| Saturday 13th August 2005 | First Division | ||
|---|---|---|---|
| Colne | 2-3 | Maine Road | Att: 3 |
| Tuesday 16th August 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 0-1 | Newcastle Town | Att: 1 |
| Saturday 20th August 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 0-4 | Nantwich Town | Att: 4 |
| Saturday 27th August 2005 | F.A. Challenge Cup Preliminary Round | ||
|---|---|---|---|
| Maine Road | 0-2 | Armthorpe Welfare | Att: 40 |
| Tuesday 30th August 2005 | First Division | ||
|---|---|---|---|
| Salford City | 1-1 | Maine Road | Att: 1 |
| Friday 2nd September 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Curzon Ashton | Att: 2 |
| Tuesday 6th September 2005 | First Division | ||
|---|---|---|---|
| Nantwich Town | 1-1 | Maine Road | Att: 1 |
| Saturday 10th September 2005 | First Division | ||
|---|---|---|---|
| Alsager Town | 3-1 | Maine Road | Att: 1 |
| Saturday 17th September 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 0-1 | Skelmersdale United | Att: 1 |
| Thursday 22nd September 2005 | First Division | ||
|---|---|---|---|
| Bacup Borough | 0-2 | Maine Road | Att: 2 |
| Saturday 24th September 2005 | First Division | ||
|---|---|---|---|
| Atherton LR | 0-2 | Maine Road | Att: 2 |
| Sunday 2nd October 2005 | F.A. Carlsberg Vase 2nd Qualifying Round | ||
|---|---|---|---|
| Maine Road | 2-3 | Daisy Hill | Att: 57 |
| Tuesday 4th October 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 3-0 | Stone Dominoes | Att: 0 |
| Saturday 8th October 2005 | First Division | ||
|---|---|---|---|
| Curzon Ashton | 2-2 | Maine Road | Att: 2 |
| Tuesday 11th October 2005 | First Division | ||
|---|---|---|---|
| Formby | 2-3 | Maine Road | Att: 3 |
| Saturday 15th October 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Congleton Town | Att: 2 |
| Saturday 22nd October 2005 | First Division | ||
|---|---|---|---|
| Glossop North End | 2-2 | Maine Road | Att: 2 |
| Saturday 29th October 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 1-0 | Formby | Att: 0 |
| Saturday 19th November 2005 | First Division | ||
|---|---|---|---|
| Atherton Collieries | 1-1 | Maine Road | Att: 1 |
| Saturday 26th November 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 1-3 | Silsden | Att: 3 |
| Saturday 3rd December 2005 | First Division | ||
|---|---|---|---|
| St Helens Town | 2-1 | Maine Road | Att: 1 |
| Saturday 10th December 2005 | First Division | ||
|---|---|---|---|
| Ramsbottom United | 1-1 | Maine Road | Att: 1 |
| Saturday 17th December 2005 | First Division | ||
|---|---|---|---|
| Maine Road | 1-3 | Cammell Laird | Att: 3 |
| Monday 26th December 2005 | First Division | ||
|---|---|---|---|
| Abbey Hey | 2-1 | Maine Road | Att: 1 |
| Monday 2nd January 2006 | First Division | ||
|---|---|---|---|
| Trafford | 0-2 | Maine Road | Att: 2 |
| Saturday 7th January 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 1-2 | St Helens Town | Att: 2 |
| Saturday 14th January 2006 | First Division | ||
|---|---|---|---|
| Newcastle Town | 0-1 | Maine Road | Att: 1 |
| Saturday 21st January 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 3-1 | Atherton LR | Att: 1 |
| Saturday 4th February 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 1-0 | Bacup Borough | Att: 0 |
| Tuesday 7th February 2006 | First Division | ||
|---|---|---|---|
| Cammell Laird | 3-2 | Maine Road | Att: 2 |
| Saturday 18th February 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 2-0 | Trafford | Att: 0 |
| Tuesday 21st February 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 2-0 | Colne | Att: 0 |
| Saturday 25th February 2006 | First Division | ||
|---|---|---|---|
| Squires Gate | 0-0 | Maine Road | Att: 0 |
| Saturday 4th March 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 3-0 | Ramsbottom United | Att: 0 |
| Saturday 11th March 2006 | First Division | ||
|---|---|---|---|
| Congleton Town | 0-1 | Maine Road | Att: 1 |
| Tuesday 14th March 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 4-0 | Squires Gate | Att: 0 |
| Saturday 18th March 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 1-1 | Abbey Hey | Att: 1 |
| Saturday 25th March 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 1-0 | Alsager Town | Att: 0 |
| Saturday 1st April 2006 | First Division | ||
|---|---|---|---|
| Skelmersdale United | 3-1 | Maine Road | Att: 1 |
| Saturday 8th April 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 1-1 | Atherton Collieries | Att: 1 |
| Saturday 15th April 2006 | First Division | ||
|---|---|---|---|
| Silsden | 2-1 | Maine Road | Att: 1 |
| Saturday 22nd April 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 0-4 | Salford City | Att: 4 |
| Saturday 29th April 2006 | First Division | ||
|---|---|---|---|
| Stone Dominoes | 2-7 | Maine Road | Att: 7 |
| Friday 5th May 2006 | First Division | ||
|---|---|---|---|
| Maine Road | 2-2 | Glossop North End | Att: 2 |
