man (19:45) |
| Tuesday 11th October 2022 First Division South |
| Stockport Georgians v Cheadle Heath Nomads (19:45) |
| Tuesday 11th October 2022 Cheshire Senior Cup 1st Round |
| Sandbach United v Altrincham (19:45) |
| Tuesday 11th October 2022 Derbyshire Senior Cup 1st Round |
| New Mills v Clay Cross Town (19:45) |
| Tuesday 11th October 2022 Manchester Premier Cup 1st Round |
| Wythenshawe Town v Bury AFC (19:45) |
| Tuesday 11th October 2022 Staffordshire Senior Cup 1st Round |
| Brocton v Foley Meir (19:45) |
| Tuesday 11th October 2022 West Riding County Cup 1st Round |
| Steeton v Silsden (19:45) |
| Tuesday 11th October 2022 Cumberland Senior Cup 1st Round |
| Cleator Moor Celtic v Carlisle United (19:45) |
| Tuesday 11th October 2022 Walsall Senior Cup 1st Round |
| Rocester v Walsall (19:45) |
| Wednesday 12th October 2022 Manchester Premier Cup 1st Round |
| Avro v Chadderton (19:45) |
| Saturday 15th October 2022 Premier Division |
| Wythenshawe Town v Northwich Victoria (15:00) |
| Sunday 16th October 2022 The Macron Cup 1st Round |
| AFC Liverpool v FC Isle of Man (14:00) |
| Bury AFC v Padiham (15:00) |
| Monday 17th October 2022 First Division South |
| Stockport Town v Eccleshall (19:45) |
| Tuesday 18th October 2022 Premier Division |
| Bury AFC v Barnoldswick Town (19:45) |
| Charnock Richard v Northwich Victoria (19:45) |
| Wythenshawe Town v Congleton Town (19:45) |
| Tuesday 18th October 2022 Cheshire Senior Cup 1st Round |
| Witton Albion v Ashville (19:45) |
| Tuesday 18th October 2022 Manchester Premier Cup 1st Round |
| Glossop North End v West Didsbury & Chorlton (19:45) |
| Thursday 20th October 2022 Premier Division |
| Lower Breck v AFC Liverpool (20:00) |
| Saturday 22nd October 2022 The Isuzu FA Vase 1st Round |
| Barnoldswick Town v Selby Town (15:00) |
| Barton Town v Cheadle Town (15:00) |
| Billingham Town v FC Isle of Man (15:00) |
| Brocton v Wolverhampton Casuals (15:00) |
| Campion v Bacup Borough (15:00) |
| Darwen FC v Litherland REMYCA (15:00) |
| FC St Helens v Penistone Church (15:00) |
| Holker Old Boys v Whickham (15:00) |
| Kendal Town v Longridge Town (15:00) |
| Newent Town v Eccleshall (15:00) |
| Sandbach United v Kimberley Miners Welfare (15:00) |
| Squires Gate v Cammell Laird 1907 (15:00) |
| Thornaby v Pilkington (15:00) |
| West Didsbury & Chorlton v Golcar United (15:00) |
| Winterton Rangers v Prestwich Heys (15:00) |
| Saturday 22nd October 2022 Premier Division |
| Avro v Ashton Athletic (15:00) |
| Burscough v Prestwich Heys (15:00) |
| Charnock Richard v Vauxhall Motors (15:00) |
| Congleton Town v Lower Breck (15:00) |
| Padiham v Wythenshawe Town (15:00) |
| Winsford United v AFC Liverpool (15:00) |
| Saturday 22nd October 2022 First Division North |
| Ashton Town v Chadderton (15:00) |
| Daisy Hill v AFC Blackpool (15:00) |
| Ilkley Town v Atherton LR (15:00) |
| Nelson v South Liverpool (15:00) |
| Steeton v Runcorn Town (15:00) |
| Saturday 22nd October 2022 First Division South |
| Abbey Hey v Stockport Georgians (15:00) |
| Barnton v Wythenshawe Amateurs (15:00) |
| Cheadle Heath Nomads v Maine Road (15:00) |
| Foley Meir v New Mills (15:00) |
| Rocester v Ellesmere Rangers (15:00) |
| Stafford Town v Alsager Town (15:00) |
| Stockport Town v Abbey Hulton United (15:00) |
| Sunday 23rd October 2022 The Isuzu FA Vase 1st Round |
| Bury AFC v Bishop Auckland (14:00) |
| Monday 24th October 2022 Manchester Premier Cup 1st Round |
| Maine Road v Irlam (19:45) |
| Tuesday 25th October 2022 Premier Division |
| Congleton Town v Prestwich Heys (19:45) |
| Kendal Town v Winsford United (19:45) |
| West Didsbury & Chorlton v Bury AFC (19:45) |
| Wythenshawe Town v FC Isle of Man (19:45) |
| Tuesday 25th October 2022 First Division South |
| Abbey Hey v Cammell Laird 1907 (19:45) |
| Tuesday 25th October 2022 West Riding County Cup 1st Round |
| Ilkley Town v Harrogate Railway Athletic (19:45) |
