| Sat 06/11/21 | Northwich Victoria v Ashton Athletic * | 7-1 | | | | | |
| Wed 10/11/21 | Barnoldswick Town v Northwich Victoria * | 1-4 | | | | | |
| Sat 13/11/21 | Lower Breck v Northwich Victoria * | 5-1 | | | | | |
| Sat 20/11/21 | Vauxhall Motors v Northwich Victoria | 1-2 | | | | | |
| Sat 27/11/21 | Northwich Victoria v Macclesfield | 3-4 | | | | |  |
| Tue 30/11/21 | Winsford United v Northwich Victoria | 3-0 | | |  | | |
| Sat 04/12/21 | Northwich Victoria v Charnock Richard | 0-2 | | | | | |
| Sat 18/12/21 | Northwich Victoria v Lower Breck | 7-0 |  | | | | |
| Mon 27/12/21 | Avro v Northwich Victoria | 2-1 | | | | | |
| Sun 16/01/22 | Northwich Victoria v Squires Gate | 2-1 | | | | | |
| Sat 22/01/22 | Northwich Victoria v Litherland REMYCA | 1-0 | | | | | |
| Tue 25/01/22 | Ashton Athletic v Northwich Victoria | 1-1 | | | | | |
| Sat 29/01/22 | Padiham v Northwich Victoria | 3-1 | | | | | |
| Sat 05/02/22 | Northwich Victoria v Congleton Town * | 2-1 | | | | | |
| Tue 08/02/22 | AFC Liverpool v Northwich Victoria * | 1-2 | | | | | |
| Sat 12/02/22 | Skelmersdale United v Northwich Victoria * | 2-0 | | | | | |
| Sat 26/02/22 | Northwich Victoria v Prestwich Heys | 0-1 | | | | | |
| Sat 05/03/22 | Northwich Victoria v Runcorn Town | 0-0 | | | | | |
| Sun 13/03/22 | Northwich Victoria v Winsford United * | 0-2 | | | | | |
| Wed 16/03/22 | Northwich Victoria v Macclesfield | 1-2 | | | | | |
| Sat 19/03/22 | Northwich Victoria v Burscough | 2-0 | | | | | |
| Sat 26/03/22 | Irlam v Northwich Victoria | 1-3 | | | | | |
| Tue 29/03/22 | Wythenshawe Town v Northwich Victoria | 1-2 | | | | | |
| Sat 02/04/22 | Northwich Victoria v Barnoldswick Town | 2-1 | | | | | |
