| Wed 20th Oct 2021 Manchester Premier Cup 1st Round |
|
| Avro 5-2 Radcliffe |
| Wed 20th Oct 2021 Mid Cheshire Senior Cup Semi Finals |
|
| Barnton 2-0 1874 Northwich |
| Tue 19th Oct 2021 Lancashire Challenge Trophy 1st Round |
|
| AFC Blackpool 2-6 Bamber Bridge | |
| Nelson 2-3 Charnock Richard | |
| Squires Gate 1-0 Padiham |
| Tue 19th Oct 2021 Manchester Premier Cup 1st Round |
|
| Irlam 1-2 Mossley |
| Tue 19th Oct 2021 West Riding County Cup 1st Round |
|
| Campion 2-1 Bradford Park Avenue |
| Tue 19th Oct 2021 Wirral Senior Cup 2nd Round |
|
| Cammell Laird 1907 1-0 Capenhurst Villa |
| Tue 19th Oct 2021 Premier Division |
|
| AFC Liverpool 4-1 Litherland REMYCA | |
| Ashton Athletic P-P Longridge Town |
| Tue 19th Oct 2021 First Division North |
|
| Golcar United 3-0 Cleator Moor Celtic | |
| Ilkley Town 3-1 Steeton |
| Tue 19th Oct 2021 First Division South |
|
| Cheadle Heath Nomads 3-5 Sandbach United |
| Tue 19th Oct 2021 Cheshire Senior Cup 1st Round |
|
| Vauxhall Motors 2-1 Runcorn Town | |
| Witton Albion 1-3 Winsford United |
| Sat 16th Oct 2021 Premier Division |
|
| Ashton Athletic 3-2 Padiham | |
| Avro 0-2 Longridge Town | |
| Congleton Town 0-2 Burscough | |
| Irlam 3-3 Vauxhall Motors | |
| Lower Breck 2-1 Barnoldswick Town | |
| Runcorn Town 1-4 Charnock Richard | |
| Skelmersdale United 2-1 Prestwich Heys | |
| Squires Gate 0-0 Macclesfield | |
| Winsford United 1-4 AFC Liverpool | |
| Wythenshawe Town 5-0 Litherland REMYCA |
| Sat 16th Oct 2021 First Division North |
|
| Atherton LR 4-3 Steeton | |
| Bacup Borough 1-2 Chadderton | |
| Campion 0-2 Holker Old Boys | |
| Cleator Moor Celtic 5-3 Nelson | |
| Daisy Hill 1-4 Golcar United | |
| St Helens Town 0-5 Bury AFC |
| Sat 16th Oct 2021 First Division South |
|
| Abbey Hey 10-1 St Martins | |
| Abbey Hulton United 3-8 FC Isle of Man | |
| Alsager Town 3-4 Cheadle Heath Nomads | |
| Cheadle Town 3-0 Barnton | |
| Eccleshall 0-4 Maine Road | |
| New Mills 2-0 Brocton | |
| Sandbach United 2-1 Wythenshawe Amateurs | |
| Stafford Town 1-0 Stockport Town | |
| West Didsbury & Chorlton 1-1 Ellesmere Rangers |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Sat 23rd Oct 2021 The Buildbase FA Vase 1st Round |
| Abbey Hey v Parkgate |
| Barton Town v Cleator Moor Celtic |
| Billingham Synthonia v FC Isle of Man |
| Burscough v Garforth Town |
| Consett v Atherton LR |
| Emley AFC v Longridge Town |
| Eynesbury Rovers v Sandbach United |
| Holker Old Boys v Skelmersdale United |
| Newcastle Benfield v Golcar United |
| Pilkington v West Allotment Celtic |
| Prestwich Heys v Penrith |
| Seaham Red Star v Wythenshawe Town |
| Sunderland Ryhope CW v Bury AFC |
| Thornaby v South Liverpool |
| Vauxhall Motors v North Shields |
| Sat 23rd Oct 2021 Premier Division |
| Charnock Richard v Congleton Town |
| Irlam v Lower Breck |
| Litherland REMYCA v Avro |
| Macclesfield v Padiham |
| Runcorn Town v Winsford United |
| Sat 23rd Oct 2021 First Division North |
| Chadderton v Steeton |
| Garstang v Ashton Town |
| Nelson v AFC Darwen |
| Sat 23rd Oct 2021 First Division South |
| Brocton v Cheadle Town |
| Cheadle Heath Nomads v St Martins |
| Eccleshall v Abbey Hulton United |
| Ellesmere Rangers v Alsager Town |
| Maine Road v Cammell Laird 1907 |
| New Mills v Stafford Town |
| Rocester v West Didsbury & Chorlton |
| Stockport Town v Barnton |
| Sun 24th Oct 2021 The Buildbase FA Vase 1st Round |
| AFC Liverpool v Newton Aycliffe (14:00) |
| Premier Division | P | GD | Pts | |
| 1 | Macclesfield | 15 | 12 | 33 |
| 2 | Skelmersdale United | 15 | 17 | 30 |
| 3 | Irlam | 16 | 8 | 29 |
| 4 | Congleton Town | 16 | 11 | 25 |
| 5 | Wythenshawe Town | 15 | 11 | 25 |
| 6 | Charnock Richard | 14 | 16 | 24 |
| 7 | Burscough | 15 | 6 | 24 |
| 8 | Longridge Town | 15 | 6 | 24 |
| 9 | Northwich Victoria | 15 | 5 | 24 |
| 10 | Avro | 15 | 2 | 24 |
| 11 | Vauxhall Motors | 16 | -5 | 24 |
| 12 | Barnoldswick Town | 15 | 5 | 22 |
| 13 | Lower Breck | 15 | -1 | 22 |
| 14 | AFC Liverpool | 15 | -4 | 21 |
| 15 | Squires Gate | 15 | -3 | 17 |
| 16 | Ashton Athletic | 16 | -13 | 17 |
| 17 | Prestwich Heys | 16 | -12 | 16 |
| 18 | Runcorn Town | 15 | -7 | 14 |
| 19 | Winsford United | 15 | -16 | 14 |
| 20 | Padiham | 15 | -4 | 13 |
| 21 | Litherland REMYCA | 16 | -34 | 6 |
| First Division North | P | GD | Pts | |
| 1 | Bury AFC | 13 | 24 | 33 |
| 2 | Golcar United | 13 | 15 | 30 |
| 3 | Holker Old Boys | 13 | 9 | 29 |
| 4 | Pilkington | 13 | 5 | 26 |
| 5 | AFC Blackpool | 14 | 6 | 24 |
| 6 | Chadderton | 13 | 5 | 24 |
| 7 | Bacup Borough | 14 | 11 | 22 |
| 8 | South Liverpool | 14 | -1 | 19 |
| 9 | Campion | 15 | 8 | 18 |
| 10 | Atherton LR | 13 | -3 | 17 |
| 11 | Ashton Town | 13 | -6 | 17 |
| 12 | Garstang | 12 | 3 | 16 |
| 13 | Ilkley Town | 15 | -3 | 16 |
| 14 | Nelson | 14 | -4 | 16 |
| 15 | Steeton | 14 | -1 | 15 |
| 16 | Daisy Hill | 13 | -2 | 14 |
| 17 | AFC Darwen | 13 | -14 | 12 |
| 18 | Cleator Moor Celtic * | 12 | -8 | 5 |
| 19 | St Helens Town | 15 | -44 | 3 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton | 14 | 28 | 36 |
| 2 | New Mills | 14 | 24 | 35 |
| 3 | Abbey Hey | 14 | 28 | 34 |
| 4 | Wythenshawe Amateurs | 15 | 26 | 32 |
| 5 | Sandbach United | 15 | 18 | 29 |
| 6 | FC Isle of Man | 13 | 20 | 25 |
| 7 | Cheadle Town | 13 | 14 | 25 |
| 8 | Stafford Town | 15 | -4 | 24 |
| 9 | Ellesmere Rangers | 14 | 10 | 22 |
| 10 | Cheadle Heath Nomads | 15 | -1 | 22 |
| 11 | Abbey Hulton United | 15 | -10 | 19 |
| 12 | Cammell Laird 1907 | 14 | -8 | 17 |
| 13 | Maine Road | 14 | 3 | 16 |
| 14 | Barnton | 14 | -15 | 15 |
| 15 | Stockport Town | 15 | -1 | 13 |
| 16 | Alsager Town | 14 | -14 | 13 |
| 17 | Brocton | 15 | -26 | 13 |
| 18 | Rocester | 14 | -16 | 10 |
| 19 | Eccleshall | 15 | -20 | 10 |
| 20 | St Martins | 14 | -56 | 2 |
Tables correct as at Wed 20th Oct 2021
