| Sat 26/07/25 | West Didsbury & Chorlton v Pilkington | 2-5 |  | | | | |  |
| Tue 29/07/25 | Irlam v Pilkington | 1-2 | | | | | | |
| Sat 02/08/25 | Pilkington v Longridge Town (CUP) | 2-2 | | | | | | |
| Tue 05/08/25 | Longridge Town v Pilkington (CUP) | 8-1 | | | | | | |
| Sat 09/08/25 | Pilkington v Abbey Hey | 2-4 | | | | | | |
| Tue 12/08/25 | Charnock Richard v Pilkington | 4-0 | | | | | | |
| Sat 16/08/25 | Pilkington v South Liverpool | 1-6 | | | | | | |
| Sat 23/08/25 | Brigg Town v Pilkington (CUP) | 3-2 | | | | | | |
| Mon 25/08/25 | Pilkington v AFC Liverpool | 0-4 | | | | | | |
| Sat 30/08/25 | Pilkington v Barnoldswick Town | 3-3 | | | | | | |
| Sat 06/09/25 | Glossop North End v Pilkington | 0-4 | |  | |  | | |
| Wed 10/09/25 | Pilkington v Stockport Town | 1-2 | | | | | | |
| Sat 13/09/25 | Pilkington v Longridge Town | 5-3 | | | | | | |
| Tue 16/09/25 | City of Liverpool v Pilkington | 3-4 | | | | | | |
| Sat 27/09/25 | Pilkington v Atherton LR (CUP) | 0-1 | | | | | | |
| Sat 04/10/25 | Pilkington v Cheadle Town | 1-2 | | | | | | |
| Tue 07/10/25 | Burscough v Pilkington | 3-1 | | | | | | |
| Sat 11/10/25 | Pilkington v Glossop North End | 2-0 | | | | | | |
| Tue 14/10/25 | Prestwich Heys v Pilkington | 2-0 | | | | | | |
| Sat 18/10/25 | Pilkington v City of Liverpool | 1-3 | | | | | | |
| Sat 25/10/25 | Barnoldswick Town v Pilkington | 6-1 | | | | | | |
| Tue 28/10/25 | Warrington Rylands 1906 v Pilkington (CUP) | 6-1 | | | | | | |
| Sat 01/11/25 | Pilkington v West Didsbury & Chorlton | 0-5 | | | | | | |
| Sat 08/11/25 | FC Isle of Man v Pilkington | 1-2 | | | | | | |
| Sat 22/11/25 | Pilkington v Padiham | 1-10 | | | | | | |
| Sat 06/12/25 | Pilkington v Euxton Villa | - | | | | | | |
| Tue 09/12/25 | Chadderton v Pilkington | 6-1 | | | | | | |
| Sat 13/12/25 | Pilkington v Atherton LR | 0-1 | | | | | | |
