| Wednesday 27th October 2021 | First Division North | ||
| 19:45 |  Garstang v Cleator Moor Celtic  |
The Riverside | |
| 19:45 |  Pilkington v Bury AFC  |
The Arcoframe Stadium | |
| Wednesday 27th October 2021 | First Division South | ||
| 19:45 |  Cheadle Town v FC Isle of Man  |
Park Road Stadium | |
| Wednesday 27th October 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 |  Northwich Victoria v Tranmere Rovers  |
Wincham Park | |
| Friday 29th October 2021 | Premier Division | ||
| 20:00 |  AFC Liverpool v Wythenshawe Town  |
The Marine Travel Arena | |
| 20:00 |  Lower Breck v Macclesfield  |
Anfield Sports Community Centre | |
| Saturday 30th October 2021 | Premier Division | ||
| 15:00 |  Ashton Athletic v Irlam  |
Brocstedes Park | |
| 15:00 |  Avro v Runcorn Town  |
Vestacare Stadium | |
| 15:00 |  Barnoldswick Town v Skelmersdale United  |
Silentnight Stadium | |
| 15:00 |  Congleton Town v Winsford United  |
Cheshire Silk 106.9 Stadium | |
| 15:00 |  Litherland REMYCA v Padiham  |
Litherland Sports Park | |
| 15:00 |  Prestwich Heys v Longridge Town  |
Adie Moran Park | |
| 15:00 |  Squires Gate v Northwich Victoria |
The Brian Addison Stadium | |
| 15:00 |  Vauxhall Motors v Burscough  |
The vanEupen Arena | |
| Saturday 30th October 2021 | First Division North | ||
| 15:00 |  AFC Darwen v AFC Blackpool  |
WEC Group Anchor Ground | |
| 15:00 |  Ashton Town v Campion  |
Profiles Park | |
| 15:00 | Bury AFC P-P Chadderton  |
Neuven Stadium | |
| Postponed due to Radcliffe in FA Trophy | |||
| 15:00 | Cleator Moor Celtic v Atherton LR  |
Inglenorth Park | |
| 15:00 |  Daisy Hill v Ilkley Town  |
New Sirs | |
| 15:00 |  Golcar United v St Helens Town  |
Skye Direct Stadium | |
| 15:00 |  Nelson v Bacup Borough  |
Little Wembley | |
| 15:00 | Pilkington v Garstang |
The Arcoframe Stadium | |
| 15:00 |  Steeton v Holker Old Boys  |
Marley Stadium | |
| Saturday 30th October 2021 | First Division South | ||
| 15:00 |  Alsager Town v Eccleshall  |
Woodpark Stadium | |
| 15:00 |  Barnton v St Martins  |
Townfield | |
| 15:00 |  Cammell Laird 1907 v Stockport Town  |
Prabhu Ventures Ltd Arena | |
| 15:00 | Cheadle Town v Sandbach United  |
Park Road Stadium | |
| 15:00 |  Ellesmere Rangers v Abbey Hulton United  |
Beech Grove Stadium | |
| 15:00 |  Maine Road v Cheadle Heath Nomads  |
Brantingham Road | |
| 15:00 |  Rocester v New Mills  |
Hillsfield | |
| 15:00 |  Stafford Town v Abbey Hey  |
Evans Park | |
| 15:00 |  West Didsbury & Chorlton v Wythenshawe Amateurs  |
Step Places Stadium | |
| 18:30 | FC Isle of Man v Brocton  |
The Bowl | |
| Tuesday 2nd November 2021 | Premier Division | ||
| 19:45 | Ashton Athletic v Longridge Town |
Brocstedes Park | |
| 19:45 | Burscough v Northwich Victoria |
The Community Ground | |
| Tuesday 2nd November 2021 | First Division North | ||
| 19:45 | Bury AFC v Chadderton |
Neuven Stadium | |
| 20:00 | Ilkley Town v Atherton LR |
MPM Stadium | |
| Tuesday 2nd November 2021 | First Division South | ||
| 20:00 | St Martins v FC Isle of Man |
Park Hall Stadium | |
| Tuesday 2nd November 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Macclesfield v Cheadle Heath Nomads |
The Leasing.com Stadium | |
| Tuesday 2nd November 2021 | West Riding County Cup 1st Rnd | ||
| 19:45 | Golcar United v Steeton |
Skye Direct Stadium | |
| Wednesday 3rd November 2021 | First Division North | ||
| 19:45 | AFC Darwen v Cleator Moor Celtic |
WEC Group Anchor Ground | |
| Saturday 6th November 2021 | Premier Division | ||
| 15:00 | AFC Liverpool v Barnoldswick Town |
The Marine Travel Arena | |
| 15:00 | Burscough v Prestwich Heys |
The Community Ground | |
| 15:00 | Congleton Town v Lower Breck |
Cheshire Silk 106.9 Stadium | |
| 15:00 | Irlam v Charnock Richard  |
The RG3 Digital Stadium | |
| 15:00 | Longridge Town v Litherland REMYCA |
The Mike Riding Ground | |
| 15:00 | Macclesfield v Runcorn Town |
The Leasing.com Stadium | |
| 15:00 | Northwich Victoria v Ashton Athletic |
Wincham Park | |
| 15:00 | Padiham v Skelmersdale United |
Ruby Civil Arena | |
| 15:00 | Winsford United v Squires Gate |
Barton Stadium | |
| 15:00 | Wythenshawe Town v Avro |
Ericstan Park | |
| Saturday 6th November 2021 | First Division North | ||
| 15:00 | AFC Blackpool v Golcar United |
Mechanics Ground | |
| 15:00 | Bacup Borough v Atherton LR |
Brian Boys West View Stadium | |
| 15:00 | Campion v Pilkington |
The Players Cars Stadium | |
| 15:00 | Chadderton v Cleator Moor Celtic |
The Falcon Fire Stadium | |
| 15:00 | Daisy Hill v Steeton |
New Sirs | |
| 15:00 | Holker Old Boys v Bury AFC |
The Handmark Engineering Stadium | |
| 15:00 | Nelson v Ashton Town |
Little Wembley | |
| 15:00 |  South Liverpool v Garstang |
Jericho Lane | |
| 15:00 | St Helens Town v AFC Darwen |
Arcoframe Stadium | |
| Saturday 6th November 2021 | First Division South | ||
| 15:00 | Abbey Hey v Rocester |
The Abbey Stadium | |
| 15:00 | Alsager Town v Abbey Hulton United |
Woodpark Stadium | |
| 15:00 | Brocton v Maine Road |
Silkmore Lane Sports Ground | |
| 15:00 | Cammell Laird 1907 v New Mills |
Prabhu Ventures Ltd Arena | |
| 15:00 | Cheadle Town v Ellesmere Rangers |
Park Road Stadium | |
| 15:00 | Sandbach United v Barnton |
Sandbach Community Football Centre | |
| 15:00 | Stockport Town v St Martins |
Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Eccleshall |
Step Places Stadium | |
| 15:00 | Wythenshawe Amateurs v Cheadle Heath Nomads |
Hollyhedge Park | |
| 18:30 | FC Isle of Man v Stafford Town |
The Bowl | |
| Tuesday 9th November 2021 | Premier Division | ||
| 19:45 | AFC Liverpool v Macclesfield |
The Marine Travel Arena | |
| 19:45 | Burscough v Avro |
The Community Ground | |
| 19:45 | Congleton Town v Skelmersdale United |
Cheshire Silk 106.9 Stadium | |
| 19:45 | Prestwich Heys v Runcorn Town |
Adie Moran Park | |
| 19:45 | Wythenshawe Town v Charnock Richard |
Ericstan Park | |
| Tuesday 9th November 2021 | First Division North | ||
| 19:45 | Ashton Town v Daisy Hill |
Profiles Park | |
| 19:45 | Bury AFC v AFC Blackpool |
Neuven Stadium | |
| 19:45 | Cleator Moor Celtic v Pilkington |
Inglenorth Park | |
| 19:45 | Golcar United v AFC Darwen |
Skye Direct Stadium | |
| 20:00 | Bacup Borough v South Liverpool |
Brian Boys West View Stadium | |
| Tuesday 9th November 2021 | First Division South | ||
| 19:45 | Alsager Town v New Mills |
Woodpark Stadium | |
| 19:45 | Cammell Laird 1907 v Abbey Hey |
Prabhu Ventures Ltd Arena | |
| 19:45 | Ellesmere Rangers v Rocester |
Beech Grove Stadium | |
| 19:45 | Sandbach United v FC Isle of Man |
Sandbach Community Football Centre | |
| 19:45 | West Didsbury & Chorlton v Cheadle Town |
Step Places Stadium | |
| Wednesday 10th November 2021 | Premier Division | ||
| 19:45 | Barnoldswick Town v Northwich Victoria |
Silentnight Stadium | |
| 19:45 | Litherland REMYCA v Winsford United |
Litherland Sports Park | |
| Wednesday 10th November 2021 | First Division North | ||
| 20:00 | Garstang v Chadderton |
The Riverside | |
| Wednesday 10th November 2021 | First Division South | ||
| 19:45 | Barnton v Maine Road |
Townfield | |
| Wednesday 10th November 2021 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 | Abbey Hulton United v Stoke City  |
Drayton Beaumont Park | |
| Thursday 11th November 2021 | Premier Division | ||
| 20:00 | Lower Breck v Padiham |
Anfield Sports Community Centre | |
| Thursday 11th November 2021 | First Division North | ||
| 19:45 | St Helens Town v Holker Old Boys |
Arcoframe Stadium | |
| Saturday 13th November 2021 | Premier Division | ||
| 15:00 | Barnoldswick Town v Ashton Athletic |
Silentnight Stadium | |
| 15:00 | Burscough v Charnock Richard |
The Community Ground | |
| 15:00 | Irlam v AFC Liverpool |
The RG3 Digital Stadium | |
| 15:00 | Lower Breck v Northwich Victoria |
Anfield Sports Community Centre | |
| 15:00 | Runcorn Town v Padiham |
Viridor Community Stadium | |
| 15:00 | Skelmersdale United v Macclesfield |
One Call Stadium at JMO Sports Park | |
| 15:00 | Squires Gate v Wythenshawe Town |
The Brian Addison Stadium | |
| 15:00 | Vauxhall Motors v Avro |
The vanEupen Arena | |
| 15:00 | Winsford United v Longridge Town |
Barton Stadium | |
| Saturday 13th November 2021 | First Division North | ||
| 15:00 | AFC Blackpool v Daisy Hill |
Mechanics Ground | |
| 15:00 | Atherton LR v Holker Old Boys |
Crilly Park | |
| 15:00 | Bury AFC v South Liverpool |
Neuven Stadium | |
| 15:00 | Campion v AFC Darwen |
The Players Cars Stadium | |
| 15:00 | Chadderton v Nelson |
The Falcon Fire Stadium | |
| 15:00 | Cleator Moor Celtic v Ashton Town |
Inglenorth Park | |
| 15:00 | Garstang v Bacup Borough |
The Riverside | |
| 15:00 | Golcar United v Ilkley Town |
Skye Direct Stadium | |
| 15:00 | Pilkington v Steeton |
The Arcoframe Stadium | |
| Saturday 13th November 2021 | First Division South | ||
| 15:00 | Barnton v Cammell Laird 1907 |
Townfield | |
| 15:00 | Brocton v Alsager Town |
Silkmore Lane Sports Ground | |
| 15:00 | Cheadle Heath Nomads v Stafford Town |
ProSeal Stadium | |
| 15:00 | Eccleshall v Cheadle Town |
Pershall Park | |
| 15:00 | Ellesmere Rangers v Abbey Hey |
Beech Grove Stadium | |
| 15:00 | New Mills v Sandbach United |
Church Lane | |
| 15:00 | St Martins v West Didsbury & Chorlton |
Park Hall Stadium | |
| 15:00 | Stockport Town v Maine Road |
Stockport Sports Village | |
| 15:00 | Wythenshawe Amateurs v Abbey Hulton United |
Hollyhedge Park | |
| 18:30 | FC Isle of Man v Rocester |
The Bowl | |
| Tuesday 16th November 2021 | Premier Division | ||
| 19:45 | Vauxhall Motors v Charnock Richard |
The vanEupen Arena | |
| Tuesday 16th November 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:15 |  Crewe Alexandra v Sandbach United |
Gresty Road | |
| Tuesday 16th November 2021 | Mid Cheshire Senior Cup SF | ||
| 19:45 | Winsford United v Northwich Victoria |
Barton Stadium | |
| Wednesday 27th October 2021 First Division North |
| Garstang v Cleator Moor (19:45) |
| Pilkington v Bury AFC (19:45) |
| Wednesday 27th October 2021 First Division South |
| Cheadle Town v FC Isle of Man (19:45) |
| Wednesday 27th October 2021 Cheshire Senior Cup 1st Rnd |
| Northwich Vics v Tranmere Rovers (19:45) |
| Friday 29th October 2021 Premier Division |
| AFC Liverpool v Wythenshawe Town (20:00) |
| Lower Breck v Macclesfield (20:00) |
| Saturday 30th October 2021 Premier Division |
| Ashton Athletic v Irlam (15:00) |
| Avro v Runcorn Town (15:00) |
| Barnoldswick Town v Skelmersdale Utd (15:00) |
| Congleton Town v Winsford United (15:00) |
| Litherland REMY v Padiham (15:00) |
| Prestwich Heys v Longridge Town (15:00) |
| Squires Gate v Northwich Vics (15:00) |
| Vauxhall Mtrs v Burscough (15:00) |
| Saturday 30th October 2021 First Division North |
|
| AFC Darwen v AFC Blackpool (15:00) | |
| Ashton Town v Campion (15:00) | |
| Bury AFC P-P Chadderton (15:00) | |
| Postponed due to Radcliffe in FA Trophy | |
| Cleator Moor v Atherton LR (15:00) | |
| Daisy Hill v Ilkley Town (15:00) | |
| Golcar United v St Helens Town (15:00) | |
| Nelson v Bacup Borough (15:00) | |
| Pilkington v Garstang (15:00) | |
| Steeton v Holker OB (15:00) | |
| Saturday 30th October 2021 First Division South |
| Alsager Town v Eccleshall (15:00) |
| Barnton v St Martins (15:00) |
| Cammell Laird v Stockport Town (15:00) |
| Cheadle Town v Sandbach United (15:00) |
| Ellesmere Rngrs v Abbey Hulton Utd (15:00) |
| Maine Road v Cheadle Heath (15:00) |
| Rocester v New Mills (15:00) |
| Stafford Town v Abbey Hey (15:00) |
| West Didsbury v Wythenshawe Am (15:00) |
| FC Isle of Man v Brocton (18:30) |
| Tuesday 2nd November 2021 Premier Division |
| Ashton Athletic v Longridge Town (19:45) |
| Burscough v Northwich Vics (19:45) |
| Tuesday 2nd November 2021 First Division North |
| Bury AFC v Chadderton (19:45) |
| Ilkley Town v Atherton LR (20:00) |
| Tuesday 2nd November 2021 First Division South |
| St Martins v FC Isle of Man (20:00) |
| Tuesday 2nd November 2021 Cheshire Senior Cup 1st Rnd |
| Macclesfield v Cheadle Heath (19:45) |
| Tuesday 2nd November 2021 West Riding County Cup 1st Rnd |
| Golcar United v Steeton (19:45) |
| Wednesday 3rd November 2021 First Division North |
| AFC Darwen v Cleator Moor (19:45) |
| Saturday 6th November 2021 Premier Division |
| AFC Liverpool v Barnoldswick Town (15:00) |
| Burscough v Prestwich Heys (15:00) |
| Congleton Town v Lower Breck (15:00) |
| Irlam v Charnock Richard (15:00) |
| Longridge Town v Litherland REMY (15:00) |
| Macclesfield v Runcorn Town (15:00) |
| Northwich Vics v Ashton Athletic (15:00) |
| Padiham v Skelmersdale Utd (15:00) |
| Winsford United v Squires Gate (15:00) |
| Wythenshawe Town v Avro (15:00) |
| Saturday 6th November 2021 First Division North |
| AFC Blackpool v Golcar United (15:00) |
| Bacup Borough v Atherton LR (15:00) |
| Campion v Pilkington (15:00) |
| Chadderton v Cleator Moor (15:00) |
| Daisy Hill v Steeton (15:00) |
| Holker OB v Bury AFC (15:00) |
| Nelson v Ashton Town (15:00) |
| South Liverpool v Garstang (15:00) |
| St Helens Town v AFC Darwen (15:00) |
| Saturday 6th November 2021 First Division South |
| Abbey Hey v Rocester (15:00) |
| Alsager Town v Abbey Hulton Utd (15:00) |
| Brocton v Maine Road (15:00) |
| Cammell Laird v New Mills (15:00) |
| Cheadle Town v Ellesmere Rngrs (15:00) |
| Sandbach United v Barnton (15:00) |
| Stockport Town v St Martins (15:00) |
| West Didsbury v Eccleshall (15:00) |
| Wythenshawe Am v Cheadle Heath (15:00) |
| FC Isle of Man v Stafford Town (18:30) |
| Tuesday 9th November 2021 Premier Division |
| AFC Liverpool v Macclesfield (19:45) |
| Burscough v Avro (19:45) |
| Congleton Town v Skelmersdale Utd (19:45) |
| Prestwich Heys v Runcorn Town (19:45) |
| Wythenshawe Town v Charnock Richard (19:45) |
| Tuesday 9th November 2021 First Division North |
| Ashton Town v Daisy Hill (19:45) |
| Bury AFC v AFC Blackpool (19:45) |
| Cleator Moor v Pilkington (19:45) |
| Golcar United v AFC Darwen (19:45) |
| Bacup Borough v South Liverpool (20:00) |
| Tuesday 9th November 2021 First Division South |
| Alsager Town v New Mills (19:45) |
| Cammell Laird v Abbey Hey (19:45) |
| Ellesmere Rngrs v Rocester (19:45) |
| Sandbach United v FC Isle of Man (19:45) |
| West Didsbury v Cheadle Town (19:45) |
| Wednesday 10th November 2021 Premier Division |
| Barnoldswick Town v Northwich Vics (19:45) |
| Litherland REMY v Winsford United (19:45) |
| Wednesday 10th November 2021 First Division North |
| Garstang v Chadderton (20:00) |
| Wednesday 10th November 2021 First Division South |
| Barnton v Maine Road (19:45) |
| Wednesday 10th November 2021 Staffordshire Senior Cup 1st Rnd |
| Abbey Hulton Utd v Stoke City (19:45) |
| Thursday 11th November 2021 Premier Division |
| Lower Breck v Padiham (20:00) |
| Thursday 11th November 2021 First Division North |
| St Helens Town v Holker OB (19:45) |
| Saturday 13th November 2021 Premier Division |
| Barnoldswick Town v Ashton Athletic (15:00) |
| Burscough v Charnock Richard (15:00) |
| Irlam v AFC Liverpool (15:00) |
| Lower Breck v Northwich Vics (15:00) |
| Runcorn Town v Padiham (15:00) |
| Skelmersdale Utd v Macclesfield (15:00) |
| Squires Gate v Wythenshawe Town (15:00) |
| Vauxhall Mtrs v Avro (15:00) |
| Winsford United v Longridge Town (15:00) |
| Saturday 13th November 2021 First Division North |
| AFC Blackpool v Daisy Hill (15:00) |
| Atherton LR v Holker OB (15:00) |
| Bury AFC v South Liverpool (15:00) |
| Campion v AFC Darwen (15:00) |
| Chadderton v Nelson (15:00) |
| Cleator Moor v Ashton Town (15:00) |
| Garstang v Bacup Borough (15:00) |
| Golcar United v Ilkley Town (15:00) |
| Pilkington v Steeton (15:00) |
| Saturday 13th November 2021 First Division South |
| Barnton v Cammell Laird (15:00) |
| Brocton v Alsager Town (15:00) |
| Cheadle Heath v Stafford Town (15:00) |
| Eccleshall v Cheadle Town (15:00) |
| Ellesmere Rngrs v Abbey Hey (15:00) |
| New Mills v Sandbach United (15:00) |
| St Martins v West Didsbury (15:00) |
| Stockport Town v Maine Road (15:00) |
| Wythenshawe Am v Abbey Hulton Utd (15:00) |
| FC Isle of Man v Rocester (18:30) |
| Tuesday 16th November 2021 Premier Division |
| Vauxhall Mtrs v Charnock Richard (19:45) |
| Tuesday 16th November 2021 Cheshire Senior Cup 1st Rnd |
| Crewe Alexandra v Sandbach United (19:15) |
| Tuesday 16th November 2021 Mid Cheshire Senior Cup SF |
| Winsford United v Northwich Vics (19:45) |
