| Sat 30/07/22 | Barnoldswick Town v Winsford United | 3-1 | | | | |  |
| Tue 02/08/22 | Barnoldswick Town v Kendal Town | 4-1 | | | | | |
| Sat 06/08/22 | Barnoldswick Town v Albion Sports | 1-1 | | | | | |
| Wed 10/08/22 | Albion Sports v Barnoldswick Town | 2-2 | | | | | |
| Sat 13/08/22 | West Didsbury & Chorlton v Barnoldswick Town | 5-2 | | | | | |
| Tue 16/08/22 | Barnoldswick Town v Avro | 0-3 | | | | | |
| Sun 21/08/22 | Burscough v Barnoldswick Town | 2-3 | | | | | |
| Tue 23/08/22 | Barnoldswick Town v Charnock Richard | 2-2 | | | | | |
| Mon 29/08/22 | Barnoldswick Town v Prestwich Heys | 3-5 | | | |  | |
| Sat 03/09/22 | FC Isle of Man v Barnoldswick Town | 3-3 | | | | | |
| Sat 24/09/22 | AFC Blackpool v Barnoldswick Town * | 0-3 | | | | | |
| Tue 27/09/22 | Longridge Town v Barnoldswick Town | 2-2 | | | | | |
| Sat 01/10/22 | Barnoldswick Town v Ashton Athletic | 1-2 | | | | | |
| Tue 04/10/22 | Selby Town v Barnoldswick Town | 2-4 | | | | | |
| Fri 07/10/22 | AFC Liverpool v Barnoldswick Town | 3-0 | | | | | |
| Sat 15/10/22 | Barnoldswick Town v Stockport Town | 2-1 | | | | | |
| Sat 22/10/22 | Barnoldswick Town v Selby Town | 5-4 | | | | | |
| Sat 29/10/22 | Lower Breck v Barnoldswick Town | 1-0 | | | | | |
| Sat 05/11/22 | Barnoldswick Town v Vauxhall Motors * | 1-1 | | | | | |
| Tue 08/11/22 | Barnoldswick Town v West Didsbury & Chorlton | 2-1 |  | | | | |
| Sat 12/11/22 | Barnoldswick Town v Horden Community Welfare | 1-2 | | | | | |
| Tue 15/11/22 | Wythenshawe Town v Barnoldswick Town | 2-3 | | | | | |
| Sat 19/11/22 | Barnoldswick Town v Abbey Hey | 1-1 | | | | | |
| Sat 26/11/22 | Barnoldswick Town v Wakefield AFC * | 8-3 | | | | | |
| Wed 30/11/22 | Kendal Town v Barnoldswick Town * | 3-1 | | | | | |
| Sat 03/12/22 | Barnoldswick Town v FC Isle of Man | 0-1 | | | | | |
| Tue 06/12/22 | Bury AFC v Barnoldswick Town | 2-0 | | | | | |
