| Sat 30/07/22 | Wythenshawe Amateurs v Alsager Town | 4-0 | | | | | |
| Sat 06/08/22 | Wythenshawe Amateurs v Stockport Town | 1-0 | | | | | |
| Tue 09/08/22 | New Mills v Wythenshawe Amateurs | 1-3 | | | | | |
| Sat 13/08/22 | Wythenshawe Amateurs v Brocton | 2-0 | | | | | |
| Tue 16/08/22 | Wythenshawe Amateurs v Abbey Hulton United | 3-1 | | | | | |
| Sat 20/08/22 | Cheadle Town v Wythenshawe Amateurs | 3-2 | | | | | |
| Sat 27/08/22 | Wythenshawe Amateurs v Cammell Laird 1907 | 1-1 | | | | | |
| Mon 29/08/22 | Wythenshawe Amateurs v Foley Meir | 7-2 | | | | | |
| Sat 03/09/22 | Rocester v Wythenshawe Amateurs | 1-3 | | | | | |
| Tue 06/09/22 | Wythenshawe Amateurs v Stockport Georgians | 2-0 | | | | | |
| Sat 17/09/22 | Ellesmere Rangers v Wythenshawe Amateurs | 3-3 | | | | |  |
| Sat 24/09/22 | Wythenshawe Amateurs v Ashville | 5-0 | | | | | |
| Sat 01/10/22 | Wythenshawe Amateurs v Cheadle Heath Nomads | 0-0 | | | | | |
| Sat 08/10/22 | Wythenshawe Amateurs v New Mills | 0-0 | | | | | |
| Sat 15/10/22 | Maine Road v Wythenshawe Amateurs | 0-0 | | | | | |
| Sat 22/10/22 | Barnton v Wythenshawe Amateurs | 0-1 | | | | | |
| Sat 29/10/22 | Wythenshawe Amateurs v Cheadle Town | 2-0 | | | | | |
| Sat 05/11/22 | Wythenshawe Amateurs v Sandbach United | 2-1 | | | | | |
| Tue 08/11/22 | Cammell Laird 1907 v Wythenshawe Amateurs | 0-1 | | | | | |
| Sat 19/11/22 | Lower Breck v Wythenshawe Amateurs | 4-0 | | | | | |
| Mon 26/12/22 | Wythenshawe Amateurs v Maine Road | 3-0 | | | | | |
| Sat 07/01/23 | Abbey Hey v Wythenshawe Amateurs | 0-1 | | | | | |
| Sat 14/01/23 | Wythenshawe Amateurs v Cammell Laird 1907 | 2-1 | | | | | |
| Tue 17/01/23 | Wythenshawe Amateurs v Stafford Town | 2-0 | | | | | |
| Tue 24/01/23 | Cheadle Heath Nomads v Wythenshawe Amateurs | 2-0 | | | | | |
| Sat 28/01/23 | Wythenshawe Amateurs v New Mills | 3-4 | | | | | |
| Tue 31/01/23 | Stafford Town v Wythenshawe Amateurs | 1-4 | | | | | |
| Sat 04/02/23 | Wythenshawe Amateurs v Rocester | 3-1 | | | | | |
| Wed 08/02/23 | Eccleshall v Wythenshawe Amateurs | 0-5 | | | | | |
| Sat 11/02/23 | Abbey Hulton United v Wythenshawe Amateurs | 1-2 | | |  | | |
| Sat 18/02/23 | Wythenshawe Amateurs v Ellesmere Rangers | 2-0 | | | | | |
| Tue 21/02/23 | Stockport Georgians v Wythenshawe Amateurs | 0-0 | | | | | |
| Sat 25/02/23 | Alsager Town v Wythenshawe Amateurs | 1-2 | | | | | |
| Sat 04/03/23 | Ashville v Wythenshawe Amateurs | 0-1 | | | | | |
| Sat 11/03/23 | Stockport Town v Wythenshawe Amateurs | 1-2 | | | | | |
| Sat 18/03/23 | Brocton v Wythenshawe Amateurs | - | | | | | |
