| Sat 30/07/22 | Prestwich Heys v Burscough * | 3-0 | | | | | |
| Tue 02/08/22 | West Didsbury & Chorlton v Prestwich Heys | 2-1 | | | | | |
| Sat 06/08/22 | Prestwich Heys v Litherland REMYCA | 1-1 | | |  | | |
| Sat 13/08/22 | Prestwich Heys v Charnock Richard * | 4-1 | | | | | |
| Wed 17/08/22 | Bury AFC v Prestwich Heys * | 0-2 | | | | | |
| Sat 20/08/22 | Prestwich Heys v Stocksbridge Park Steels * | 2-2 | | | | | |
| Tue 23/08/22 | Stocksbridge Park Steels v Prestwich Heys | 1-1 |  | | | | |
| Mon 29/08/22 | Barnoldswick Town v Prestwich Heys | 3-5 | | | | | |
| Sat 03/09/22 | Prestwich Heys v AFC Liverpool * | 0-2 | | | | | |
| Tue 06/09/22 | Kendal Town v Prestwich Heys | 2-1 | | | | | |
| Sat 17/09/22 | FC Isle of Man v Prestwich Heys | 0-3 | | | | | |
| Tue 20/09/22 | Prestwich Heys v Squires Gate | 3-1 | | | | | |
| Sat 24/09/22 | Prestwich Heys v Ashton Athletic | 1-0 | | | | | |
| Tue 27/09/22 | Prestwich Heys v Winsford United * | 0-1 | | | | | |
| Sat 22/10/22 | Winterton Rangers v Prestwich Heys * | 1-2 | | | | | |
| Tue 25/10/22 | Congleton Town v Prestwich Heys * | 1-0 | | | | | |
| Sat 29/10/22 | Wythenshawe Town v Prestwich Heys * | 3-1 | | | | | |
| Sat 05/11/22 | Prestwich Heys v Irlam * | 0-0 | | | | | |
| Sat 19/11/22 | Prestwich Heys v Litherland REMYCA * | 1-0 | | | | | |
| Tue 22/11/22 | Longridge Town v Prestwich Heys * | 2-1 | | | | | |
| Sat 26/11/22 | Burscough v Prestwich Heys | 3-1 | | | | | |
| Sat 03/12/22 | Prestwich Heys v Northwich Victoria * | 2-2 | | | | | |
| Tue 20/12/22 | Prestwich Heys v Longridge Town | - | | | | | |
| Mon 26/12/22 | Prestwich Heys v Lower Breck | 1-0 | | | | |  |
| Tue 24/01/23 | Prestwich Heys v Kendal Town * | 1-1 | | | | | |
| Tue 31/01/23 | Prestwich Heys v Longridge Town * | 2-0 | | | | | |
| Sat 04/02/23 | Prestwich Heys v Vauxhall Motors * | 1-0 | | | | | |
