| Tuesday 16th September 2025 Lancashire Challenge Trophy 1st Round |
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| Colne | 3-4 | Nelson |
| Tuesday 16th September 2025 First Division South |
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| Allscott Heath | 3-3 | Shawbury United |
| Alsager Town | 0-1 | Eccleshall |
| Haughmond | 2-3 | Wolverhampton Casuals |
| New Mills | 0-1 | Stockport Georgians |
| Sandbach United | 2-1 | Market Drayton Town |
| Stafford Town | 1-3 | Telford Town |
| Wolverhampton Sporting Community | 2-3 | Foley Meir |
| Monday 15th September 2025 First Division South |
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| Cheadle Heath Nomads | 0-1 | Runcorn Town |
| Saturday 13th September 2025 The Emirates F.A Cup 2nd Qualifying Round |
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| FC United of Manchester | 0-1 | Chadderton |
| Macclesfield | 3-0 | Atherton LR |
| Saturday 13th September 2025 First Division North |
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| AFC Blackpool | 1-1 | Garstang |
| Ashton Athletic | 0-2 | Nelson |
| Colne | 2-2 | Squires Gate |
| Droylsden | 6-1 | Bacup Borough |
| Fulwood Amateurs | 2-1 | MSB Woolton |
| Holker Old Boys | 0-1 | Ashton Town |
| Maghull | 3-0 | Daisy Hill |
| Maine Road | 3-0 | Thornton Cleveleys |
| Steeton | 1-2 | Darwen FC |
| Wed 17th Sep 2025 Premier Division |
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| 19:45 | South Liverpool v Abbey Hey | ||
| First Division South | |||
| 19:45 | Barnton v Ashville | ||
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Friday 19th September 2025 First Division South |
| Market Drayton Town v Shawbury United |
| Saturday 20th September 2025 The Isuzu FA Vase 2nd Qualifying Round |
| AFC Liverpool v Daisy Hill |
| Alsager Town v Coventry United |
| Armthorpe Welfare v Darwen FC |
| Ashville v Penistone Church |
| Barnoldswick Town v Sunderland West End |
| Boro Rangers v Nelson |
| Chadderton v Wakefield AFC |
| Cheadle Town v Barnton |
| City of Liverpool v Charnock Richard |
| Coton Green v Wolverhampton Sporting Community |
| Doncaster City v Prestwich Heys |
| Eccleshall v Stone Old Alleynians |
| Euxton Villa v Sandbach United |
| Fulwood Amateurs v Kendal Town |
| Gornal Athletic v Haughmond |
| Heather St Johns v Foley Meir |
| Holker Old Boys v Route One Rovers |
| Irlam v Bacup Borough |
| Lye Town v Allscott Heath |
| Maghull v Northwich Victoria |
| New Mills v Wythenshawe |
| Northallerton Town v Garstang |
| Nostell Miners Welfare v Droylsden |
| Ramsbottom United v Glasshoughton Welfare |
| Sheffield v Burscough |
| Shildon v Longridge Town |
| Stafford Town v AFC Bridgnorth |
| Stockport Town v Runcorn Town |
| Thornton Cleveleys v Colne |
| Saturday 20th September 2025 The Macron Cup 1st Round |
| Abbey Hey v Stockport Georgians |
| Saturday 20th September 2025 Premier Division |
| Atherton LR v FC St Helens |
| Litherland REMYCA v South Liverpool |
| Pilkington v FC Isle of Man |
| West Didsbury & Chorlton v Glossop North End |
| Saturday 20th September 2025 First Division North |
| Ashton Athletic v MSB Woolton |
| Ashton Town v AFC Blackpool |
| Maine Road v Steeton |
| Saturday 20th September 2025 First Division South |
| Cammell Laird 1907 v Cheadle Heath Nomads |
| Wolverhampton Casuals v Telford Town |
| Sunday 21st September 2025 The Isuzu FA Vase 2nd Qualifying Round |
| Campion v Padiham |
| Premier Division | P | GD | Pts | |
| 1 | Padiham | 10 | 12 | 25 |
| 2 | Ramsbottom United | 10 | 12 | 23 |
| 3 | Wythenshawe | 10 | 9 | 22 |
| 4 | Burscough | 11 | 11 | 20 |
| 5 | FC St Helens | 10 | 7 | 19 |
| 6 | Irlam | 9 | 8 | 18 |
| 7 | Stockport Town | 10 | 3 | 18 |
| 8 | Chadderton | 8 | 13 | 16 |
| 9 | West Didsbury & Chorlton | 9 | 6 | 16 |
| 10 | Pilkington | 11 | -5 | 16 |
| 11 | Atherton LR | 8 | 12 | 15 |
| 12 | Charnock Richard | 10 | 6 | 14 |
| 13 | Cheadle Town | 10 | 2 | 14 |
| 14 | Longridge Town | 9 | 2 | 13 |
| 15 | Prestwich Heys | 10 | 0 | 13 |
| 16 | South Liverpool | 10 | -7 | 12 |
| 17 | Euxton Villa | 11 | -3 | 11 |
| 18 | Barnoldswick Town | 10 | -16 | 11 |
| 19 | Abbey Hey | 10 | -7 | 8 |
| 20 | Glossop North End | 10 | -9 | 8 |
| 21 | City of Liverpool | 9 | -11 | 8 |
| 22 | AFC Liverpool | 10 | -6 | 7 |
| 23 | FC Isle of Man | 12 | -24 | 7 |
| 24 | Litherland REMYCA | 11 | -15 | 4 |
| First Division North | P | GD | Pts | |
| 1 | Droylsden | 8 | 12 | 18 |
| 2 | Maghull | 7 | 8 | 16 |
| 3 | Nelson | 7 | -2 | 15 |
| 4 | Maine Road | 7 | 9 | 12 |
| 5 | Fulwood Amateurs | 7 | 7 | 12 |
| 6 | Steeton | 7 | 2 | 11 |
| 7 | Darwen FC | 7 | 0 | 11 |
| 8 | Holker Old Boys | 7 | 7 | 10 |
| 9 | Ashton Town | 6 | 1 | 10 |
| 10 | Thornton Cleveleys | 7 | 0 | 10 |
| 11 | Colne | 6 | -1 | 8 |
| 12 | Squires Gate | 7 | -4 | 8 |
| 13 | AFC Blackpool | 6 | 0 | 7 |
| 14 | Garstang | 7 | -8 | 6 |
| 15 | Bacup Borough | 4 | -6 | 4 |
| 16 | Daisy Hill | 8 | -7 | 3 |
| 17 | MSB Woolton | 6 | -7 | 3 |
| 18 | Ashton Athletic | 6 | -11 | 3 |
| First Division South | P | GD | Pts | |
| 1 | Runcorn Town | 10 | 18 | 23 |
| 2 | Telford Town | 9 | 12 | 20 |
| 3 | Stockport Georgians | 10 | 7 | 20 |
| 4 | Sandbach United | 9 | 12 | 19 |
| 5 | Stafford Town | 9 | 12 | 19 |
| 6 | Eccleshall | 9 | 6 | 17 |
| 7 | Barnton | 9 | 4 | 17 |
| 8 | New Mills | 10 | 4 | 16 |
| 9 | Allscott Heath | 10 | 1 | 13 |
| 10 | Shawbury United | 9 | -7 | 13 |
| 11 | Foley Meir | 10 | 0 | 12 |
| 12 | Ashville | 8 | 3 | 11 |
| 13 | Wolverhampton Casuals | 10 | -1 | 11 |
| 14 | Cammell Laird 1907 | 9 | -7 | 8 |
| 15 | Cheadle Heath Nomads | 10 | -7 | 8 |
| 16 | Alsager Town | 9 | -8 | 8 |
| 17 | Market Drayton Town | 9 | -10 | 7 |
| 18 | Haughmond | 10 | -14 | 3 |
| 19 | Wolverhampton Sporting Community | 9 | -25 | 3 |
Tables correct as at Tue 16th Sep 2025
