| Saturday 19th August 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 3-1 | Tetley Walker | |
| Tuesday 22nd August 2000 | First Division | ||
|---|---|---|---|
| Darwen | 4-1 | Squires Gate | |
| Saturday 26th August 2000 | F.A. Challenge Cup Extra Preliminary Round | ||
|---|---|---|---|
| Squires Gate | 1-2 | West Auckland Town | |
| Tuesday 29th August 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-1 | Formby | |
| Tuesday 5th September 2000 | First Division | ||
|---|---|---|---|
| Atherton LR | 0-2 | Squires Gate | |
| Saturday 9th September 2000 | F.A. Carlsberg Vase 1st Qualifying Round | ||
|---|---|---|---|
| Squires Gate | 5-0 | Bacup Borough | |
| Saturday 16th September 2000 | First Division | ||
|---|---|---|---|
| Colne | 0-5 | Squires Gate | |
| Saturday 23rd September 2000 | F.A. Carlsberg Vase 2nd Qualifying Round | ||
|---|---|---|---|
| Squires Gate | 4-1 | Tadcaster Albion | |
| Tuesday 26th September 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 5-1 | Padiham | |
| Saturday 30th September 2000 | First Division | ||
|---|---|---|---|
| Bacup Borough | 4-1 | Squires Gate | |
| Saturday 21st October 2000 | F.A. Carlsberg Vase 1st Round | ||
|---|---|---|---|
| Squires Gate | 4-0 | Flixton | |
| Tuesday 24th October 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 5-0 | Ashton Town | |
| Saturday 11th November 2000 | F.A. Carlsberg Vase 2nd Round | ||
|---|---|---|---|
| Squires Gate | 3-2 | Glossop North End | |
| Saturday 18th November 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-1 | Colne | |
| Saturday 25th November 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-0 | Warrington Town | |
| Saturday 9th December 2000 | F.A. Carlsberg Vase 3rd Round | ||
|---|---|---|---|
| Squires Gate | 0-3 | St Helens Town | |
| Saturday 16th December 2000 | First Division | ||
|---|---|---|---|
| Squires Gate | 3-1 | Castleton Gabriels | |
| Saturday 23rd December 2000 | First Division | ||
|---|---|---|---|
| Tetley Walker | 1-2 | Squires Gate | |
| Tuesday 26th December 2000 | First Division | ||
|---|---|---|---|
| Blackpool Mechanics | 1-1 | Squires Gate | |
| Saturday 6th January 2001 | First Division | ||
|---|---|---|---|
| Bootle | 0-1 | Squires Gate | |
| Saturday 13th January 2001 | First Division | ||
|---|---|---|---|
| Formby | 2-1 | Squires Gate | |
| Saturday 27th January 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-1 | Darwen | |
| Saturday 10th February 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 1-0 | Daisy Hill | |
| Tuesday 13th February 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 3-5 | Atherton LR | |
| Saturday 17th February 2001 | First Division | ||
|---|---|---|---|
| Warrington Town | 1-1 | Squires Gate | |
| Tuesday 20th February 2001 | First Division | ||
|---|---|---|---|
| Oldham Town | 0-2 | Squires Gate | |
| Saturday 24th February 2001 | First Division | ||
|---|---|---|---|
| Daisy Hill | 4-4 | Squires Gate | |
| Tuesday 27th February 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 0-1 | Alsager | |
| Tuesday 6th March 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 0-0 | Nelson | |
| Saturday 10th March 2001 | First Division | ||
|---|---|---|---|
| Ashton Town | 1-0 | Squires Gate | |
| Tuesday 13th March 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 1-1 | Bacup Borough | |
| Saturday 17th March 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 4-1 | Oldham Town | |
| Tuesday 20th March 2001 | First Division | ||
|---|---|---|---|
| Holker Old Boys | 2-0 | Squires Gate | |
| Saturday 24th March 2001 | First Division | ||
|---|---|---|---|
| Stone Dominoes | 1-4 | Squires Gate | |
| Tuesday 27th March 2001 | First Division | ||
|---|---|---|---|
| Chadderton | 2-1 | Squires Gate | |
| Saturday 31st March 2001 | First Division | ||
|---|---|---|---|
| Padiham | 1-0 | Squires Gate | |
| Saturday 14th April 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-1 | Bootle | |
| Monday 16th April 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 0-2 | Blackpool Mechanics | |
| Wednesday 18th April 2001 | First Division | ||
|---|---|---|---|
| Castleton Gabriels | 1-3 | Squires Gate | |
| Saturday 21st April 2001 | First Division | ||
|---|---|---|---|
| Alsager | 0-2 | Squires Gate | |
| Thursday 26th April 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 0-0 | Chadderton | |
| Saturday 28th April 2001 | First Division | ||
|---|---|---|---|
| Nelson | 3-3 | Squires Gate | |
| Tuesday 1st May 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 2-1 | Holker Old Boys | |
| Monday 7th May 2001 | First Division | ||
|---|---|---|---|
| Squires Gate | 4-1 | Stone Dominoes | |
