| Sat 26/07/25 | West Didsbury & Chorlton v Pilkington | 2-5 | | | | | | |
| Tue 29/07/25 | Glossop North End v West Didsbury & Chorlton | 1-2 |  | | | | | |
| Sat 02/08/25 | Winsford United v West Didsbury & Chorlton (CUP) | 1-1 | | | | | | |
| Wed 06/08/25 | West Didsbury & Chorlton v Winsford United (CUP) * | 1-1 | | | | | | |
| Sat 09/08/25 | West Didsbury & Chorlton v Euxton Villa | 3-3 | | | | | | |
| Wed 13/08/25 | West Didsbury & Chorlton v Atherton LR | 0-1 | | | | | | |
| Mon 25/08/25 | City of Liverpool v West Didsbury & Chorlton | 1-4 | | | | | | |
| Sat 30/08/25 | West Didsbury & Chorlton v Runcorn Linnets (CUP) | 0-2 | | | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | |  | | | | |
| Tue 09/09/25 | Prestwich Heys v West Didsbury & Chorlton | 2-1 | | | | | | |
| Sat 13/09/25 | West Didsbury & Chorlton v Barnoldswick Town * | 4-0 | | | | | | |
| Tue 16/09/25 | Irlam v West Didsbury & Chorlton | 2-4 | | | | | | |
| Sat 20/09/25 | West Didsbury & Chorlton v Glossop North End | 1-2 | | | | | | |
| Tue 23/09/25 | Chadderton v West Didsbury & Chorlton | 1-3 | | | | | | |
| Sat 27/09/25 | West Didsbury & Chorlton v Cheadle Heath Nomads (CUP) | 4-0 | | | | | | |
| Wed 01/10/25 | West Didsbury & Chorlton v AFC Liverpool | 4-3 | | | | | | |
| Wed 08/10/25 | West Didsbury & Chorlton v Litherland REMYCA * | 3-0 | | | | | | |
| Sat 11/10/25 | West Didsbury & Chorlton v Abbey Hey (CUP) | 4-0 | | | | | | |
| Tue 14/10/25 | Charnock Richard v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 18/10/25 | Atherton LR v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 25/10/25 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | | |
| Wed 29/10/25 | West Didsbury & Chorlton v Irlam | 2-5 | | | | | | |
| Sat 01/11/25 | Pilkington v West Didsbury & Chorlton | 0-5 | | | | | | |
| Tue 04/11/25 | Cheadle Town v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 08/11/25 | Brigg Town v West Didsbury & Chorlton (CUP) | 1-2 | | | | | | |
| Wed 12/11/25 | West Didsbury & Chorlton v City of Liverpool | 6-1 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton | 1-3 | | | |  | | |
| Wed 19/11/25 | West Didsbury & Chorlton v Clitheroe (CUP) | 0-5 | | | | | | |
| Sat 22/11/25 | Ramsbottom United v West Didsbury & Chorlton (CUP) | 1-2 | | | | | | |
| Wed 26/11/25 | West Didsbury & Chorlton v Stalybridge Celtic (CUP) * | 3-1 | | | | | | |
| Sat 29/11/25 | West Didsbury & Chorlton v Charnock Richard | - | | | | | | |
| Wed 03/12/25 | West Didsbury & Chorlton v Stockport Town | 1-3 | | | | | | |
| Sat 06/12/25 | Rossington Main v West Didsbury & Chorlton (CUP) | 0-3 | | | | | | |
| Fri 12/12/25 | Abbey Hey v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 20/12/25 | West Didsbury & Chorlton v Chadderton | - | | | | | | |
| Fri 26/12/25 | West Didsbury & Chorlton v Wythenshawe | 0-1 | | | | | | |
| Wed 28/01/26 | West Didsbury & Chorlton v Abbey Hey * | 3-1 | | | | | | |
| Sat 31/01/26 | Burscough v West Didsbury & Chorlton * | 1-0 | | | | | | |
| Tue 10/02/26 | Padiham v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 14/02/26 | West Didsbury & Chorlton v Winsford United (CUP) | 4-1 | | | | | | |
| Wed 18/02/26 | West Didsbury & Chorlton v South Liverpool | 4-0 | | | | | | |
| Sat 21/02/26 | West Didsbury & Chorlton v Ramsbottom United | - | | | | | | |
| Tue 24/02/26 | FC St Helens v West Didsbury & Chorlton | 3-0 | | | | | | |
| Sat 28/02/26 | Hallen v West Didsbury & Chorlton (CUP) | 1-1 | | | | | | |
| Sat 07/03/26 | West Didsbury & Chorlton v FC St Helens | 1-1 | | | | | | |
| Wed 11/03/26 | Litherland REMYCA v West Didsbury & Chorlton | 1-1 | | | | | | |
| Sat 14/03/26 | Longridge Town v West Didsbury & Chorlton | 0-4 | | | | | | |
| Tue 17/03/26 | Ramsbottom United v West Didsbury & Chorlton | 3-1 | | | | | | |
| Sat 21/03/26 | West Didsbury & Chorlton v Padiham | 1-2 | | | | | | |
| Wed 25/03/26 | West Didsbury & Chorlton v Ramsbottom United | - | | | | | | |
| Sat 28/03/26 | AFC Liverpool v West Didsbury & Chorlton | 4-1 | | | | | | |
| Wed 01/04/26 | West Didsbury & Chorlton v Thornton Cleveleys (CUP) | 4-1 | | | | | | |
| Sat 04/04/26 | Burscough v West Didsbury & Chorlton (CUP) | 0-0 | | | | | | |
| Mon 06/04/26 | Wythenshawe v West Didsbury & Chorlton | 1-0 | | | | | | |
| Wed 08/04/26 | Barnoldswick Town v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 11/04/26 | West Didsbury & Chorlton v Prestwich Heys | 5-2 | | | | | | |
| Mon 13/04/26 | West Didsbury & Chorlton v Cheadle Town | 1-2 | | | | | | |
| Wed 15/04/26 | West Didsbury & Chorlton v Ramsbottom United | 1-3 | | | | | | |
| Sat 18/04/26 | Euxton Villa v West Didsbury & Chorlton | 1-2 | | | | | | |
