| Sat 31/07/21 | Ilkley Town v Bury AFC | 2-4 | | |  | | |
| Tue 03/08/21 | Bacup Borough v Ilkley Town | 3-0 | | | | | |
| Sat 07/08/21 | Ashton Town v Ilkley Town | 3-2 | | | | | |
| Sat 14/08/21 | Ilkley Town v Holker Old Boys | 1-3 | | | | | |
| Tue 17/08/21 | Chadderton v Ilkley Town | 2-1 | | | | | |
| Sat 21/08/21 | Ilkley Town v AFC Darwen | 6-0 | | | | | |
| Sat 28/08/21 | South Liverpool v Ilkley Town | 2-3 | | | | | |
| Mon 30/08/21 | Ilkley Town v Nelson | 1-2 | | | | | |
| Sat 04/09/21 | Garstang v Ilkley Town | 6-2 | | | | | |
| Sat 11/09/21 | Ilkley Town v Penrith | 1-2 | | | | | |
| Tue 28/09/21 | Campion v Ilkley Town * | 3-3 | | | | | |
| Sat 09/10/21 | Pilkington v Ilkley Town * | 4-2 | | | | | |
| Tue 12/10/21 | Ilkley Town v FC Halifax Town * | 1-3 | | | | | |
| Sat 30/10/21 | Daisy Hill v Ilkley Town | - | | | | | |
| Sat 20/11/21 | Atherton LR v Ilkley Town | 2-1 | | | | | |
| Mon 22/11/21 | Daisy Hill v Ilkley Town | 3-2 | | | | | |
| Sat 04/12/21 | Cleator Moor Celtic v Ilkley Town * | 3-0 | | | | | |
| Sat 11/12/21 | Ilkley Town v Ashton Town * | 4-3 | | | | | |
| Sat 15/01/22 | St Helens Town v Ilkley Town * | 2-5 | | | | | |
| Sat 22/01/22 | Ilkley Town v Chadderton | 1-2 | | | | | |
| Sat 29/01/22 | Nelson v Ilkley Town | 3-2 | | | | | |
| Tue 01/02/22 | Bury AFC v Ilkley Town | 2-1 | | | | | |
| Sat 05/02/22 | Ilkley Town v Campion | 1-2 | | | | | |
| Sat 12/02/22 | Steeton v Ilkley Town | 2-1 | | | | | |
| Tue 22/02/22 | Steeton v Ilkley Town | 1-1 | | | | | |
| Sat 26/02/22 | Ilkley Town v Golcar United | 6-2 | | | | | |
| Sun 06/03/22 | Ilkley Town v Garstang | 0-0 | | | | | |
| Wed 09/03/22 | Garstang v Ilkley Town | 0-1 | | | | | |
| Sat 12/03/22 | Ilkley Town v Pilkington | 3-1 | | | | | |
| Wed 23/03/22 | AFC Darwen v Ilkley Town | 3-2 | | | | | |
| Sat 26/03/22 | Holker Old Boys v Ilkley Town | 1-0 | | | | | |
| Sat 02/04/22 | Ilkley Town v AFC Blackpool | 2-0 | | | | | |
| Sat 09/04/22 | Bacup Borough v Ilkley Town | 3-3 | | | | | |
| Mon 18/04/22 | Golcar United v Ilkley Town | 1-2 | | | | | |
| Sat 23/04/22 | Ilkley Town v Abbey Hulton United | 2-0 | | | | | |
| Sat 07/05/22 | Cammell Laird 1907 v Ilkley Town | 2-2 | | | | | |
