| Sat 28/08/21 | Wythenshawe Town v Lower Breck | 3-2 | | | | | |
| Mon 30/08/21 | Ashton Athletic v Lower Breck | 1-0 | | | | | |
| Sat 04/09/21 | Lower Breck v Longridge Town | 1-5 | | | | | |
| Thu 09/09/21 | Lower Breck v Vauxhall Motors | 3-1 | | |  | | |
| Sat 11/09/21 | Prestwich Heys v Lower Breck | 3-1 | | | | | |
| Tue 14/09/21 | Runcorn Town v Lower Breck * | 2-2 | | | | | |
| Sat 18/09/21 | Lower Breck v Winsford United * | 4-3 | | | | | |
| Thu 23/09/21 | Lower Breck v Charnock Richard | 4-0 | | | | | |
| Sat 02/10/21 | Avro v Lower Breck | 3-2 | | | | | |
| Sat 09/10/21 | Lower Breck v Skelmersdale United | 0-2 | | | | | |
| Sat 23/10/21 | Irlam v Lower Breck * | 1-4 | | | | | |
| Fri 29/10/21 | Lower Breck v Macclesfield * | 1-3 | | | | | |
| Sat 06/11/21 | Congleton Town v Lower Breck * | 3-2 | | | | | |
| Thu 11/11/21 | Lower Breck v Padiham * | 0-0 | | | | | |
| Sat 13/11/21 | Lower Breck v Northwich Victoria * | 5-1 |  | | | | |
| Sat 20/11/21 | Lower Breck v Irlam * | 4-0 | | | | | |
| Fri 26/11/21 | Litherland REMYCA v Lower Breck * | 1-2 | | | | | |
| Sat 04/12/21 | Lower Breck v Runcorn Town * | 3-1 | | | | | |
| Sat 18/12/21 | Northwich Victoria v Lower Breck * | 7-0 | | | | | |
| Tue 28/12/21 | Lower Breck v AFC Liverpool | 2-2 | | | | | |
| Mon 03/01/22 | Lower Breck v Wythenshawe Town * | 0-2 | | | | | |
| Wed 19/01/22 | Longridge Town v Lower Breck | 6-1 | | | | | |
| Sat 22/01/22 | Lower Breck v Avro | 0-2 | | | | | |
| Tue 25/01/22 | Vauxhall Motors v Lower Breck * | 2-1 | | | | | |
| Sat 29/01/22 | Charnock Richard v Lower Breck * | 4-4 | | | | | |
| Sat 05/02/22 | Lower Breck v Ashton Athletic | 1-4 | | | | |  |
| Sat 12/02/22 | Macclesfield v Lower Breck * | 4-0 | | | | | |
| Thu 17/02/22 | Lower Breck v Squires Gate * | 1-3 | | | | | |
| Sat 19/02/22 | Lower Breck v Congleton Town * | 2-2 | | | | | |
| Sat 26/02/22 | Padiham v Lower Breck | 2-0 | | | | | |
| Sat 12/03/22 | Lower Breck v Prestwich Heys | 3-3 | | | | | |
| Thu 17/03/22 | Lower Breck v Wythenshawe Town | 1-4 | | | | | |
| Sat 19/03/22 | Barnoldswick Town v Lower Breck | 1-0 | | | | | |
| Sat 26/03/22 | Winsford United v Lower Breck | 3-0 | | | | | |
| Sat 02/04/22 | Skelmersdale United v Lower Breck | 2-0 | | | | | |
