| Sat 06/08/22 | Trafford v AFC Liverpool * | 6-0 | | | | | |
| Tue 09/08/22 | Burscough v AFC Liverpool | 1-6 |  | | | | |
| Sat 13/08/22 | AFC Liverpool v Northwich Victoria | 1-3 | | | | | |
| Tue 16/08/22 | Longridge Town v AFC Liverpool | 0-3 | | | | |  |
| Tue 23/08/22 | Ashton Athletic v AFC Liverpool | 1-2 | | | | | |
| Mon 29/08/22 | AFC Liverpool v FC Isle of Man | 5-2 | | | | | |
| Sat 03/09/22 | Prestwich Heys v AFC Liverpool | 0-2 | | | | | |
| Wed 07/09/22 | AFC Liverpool v Winsford United | 1-2 | | | | | |
| Tue 13/09/22 | Charnock Richard v AFC Liverpool | 3-3 | | | | | |
| Sun 16/10/22 | AFC Liverpool v FC Isle of Man * | 1-0 | | | | | |
| Thu 20/10/22 | Lower Breck v AFC Liverpool | 2-0 | | | | | |
| Sat 22/10/22 | Winsford United v AFC Liverpool | 1-1 | | |  | | |
| Sat 29/10/22 | AFC Liverpool v Avro | 1-0 | | | | | |
| Sat 05/11/22 | AFC Liverpool v Wythenshawe Town | 1-3 | | | | | |
| Tue 08/11/22 | Congleton Town v AFC Liverpool | 2-0 | | | | | |
| Sun 13/11/22 | AFC Liverpool v FC St Helens | 1-1 | | | | | |
| Sat 19/11/22 | Wythenshawe Town v AFC Liverpool * | 5-1 | | | | | |
| Sat 26/11/22 | Litherland REMYCA v AFC Liverpool | 0-0 | | | | | |
| Sat 03/12/22 | AFC Liverpool v Cheadle Town | 2-1 | | | | | |
| Sat 17/12/22 | FC Isle of Man v AFC Liverpool | 0-2 | | | | | |
| Wed 18/01/23 | AFC Liverpool v Kendal Town | 5-0 | | | | | |
| Wed 25/01/23 | Avro v AFC Liverpool * | 2-2 | | | | | |
| Sat 28/01/23 | Eccleshill United v AFC Liverpool | 0-0 | | | | | |
| Wed 01/02/23 | Northwich Victoria v AFC Liverpool | 2-0 | | | | | |
| Wed 08/02/23 | AFC Liverpool v Longridge Town * | 3-2 | | | | | |
