| Wed 03/08/22 | Litherland REMYCA v FC Isle of Man | 1-2 | | | | | |
| Sat 13/08/22 | FC Isle of Man v Ashton Athletic | 2-1 | | | | | |
| Sat 20/08/22 | Vauxhall Motors v FC Isle of Man | 2-1 | | | | | |
| Tue 23/08/22 | Padiham v FC Isle of Man | 0-1 | | | | | |
| Sat 27/08/22 | Congleton Town v FC Isle of Man | 5-1 | | | | | |
| Mon 29/08/22 | AFC Liverpool v FC Isle of Man | 5-2 | | | | | |
| Sat 03/09/22 | FC Isle of Man v Barnoldswick Town | 3-3 | | | | | |
| Tue 13/09/22 | Bury AFC v FC Isle of Man | 4-0 | | | | | |
| Sat 17/09/22 | FC Isle of Man v Prestwich Heys | 0-3 | | |  | | |
| Tue 20/09/22 | Irlam v FC Isle of Man | 3-1 | | | | | |
| Sat 24/09/22 | FC Isle of Man v Lower Breck | 3-1 | | | | | |
| Sat 01/10/22 | Charnock Richard v FC Isle of Man | 5-1 | | | | | |
| Tue 04/10/22 | Burscough v FC Isle of Man | 4-7 | | | | | |
| Sat 08/10/22 | FC Isle of Man v Padiham | 0-1 | | | | |  |
| Tue 11/10/22 | West Didsbury & Chorlton v FC Isle of Man | 2-1 | | | | | |
| Sun 16/10/22 | AFC Liverpool v FC Isle of Man | 1-0 | | | | | |
| Sat 22/10/22 | Billingham Town v FC Isle of Man | 1-4 | | | | | |
| Tue 25/10/22 | Wythenshawe Town v FC Isle of Man | 2-2 | | | | | |
| Sat 29/10/22 | FC Isle of Man v Congleton Town | 3-2 | | | | | |
| Sat 05/11/22 | FC Isle of Man v Northwich Victoria | 1-3 | | | | | |
| Sat 19/11/22 | Winsford United v FC Isle of Man | 3-0 | | | | | |
| Sat 26/11/22 | FC Isle of Man v Charnock Richard | 2-1 | | | | | |
| Sat 03/12/22 | Barnoldswick Town v FC Isle of Man | 0-1 | | | | | |
| Wed 28/12/22 | Avro v FC Isle of Man | 0-1 | | | | | |
| Mon 02/01/23 | FC Isle of Man v Burscough | 3-4 | | | | | |
| Sat 07/01/23 | FC Isle of Man v Kendal Town | 1-3 | | | | | |
| Sat 21/01/23 | FC Isle of Man v Vauxhall Motors | 0-3 | | | | | |
| Sat 28/01/23 | FC Isle of Man v Squires Gate | 1-4 | | | | | |
| Sat 04/02/23 | Kendal Town v FC Isle of Man | 3-2 | | | | | |
| Wed 08/02/23 | Squires Gate v FC Isle of Man | 3-2 | | | | | |
| Sat 11/02/23 | FC Isle of Man v Irlam | 4-1 | | | | | |
| Sat 18/02/23 | Ashton Athletic v FC Isle of Man | 0-1 | | | | | |
| Sat 25/02/23 | Prestwich Heys v FC Isle of Man | 1-0 | | | | | |
| Sat 04/03/23 | FC Isle of Man v Winsford United | 1-0 | | | | | |
| Sun 12/03/23 | Northwich Victoria v FC Isle of Man | 1-1 | | | | | |
| Sat 18/03/23 | FC Isle of Man v Longridge Town | 3-5 | | | | | |
