| Tuesday 11th February 2025 | Premier Division | ||
| 19:45 |  Barnoldswick Town v FC St Helens  | Silentnight Stadium | |
| 19:45 |  Charnock Richard v Abbey Hey  | Mossie Park | |
| 19:45 |  Colne v Lower Breck  | Haffners Stadium | |
| 19:45 |  Longridge Town v Padiham  | Longridge Town FC | |
| 19:45 |  Ramsbottom United v Chadderton  | Harry Williams Riverside Stadium | |
| Tuesday 11th February 2025 | First Division South | ||
| 19:45 |  Winsford United v Abbey Hulton United  | Barton Stadium | |
| Friday 14th February 2025 | The Macron Cup QF | ||
| 19:45 |  Barnton v Lower Breck | The Creative Hut Stadium | |
| Saturday 15th February 2025 | The Macron Cup QF | ||
| 15:00 | Charnock Richard v Maghull  | Mossie Park | |
| 15:00 | Ramsbottom United v Stafford Town  | Harry Williams Riverside Stadium | |
| 16:00 | Chadderton v AFC Blackpool  | Vestacare Stadium | |
| Played at Avro | |||
| Saturday 15th February 2025 | Premier Division | ||
| 15:00 |  Bury v West Didsbury & Chorlton  | Gigg Lane | |
| 15:00 | Colne v Stockport Town  | Haffners Stadium | |
| 15:00 | FC St Helens v Cheadle Town  | SMS PRO SOCCER PARK | |
| 15:00 |  Irlam v AFC Liverpool  | The Silver St Stadium | |
| 15:00 |  Litherland REMYCA v Glossop North End  | Litherland Sports Park | |
| 15:00 | Padiham v Longridge Town | Ruby Civil Arena | |
| 15:00 |  Prestwich Heys v Pilkington  | Adie Moran Park | |
| 15:00 |  South Liverpool v Abbey Hey | Jericho Lane | |
| 15:00 |  Squires Gate v Burscough  | The Brian Addison Stadium | |
| 18:00 |  FC Isle of Man v Barnoldswick Town | The Bowl | |
| Saturday 15th February 2025 | First Division North | ||
| 14:00 |  Ashton Athletic v Nelson  | Brocstedes Park | |
| 15:00 |  Atherton LR v Euxton Villa  | Crilly Park | |
| 15:00 |  Bacup Borough v Ashton Town  | Brian Boys West View Stadium | |
| 15:00 |  Holker Old Boys v Steeton  | The Handmark Engineering Stadium | |
| 15:00 |  Maine Road v Daisy Hill  | Brantingham Road | |
| 15:00 |  Route One Rovers v Droylsden  | Marley Stadium | |
| 15:00 |  Skelmersdale United v Garstang  | The Community Ground | |
| 15:00 |  Thornton Cleveleys v Darwen FC  | Gamble Road | |
| Saturday 15th February 2025 | First Division South | ||
| 15:00 |  Ashville v Allscott Heath  | Ray Parker Stadium | |
| 15:00 |  Cheadle Heath Nomads v Stockport Georgians  | Ideal Building Systems Stadium | |
| 15:00 |  Eccleshall v New Mills  | Stoke Signage Stadium | |
| 15:00 |  Runcorn Town v Market Drayton Town  | Viridor Community Stadium | |
| 15:00 |  Sandbach United v Foley Meir  | Sandbach Community Football Centre | |
| 15:00 |  Shawbury United v Abbey Hulton United | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Winsford United v Cammell Laird 1907  | Barton Stadium | |
| Tuesday 18th February 2025 | Premier Division | ||
| 19:45 | Charnock Richard v Colne | Mossie Park | |
| 19:45 | FC St Helens v Longridge Town | SMS PRO SOCCER PARK | |
| 19:45 | Padiham v Barnoldswick Town | Ruby Civil Arena | |
| Thursday 20th February 2025 | Premier Division | ||
| 20:00 | Lower Breck v Chadderton | Anfield Sports Community Centre | |
| Friday 21st February 2025 | First Division South | ||
| 20:00 | Winsford United v Shawbury United | Barton Stadium | |
| Saturday 22nd February 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Squires Gate | The Abbey Stadium | |
| 15:00 | AFC Liverpool v Prestwich Heys | The Marine Travel Arena | |
| 15:00 | Barnoldswick Town v Stockport Town | Silentnight Stadium | |
| 15:00 | Cheadle Town v Glossop North End | The Ground Up Solutions Stadium | |
| 15:00 | FC St Helens v Padiham | SMS PRO SOCCER PARK | |
| 15:00 | Irlam v Burscough | The Silver St Stadium | |
| 15:00 | Litherland REMYCA v Charnock Richard | Litherland Sports Park | |
| 15:00 | South Liverpool v Bury | Jericho Lane | |
| 15:00 | West Didsbury & Chorlton v Pilkington | Step Places Stadium | |
| 16:00 | Chadderton v Longridge Town | Vestacare Stadium | |
| Played at Avro | |||
| 18:00 | FC Isle of Man v Colne | The Bowl | |
| Saturday 22nd February 2025 | First Division North | ||
| 14:00 | Ashton Athletic v Holker Old Boys | Brocstedes Park | |
| 15:00 | AFC Blackpool v Ashton Town | Mechanics Ground | |
| 15:00 | Atherton LR v Nelson | Crilly Park | |
| 15:00 | Bacup Borough v Droylsden | Brian Boys West View Stadium | |
| 15:00 | Route One Rovers v Euxton Villa | Marley Stadium | |
| Saturday 22nd February 2025 | First Division South | ||
| 15:00 | Abbey Hulton United v Allscott Heath | Drayton Beaumont Park | |
| 15:00 | Barnton v Ashville | The Creative Hut Stadium | |
| 15:00 | Cammell Laird 1907 v Wolverhampton Sporting Community  | KRCT LTD STADIUM | |
| 15:00 | Cheadle Heath Nomads v Sandbach United | Ideal Building Systems Stadium | |
| 15:00 | Market Drayton Town v Stockport Georgians | Greenfields Sports Ground | |
| 15:00 | Stafford Town v Foley Meir | Evans Park | |
| Tuesday 25th February 2025 | Premier Division | ||
| 19:45 | Longridge Town v Stockport Town | Longridge Town FC | |
| 19:45 | Padiham v Colne | Ruby Civil Arena | |
| Wednesday 26th February 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v West Didsbury & Chorlton | Litherland Sports Park | |
| Friday 28th February 2025 | Premier Division | ||
| 19:45 | Chadderton v Irlam | Vestacare Stadium | |
| Played at Avro | |||
| 19:45 | Ramsbottom United v FC St Helens | Harry Williams Riverside Stadium | |
| Friday 28th February 2025 | First Division North | ||
| 19:45 | Daisy Hill v Atherton LR | The Plumb Factory Stadium | |
| 19:45 | Euxton Villa v Skelmersdale United | Jim Fowler Memorial Ground | |
| Saturday 1st March 2025 | Premier Division | ||
| 13:30 | Burscough v FC Isle of Man | The Community Ground | |
| 13:45 | Stockport Town v Cheadle Town | Stockport Sports Village | |
| 15:00 | Bury v Litherland REMYCA | Gigg Lane | |
| 15:00 | Colne v Charnock Richard | Haffners Stadium | |
| 15:00 | Longridge Town v Lower Breck | Longridge Town FC | |
| 15:00 | Padiham v AFC Liverpool | Ruby Civil Arena | |
| 15:00 | Pilkington v Barnoldswick Town | PSD Stadium | |
| 15:00 | Squires Gate v South Liverpool | The Brian Addison Stadium | |
| 19:30 | Glossop North End v West Didsbury & Chorlton | The Asgard Engineering Stadium | |
| Saturday 1st March 2025 | First Division North | ||
| 15:00 | Ashton Town v Route One Rovers | The Bartons Group Stadium | |
| 15:00 | Garstang v Thornton Cleveleys | The Riverside | |
| 15:00 | Maghull v Holker Old Boys | DT Hughes Community Stadium | |
| 15:00 | Maine Road v Ashton Athletic | Brantingham Road | |
| 15:00 | Steeton v Nelson | Marley Stadium | |
| Saturday 1st March 2025 | First Division South | ||
| 11:00 | Stockport Georgians v Sandbach United | Cromley Road | |
| 15:00 | Abbey Hulton United v Cammell Laird 1907 | Drayton Beaumont Park | |
| 15:00 | Allscott Heath v Alsager Town  | The Giant Stadium | |
| 15:00 | Market Drayton Town v Ashville | Greenfields Sports Ground | |
| 15:00 | Shawbury United v Barnton | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stafford Town v Runcorn Town | Evans Park | |
| 15:00 | Winsford United v Eccleshall | Barton Stadium | |
| 16:45 | New Mills v Cheadle Heath Nomads | Church Lane | |
| Sunday 2nd March 2025 | Premier Division | ||
| 11:30 | Abbey Hey v Prestwich Heys | The Abbey Stadium | |
| Sunday 2nd March 2025 | First Division North | ||
| 14:30 | Droylsden v Darwen FC | The Butchers Arms | |
| Tuesday 4th March 2025 | Premier Division | ||
| 19:45 | Ramsbottom United v Padiham | Harry Williams Riverside Stadium | |
| Tuesday 11th February 2025 Premier Division |
| Barnoldswick Town v FC St Helens (19:45) |
| Charnock Richard v Abbey Hey (19:45) |
| Colne v Lower Breck (19:45) |
| Longridge Town v Padiham (19:45) |
| Ramsbottom United v Chadderton (19:45) |
| Tuesday 11th February 2025 First Division South |
| Winsford United v Abbey Hulton United (19:45) |
| Friday 14th February 2025 The Macron Cup Quarter Finals |
| Barnton v Lower Breck (19:45) |
| Saturday 15th February 2025 The Macron Cup Quarter Finals |
|
| Charnock Richard v Maghull (15:00) | |
| Ramsbottom United v Stafford Town (15:00) | |
| Chadderton v AFC Blackpool (16:00) | |
| Played at Avro | |
| Saturday 15th February 2025 Premier Division |
| Bury v West Didsbury & Chorlton (15:00) |
| Colne v Stockport Town (15:00) |
| FC St Helens v Cheadle Town (15:00) |
| Irlam v AFC Liverpool (15:00) |
| Litherland REMYCA v Glossop North End (15:00) |
| Padiham v Longridge Town (15:00) |
| Prestwich Heys v Pilkington (15:00) |
| South Liverpool v Abbey Hey (15:00) |
| Squires Gate v Burscough (15:00) |
| FC Isle of Man v Barnoldswick Town (18:00) |
| Saturday 15th February 2025 First Division North |
| Ashton Athletic v Nelson (14:00) |
| Atherton LR v Euxton Villa (15:00) |
| Bacup Borough v Ashton Town (15:00) |
| Holker Old Boys v Steeton (15:00) |
| Maine Road v Daisy Hill (15:00) |
| Route One Rovers v Droylsden (15:00) |
| Skelmersdale United v Garstang (15:00) |
| Thornton Cleveleys v Darwen FC (15:00) |
| Saturday 15th February 2025 First Division South |
| Ashville v Allscott Heath (15:00) |
| Cheadle Heath Nomads v Stockport Georgians (15:00) |
| Eccleshall v New Mills (15:00) |
| Runcorn Town v Market Drayton Town (15:00) |
| Sandbach United v Foley Meir (15:00) |
| Shawbury United v Abbey Hulton United (15:00) |
| Winsford United v Cammell Laird 1907 (15:00) |
| Tuesday 18th February 2025 Premier Division |
| Charnock Richard v Colne (19:45) |
| FC St Helens v Longridge Town (19:45) |
| Padiham v Barnoldswick Town (19:45) |
| Thursday 20th February 2025 Premier Division |
| Lower Breck v Chadderton (20:00) |
| Friday 21st February 2025 First Division South |
| Winsford United v Shawbury United (20:00) |
| Saturday 22nd February 2025 Premier Division |
|
| Abbey Hey v Squires Gate (15:00) | |
| AFC Liverpool v Prestwich Heys (15:00) | |
| Barnoldswick Town v Stockport Town (15:00) | |
| Cheadle Town v Glossop North End (15:00) | |
| FC St Helens v Padiham (15:00) | |
| Irlam v Burscough (15:00) | |
| Litherland REMYCA v Charnock Richard (15:00) | |
| South Liverpool v Bury (15:00) | |
| West Didsbury & Chorlton v Pilkington (15:00) | |
| Chadderton v Longridge Town (16:00) | |
| Played at Avro | |
| FC Isle of Man v Colne (18:00) | |
| Saturday 22nd February 2025 First Division North |
| Ashton Athletic v Holker Old Boys (14:00) |
| AFC Blackpool v Ashton Town (15:00) |
| Atherton LR v Nelson (15:00) |
| Bacup Borough v Droylsden (15:00) |
| Route One Rovers v Euxton Villa (15:00) |
| Saturday 22nd February 2025 First Division South |
| Abbey Hulton United v Allscott Heath (15:00) |
| Barnton v Ashville (15:00) |
| Cammell Laird 1907 v Wolverhampton Sporting Community (15:00) |
| Cheadle Heath Nomads v Sandbach United (15:00) |
| Market Drayton Town v Stockport Georgians (15:00) |
| Stafford Town v Foley Meir (15:00) |
| Tuesday 25th February 2025 Premier Division |
| Longridge Town v Stockport Town (19:45) |
| Padiham v Colne (19:45) |
| Wednesday 26th February 2025 Premier Division |
| Litherland REMYCA v West Didsbury & Chorlton (19:45) |
| Friday 28th February 2025 Premier Division |
|
| Chadderton v Irlam (19:45) | |
| Played at Avro | |
| Ramsbottom United v FC St Helens (19:45) | |
| Friday 28th February 2025 First Division North |
| Daisy Hill v Atherton LR (19:45) |
| Euxton Villa v Skelmersdale United (19:45) |
| Saturday 1st March 2025 Premier Division |
| Burscough v FC Isle of Man (13:30) |
| Stockport Town v Cheadle Town (13:45) |
| Bury v Litherland REMYCA (15:00) |
| Colne v Charnock Richard (15:00) |
| Longridge Town v Lower Breck (15:00) |
| Padiham v AFC Liverpool (15:00) |
| Pilkington v Barnoldswick Town (15:00) |
| Squires Gate v South Liverpool (15:00) |
| Glossop North End v West Didsbury & Chorlton (19:30) |
| Saturday 1st March 2025 First Division North |
| Ashton Town v Route One Rovers (15:00) |
| Garstang v Thornton Cleveleys (15:00) |
| Maghull v Holker Old Boys (15:00) |
| Maine Road v Ashton Athletic (15:00) |
| Steeton v Nelson (15:00) |
| Saturday 1st March 2025 First Division South |
| Stockport Georgians v Sandbach United (11:00) |
| Abbey Hulton United v Cammell Laird 1907 (15:00) |
| Allscott Heath v Alsager Town (15:00) |
| Market Drayton Town v Ashville (15:00) |
| Shawbury United v Barnton (15:00) |
| Stafford Town v Runcorn Town (15:00) |
| Winsford United v Eccleshall (15:00) |
| New Mills v Cheadle Heath Nomads (16:45) |
| Sunday 2nd March 2025 Premier Division |
| Abbey Hey v Prestwich Heys (11:30) |
| Sunday 2nd March 2025 First Division North |
| Droylsden v Darwen FC (14:30) |
| Tuesday 4th March 2025 Premier Division |
| Ramsbottom United v Padiham (19:45) |
