| Sat 11/09/21 | Sandbach United v Stockport Town | 2-1 | | |  | | |
| Sat 18/09/21 | Sandbach United v Cammell Laird 1907 | 3-3 | | | | | |
| Sat 25/09/21 | Sandbach United v Dudley Town | 2-2 | | | | | |
| Sat 02/10/21 | West Didsbury & Chorlton v Sandbach United | 2-1 | | | | | |
| Sat 09/10/21 | Stafford Town v Sandbach United | 4-2 | | | | | |
| Sat 16/10/21 | Sandbach United v Wythenshawe Amateurs | 2-1 | | | | | |
| Tue 19/10/21 | Cheadle Heath Nomads v Sandbach United | 3-5 | | | | | |
| Sat 23/10/21 | Eynesbury Rovers v Sandbach United * | 1-2 | | | | | |
| Sat 30/10/21 | Cheadle Town v Sandbach United | 1-1 | | | | | |
| Sat 06/11/21 | Sandbach United v Barnton | 1-1 | | | | | |
| Tue 09/11/21 | Sandbach United v FC Isle of Man | 2-4 | | | | | |
| Sat 13/11/21 | New Mills v Sandbach United | 4-0 | | | | | |
| Tue 16/11/21 | Crewe Alexandra v Sandbach United | 2-1 | | | | | |
| Sat 20/11/21 | Sandbach United v Hanley Town | 1-0 | | | | | |
| Tue 23/11/21 | Sandbach United v Rocester | 4-3 | | | | | |
| Sat 27/11/21 | Wythenshawe Amateurs v Sandbach United | 1-0 | | | | | |
| Sat 04/12/21 | Sandbach United v West Didsbury & Chorlton | 1-1 | | | | | |
| Sat 11/12/21 | Loughborough University v Sandbach United | 4-0 | | | | | |
| Sat 18/12/21 | FC Isle of Man v Sandbach United | 3-5 |  | | | | |
| Mon 27/12/21 | Barnton v Sandbach United | 2-2 | | | | | |
| Sat 15/01/22 | Sandbach United v New Mills | 0-3 | | | | | |
| Sat 22/01/22 | Abbey Hey v Sandbach United | 2-2 | | | | | |
| Sat 29/01/22 | Stockport Town v Sandbach United | 3-1 | | | | | |
| Sat 05/02/22 | Sandbach United v Ellesmere Rangers | 4-1 | | | | | |
| Tue 08/02/22 | Sandbach United v Maine Road | 1-2 | | | | | |
| Sat 12/02/22 | Brocton v Sandbach United | 3-1 | | | | | |
| Sat 26/02/22 | Sandbach United v Cheadle Heath Nomads | 1-3 | | | | | |
| Sat 05/03/22 | St Martins v Sandbach United | 0-8 | | | | | |
| Tue 22/03/22 | Sandbach United v Cheadle Town | 2-1 | | | | | |
| Sat 26/03/22 | Sandbach United v Abbey Hulton United | 6-0 | | | | | |
| Tue 29/03/22 | Macclesfield v Sandbach United | 2-1 | | | | | |
| Sat 02/04/22 | Eccleshall v Sandbach United | 0-0 | | | | | |
| Tue 05/04/22 | Ellesmere Rangers v Sandbach United | 2-3 | | | | | |
| Mon 18/04/22 | Sandbach United v FC Isle of Man | 1-2 | | | | | |
