| Saturday 7th August 2010 | Premier Division | ||
|---|---|---|---|
| Squires Gate | 1-4 | Maine Road | Att: 4 |
| Tuesday 10th August 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-0 | Alsager Town | Att: 0 |
| Saturday 14th August 2010 | F.A. Challenge Cup Extra Preliminary Round | ||
|---|---|---|---|
| Runcorn Linnets | 1-1 | Maine Road | Att: 1 |
| Tuesday 17th August 2010 | F.A. Challenge Cup Extra Preliminary Round Replay | ||
|---|---|---|---|
| Maine Road | 3-4 | Runcorn Linnets | Att: 4 |
| Saturday 21st August 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-1 | Silsden | Att: 1 |
| Tuesday 24th August 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Bootle | Att: 2 |
| Saturday 28th August 2010 | Premier Division | ||
|---|---|---|---|
| Formby | 0-3 | Maine Road | Att: 3 |
| Saturday 4th September 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-3 | Ramsbottom United | Att: 3 |
| Tuesday 7th September 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-1 | Glossop North End | Att: 1 |
| Saturday 11th September 2010 | Premier Division | ||
|---|---|---|---|
| Atherton LR | 1-0 | Maine Road | Att: 0 |
| Saturday 18th September 2010 | F.A. Carlsberg Vase 2nd Qualifying Round | ||
|---|---|---|---|
| Maine Road | 1-0 | Barnoldswick Town | Att: 0 |
| Saturday 25th September 2010 | Premier Division | ||
|---|---|---|---|
| Ashton Athletic | 2-4 | Maine Road | Att: 4 |
| Saturday 2nd October 2010 | F.A. Carlsberg Vase 1st Round | ||
|---|---|---|---|
| Maine Road | 2-2 | AFC Blackpool | Att: 2 |
| (After Extra Time, 2-2 after 90 mins) | |||
| Tuesday 5th October 2010 | F.A. Carlsberg Vase 1st Round Replay | ||
|---|---|---|---|
| AFC Blackpool | 2-1 | Maine Road | Att: 1 |
| Saturday 9th October 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-0 | New Mills | Att: 0 |
| Tuesday 12th October 2010 | Premier Division | ||
|---|---|---|---|
| St Helens Town | 3-3 | Maine Road | Att: 3 |
| Saturday 16th October 2010 | Premier Division | ||
|---|---|---|---|
| Barnoldswick Town | 2-0 | Maine Road | Att: 0 |
| Saturday 23rd October 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-2 | Atherton LR | Att: 2 |
| Tuesday 26th October 2010 | Manchester Premier Cup 1st Round | ||
|---|---|---|---|
| Maine Road | 1-2 | Ashton United | Att: 2 |
| Saturday 30th October 2010 | Premier Division | ||
|---|---|---|---|
| Alsager Town | 0-1 | Maine Road | Att: 1 |
| Saturday 6th November 2010 | League Challenge Cup 2nd Round | ||
|---|---|---|---|
| Maine Road | 1-2 | Winsford United | Att: 2 |
| Saturday 13th November 2010 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-0 | Rossendale United | Att: 0 |
| Saturday 20th November 2010 | Premier Division | ||
|---|---|---|---|
| Ramsbottom United | 2-1 | Maine Road | Att: 1 |
| Monday 3rd January 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-2 | Winsford United | Att: 2 |
| Saturday 8th January 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Squires Gate | Att: 2 |
| Saturday 15th January 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-2 | Runcorn Linnets | Att: 2 |
| Saturday 29th January 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-3 | Flixton | Att: 3 |
| Tuesday 1st February 2011 | Premier Division | ||
|---|---|---|---|
| Bootle | 2-1 | Maine Road | Att: 1 |
| Saturday 12th February 2011 | Premier Division | ||
|---|---|---|---|
| Padiham | 1-1 | Maine Road | Att: 1 |
| Monday 14th February 2011 | Premier Division | ||
|---|---|---|---|
| New Mills | 4-4 | Maine Road | Att: 4 |
| Saturday 19th February 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Bacup Borough | Att: 2 |
| Tuesday 22nd February 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-3 | St Helens Town | Att: 3 |
| Saturday 26th February 2011 | Premier Division | ||
|---|---|---|---|
| Glossop North End | 1-2 | Maine Road | Att: 2 |
| Tuesday 1st March 2011 | Premier Division | ||
|---|---|---|---|
| Winsford United | 0-2 | Maine Road | Att: 2 |
| Saturday 5th March 2011 | Premier Division | ||
|---|---|---|---|
| Stone Dominoes | 1-3 | Maine Road | Att: 3 |
| Tuesday 8th March 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-1 | Congleton Town | Att: 1 |
| Saturday 12th March 2011 | Premier Division | ||
|---|---|---|---|
| Silsden | 1-3 | Maine Road | Att: 3 |
| Wednesday 16th March 2011 | Premier Division | ||
|---|---|---|---|
| Bacup Borough | 0-0 | Maine Road | Att: 0 |
| Saturday 19th March 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-2 | Padiham | Att: 2 |
| Tuesday 22nd March 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-1 | Barnoldswick Town | Att: 1 |
| Saturday 26th March 2011 | Premier Division | ||
|---|---|---|---|
| Runcorn Linnets | 2-1 | Maine Road | Att: 1 |
| Tuesday 29th March 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-2 | Stone Dominoes | Att: 2 |
| Saturday 2nd April 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-1 | Colne | Att: 1 |
| Tuesday 5th April 2011 | Premier Division | ||
|---|---|---|---|
| Flixton | 3-0 | Maine Road | Att: 0 |
| Saturday 9th April 2011 | Premier Division | ||
|---|---|---|---|
| Congleton Town | 1-1 | Maine Road | Att: 1 |
| Wednesday 13th April 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-4 | Formby | Att: 4 |
| Saturday 16th April 2011 | Premier Division | ||
|---|---|---|---|
| Colne | 2-1 | Maine Road | Att: 1 |
| Saturday 23rd April 2011 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-0 | Ashton Athletic | Att: 0 |
| Saturday 30th April 2011 | Premier Division | ||
|---|---|---|---|
| Rossendale United | 1-0 | Maine Road | Att: 0 |
