| Sat 02/08/25 | Maghull v Droylsden * | 4-3 | | | | | | |
| Sat 09/08/25 | Garstang v Droylsden | 2-1 | | | |  | | |
| Sat 16/08/25 | Droylsden v Squires Gate | 2-0 | |  | | | | |
| Fri 22/08/25 | Daisy Hill v Droylsden | 2-3 | | | | | | |
| Sat 30/08/25 | Ashton Athletic v Droylsden * | 1-4 |  | | | | | |
| Sat 06/09/25 | Droylsden v Colne | 2-1 | | | | | | |
| Sat 13/09/25 | Droylsden v Bacup Borough * | 6-1 | | | | | | |
| Sat 20/09/25 | Nostell Miners Welfare v Droylsden (CUP) | 0-4 | | | | | | |
| Fri 26/09/25 | Droylsden v Maine Road (CUP) | 1-2 | | | | | | |
| Sat 18/10/25 | Penistone Church v Droylsden (CUP) | 1-2 | | | | | | |
| Sat 25/10/25 | Droylsden v Steeton * | 1-3 | | | | | | |
| Tue 28/10/25 | Droylsden v AFC Blackpool (CUP) | 1-3 | | | | | | |
| Sat 01/11/25 | Fulwood Amateurs v Droylsden * | 4-3 | | | | | | |
| Sat 08/11/25 | Droylsden v Northwich Victoria (CUP) * | 4-2 | | | | | | |
| Sat 17/01/26 | Droylsden v Sherwood Colliery (CUP) * | 2-1 | | | | | | |
| Tue 20/01/26 | Ashton Town v Droylsden * | 0-0 | | | | | | |
| Fri 23/01/26 | Droylsden v Daisy Hill * | 2-0 | | | | | | |
| Sat 31/01/26 | MSB Woolton v Droylsden * | 4-1 | | | | | | |
| Tue 03/02/26 | Droylsden v Nelson | 3-0 | | | | | | |
| Sat 07/02/26 | Bilston Town v Droylsden (CUP) | 0-2 | | | | | | |
| Sat 14/02/26 | Steeton v Droylsden | 1-6 | | | | | | |
| Wed 18/02/26 | AFC Blackpool v Droylsden * | 0-2 | | | | | | |
| Sat 28/02/26 | Droylsden v Cockfosters FC (CUP) * | 2-4 | | | | | | |
| Tue 03/03/26 | Droylsden v West Didsbury & Chorlton (CUP) | 4-0 | | | | | | |
| Sat 07/03/26 | Bacup Borough v Droylsden | 1-2 | | | | | | |
| Tue 17/03/26 | Droylsden v Maghull * | 2-1 | | | | | | |
| Sat 21/03/26 | Droylsden v Ashton Athletic * | 3-1 | | | | | | |
| Tue 24/03/26 | Ashton United v Droylsden (CUP) | 2-3 | | | | | | |
