| Sat 26/07/25 | Runcorn Town v Market Drayton Town | 4-0 | | | | | | |
| Tue 29/07/25 | Shawbury United v Market Drayton Town | 3-2 | | | |  | | |
| Sat 02/08/25 | Market Drayton Town v Stockport Georgians | 3-1 | | | | | | |
| Sat 09/08/25 | Foley Meir v Market Drayton Town | 2-0 | | | | | | |
| Sat 16/08/25 | Market Drayton Town v Ashville | 0-3 | | | | | | |
| Sat 23/08/25 | Market Drayton Town v Haughmond (CUP) | 1-3 | | | | | | |
| Sat 06/09/25 | Cheadle Heath Nomads v Market Drayton Town | 2-3 |  | | | | |  |
| Tue 09/09/25 | Market Drayton Town v Wolverhampton Casuals | 2-2 | | | | | | |
| Sat 13/09/25 | Market Drayton Town v Allscott Heath | 1-3 | | | | | | |
| Tue 16/09/25 | Sandbach United v Market Drayton Town * | 2-1 | | | | | | |
| Fri 19/09/25 | Market Drayton Town v Shawbury United | 3-3 | | | | | | |
| Sat 27/09/25 | Eccleshall v Market Drayton Town (CUP) * | 3-1 | | | | | | |
| Sat 04/10/25 | Market Drayton Town v Stafford Town | 3-3 | | | | | | |
| Tue 07/10/25 | Shawbury United v Market Drayton Town (CUP) * | 3-3 | | | | | | |
| Sat 11/10/25 | Market Drayton Town v Alsager Town * | 1-4 | | | | | | |
| Sat 18/10/25 | Telford Town v Market Drayton Town * | 1-0 | | | | | | |
| Tue 21/10/25 | Market Drayton Town v Haughmond | 5-2 | | | | | | |
| Sat 25/10/25 | Stockport Georgians v Market Drayton Town | 1-1 | | | | | | |
| Tue 28/10/25 | Stafford Town v Market Drayton Town (CUP) * | 5-2 | | | | | | |
| Sat 01/11/25 | New Mills v Market Drayton Town | 3-1 | | | | | | |
| Sat 15/11/25 | Allscott Heath v Market Drayton Town * | 2-2 | | | | | | |
| Sat 22/11/25 | Wolverhampton Sporting Community v Market Drayton Town * | 1-3 | | | | | | |
| Sat 29/11/25 | Market Drayton Town v Barnton * | 2-1 | | | | | | |
| Sat 13/12/25 | Wolverhampton Casuals v Market Drayton Town * | 0-0 | |  | | | | |
