| Sat 30/07/22 | Bury AFC v Litherland REMYCA * | 1-0 | | | | | |
| Wed 10/08/22 | Litherland REMYCA v Prestwich Heys * | 3-4 | | | | | |
| Sat 13/08/22 | Litherland REMYCA v Squires Gate | 0-2 | | |  | | |
| Wed 17/08/22 | Litherland REMYCA v Wythenshawe Town | 1-3 | | | | | |
| Tue 23/08/22 | Longridge Town v Litherland REMYCA * | 0-1 | | | | | |
| Sat 27/08/22 | Litherland REMYCA v Staveley Miners Welfare | 2-0 | | | | | |
| Mon 29/08/22 | Padiham v Litherland REMYCA | 5-1 | | | | | |
| Wed 14/09/22 | Litherland REMYCA v Lower Breck * | 1-0 | | | | | |
| Sat 17/09/22 | Barnoldswick Town v Litherland REMYCA | 3-2 | | | | | |
| Wed 21/09/22 | AFC Liverpool v Litherland REMYCA * | 1-0 | | | | | |
| Sat 24/09/22 | Litherland REMYCA v Charnock Richard | 3-2 | | | | | |
| Wed 28/09/22 | Northwich Victoria v Litherland REMYCA | 2-2 | | | | | |
| Sat 01/10/22 | Litherland REMYCA v Kendal Town | 2-1 | | | | | |
| Sat 08/10/22 | Litherland REMYCA v Irlam * | 0-4 | | | | | |
| Sat 15/10/22 | Litherland REMYCA v Lower Breck * | 0-4 | | | | | |
| Sat 22/10/22 | Vauxhall Motors v Litherland REMYCA | 2-1 | | | | | |
| Wed 02/11/22 | Avro v Litherland REMYCA | 1-0 | | | | | |
| Sat 05/11/22 | Congleton Town v Litherland REMYCA | 2-1 | | | | | |
| Wed 30/11/22 | South Liverpool v Litherland REMYCA * | 2-3 | | | | | |
| Sat 03/12/22 | Litherland REMYCA v Avro * | 0-1 | | | | | |
| Sat 10/12/22 | FC Isle of Man v Litherland REMYCA | 2-3 | | | | | |
| Sat 07/01/23 | Litherland REMYCA v Burscough | 2-1 | | | | | |
| Sat 04/02/23 | Litherland REMYCA v Bury AFC | 0-1 | | | | | |
| Wed 08/02/23 | Litherland REMYCA v Barnoldswick Town * | 2-1 | | | | | |
| Sat 11/02/23 | Burscough v Litherland REMYCA * | 2-3 | | | | | |
| Tue 14/02/23 | Runcorn Linnets v Litherland REMYCA | 2-1 | | | | | |
| Sat 18/02/23 | Wythenshawe Town v Litherland REMYCA | 3-0 | | | | | |
| Sat 04/03/23 | Litherland REMYCA v Longridge Town | 1-1 | | | | | |
| Sat 11/03/23 | Kendal Town v Litherland REMYCA * | 2-2 | | | | | |
| Sat 18/03/23 | Ashton Athletic v Litherland REMYCA | 0-5 | | | | | |
| Sat 01/04/23 | Irlam v Litherland REMYCA * | 0-2 | | | | | |
| Mon 10/04/23 | Winsford United v Litherland REMYCA * | 1-2 | | | | | |
| Sat 22/04/23 | Lower Breck v Litherland REMYCA * | 0-1 | | | | | |
