| Mon 08/08/22 | Maine Road v Cammell Laird 1907 * | 3-3 |  | | | | |
| Sat 13/08/22 | Cammell Laird 1907 v Stockport Town * | 0-3 | | | | | |
| Tue 16/08/22 | Cammell Laird 1907 v New Mills * | 3-2 | | | | | |
| Sat 20/08/22 | Barnton v Cammell Laird 1907 | 2-1 | | | | | |
| Sat 27/08/22 | Wythenshawe Amateurs v Cammell Laird 1907 | 1-1 | | | | | |
| Mon 29/08/22 | Stockport Georgians v Cammell Laird 1907 | 3-0 | | | | | |
| Sat 03/09/22 | Cammell Laird 1907 v Stafford Town * | 0-3 | | | | | |
| Tue 06/09/22 | Cammell Laird 1907 v Cheadle Heath Nomads | 3-3 | | | | | |
| Tue 13/09/22 | Cammell Laird 1907 v Ellesmere Rangers | 0-5 | | | |  | |
| Sat 17/09/22 | Cammell Laird 1907 v Brocton | 2-2 | | |  | | |
| Sat 15/10/22 | Cammell Laird 1907 v Ashville | 2-1 | | | | | |
| Sat 22/10/22 | Squires Gate v Cammell Laird 1907 | 2-1 | | | | | |
| Tue 25/10/22 | Abbey Hey v Cammell Laird 1907 | 1-0 | | | | | |
| Sat 29/10/22 | Stafford Town v Cammell Laird 1907 * | 1-2 | | | | | |
| Tue 08/11/22 | Cammell Laird 1907 v Wythenshawe Amateurs | 0-1 | | | | | |
| Sat 12/11/22 | Cammell Laird 1907 v Maine Road | 4-3 | | | | | |
| Sat 19/11/22 | Cammell Laird 1907 v South Liverpool * | 1-4 | | | | | |
| Tue 22/11/22 | Cammell Laird 1907 v Sutton Athletic | 2-0 | | | | | |
| Wed 30/11/22 | Cammell Laird 1907 v Abbey Hey * | 0-3 | | | | | |
| Tue 06/12/22 | Sandbach United v Cammell Laird 1907 * | 3-2 | | | | | |
| Sat 28/01/23 | Rocester v Cammell Laird 1907 | 2-3 | | | | | |
| Tue 31/01/23 | Foley Meir v Cammell Laird 1907 | 2-2 | | | | | |
| Sat 04/02/23 | Cammell Laird 1907 v Stockport Georgians | 1-3 | | | | | |
| Tue 07/02/23 | Abbey Hulton United v Cammell Laird 1907 * | 2-1 | | | | | |
| Tue 14/02/23 | Cammell Laird 1907 v Higher Bebington Kelma | 1-1 | | | | | |
| Sat 18/02/23 | Stockport Town v Cammell Laird 1907 | 5-0 | | | | | |
| Sat 25/02/23 | Cammell Laird 1907 v Rocester * | 2-1 | | | | | |
| Tue 28/02/23 | Cammell Laird 1907 v Sandbach United * | 2-3 | | | | | |
| Sat 04/03/23 | Capenhurst Villa v Cammell Laird 1907 * | 2-0 | | | | | |
| Sat 11/03/23 | Cammell Laird 1907 v Eccleshall | 2-2 | | | | | |
| Tue 14/03/23 | Brocton v Cammell Laird 1907 | 2-3 | | | | | |
| Sat 18/03/23 | Cheadle Heath Nomads v Cammell Laird 1907 | 3-0 | | | | | |
| Sat 25/03/23 | Cammell Laird 1907 v Abbey Hulton United | 2-2 | | | | | |
| Sat 01/04/23 | New Mills v Cammell Laird 1907 | 1-0 | | | | | |
| Sat 08/04/23 | Ashville v Cammell Laird 1907 | 3-0 | | | | | |
| Sat 15/04/23 | Ellesmere Rangers v Cammell Laird 1907 | 4-2 | | | | |  |
