| Sat 26/07/25 | FC Isle of Man v Litherland REMYCA | 0-0 | |  | | | | |
| Tue 29/07/25 | FC St Helens v FC Isle of Man | 2-0 | | | | | | |
| Sat 09/08/25 | FC Isle of Man v Glossop North End | 2-3 | | | | | | |
| Tue 12/08/25 | Irlam v FC Isle of Man | 4-0 | | | | | | |
| Sat 16/08/25 | Abbey Hey v FC Isle of Man | 1-2 | | | | | | |
| Mon 25/08/25 | Wythenshawe v FC Isle of Man | 4-0 | | | | | | |
| Sat 30/08/25 | FC Isle of Man v Padiham | 2-3 | | | | | | |
| Sat 13/09/25 | FC Isle of Man v Charnock Richard | 3-2 | | | |  | | |
| Sat 20/09/25 | Pilkington v FC Isle of Man | 0-0 | | | | | | |
| Sat 04/10/25 | FC Isle of Man v Barnoldswick Town | 1-2 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man | 1-3 | | | | | | |
| Sat 18/10/25 | FC Isle of Man v FC St Helens | 2-2 | | | | | | |
| Sat 01/11/25 | FC Isle of Man v Longridge Town * | 2-2 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton | 1-3 | | | | | |  |
| Sat 22/11/25 | Longridge Town v FC Isle of Man | 2-5 | | | | | | |
| Sat 29/11/25 | Prestwich Heys v FC Isle of Man | 5-0 | | | | | | |
| Sat 13/12/25 | FC Isle of Man v AFC Liverpool | 5-0 | | | | | | |
| Sat 20/12/25 | Glossop North End v FC Isle of Man | 2-3 |  | | | | | |
| Sat 27/12/25 | FC Isle of Man v Stockport Town | 0-4 | | | | | | |
| Sat 10/01/26 | FC Isle of Man v Burscough | 0-1 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man | 3-2 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool | 3-2 | | | | | | |
| Wed 28/01/26 | Atherton LR v FC Isle of Man | 3-1 | | | | | | |
| Sat 31/01/26 | FC Isle of Man v Ramsbottom United | 4-4 | | | | | | |
| Sat 07/02/26 | FC Isle of Man v Euxton Villa | 1-0 | | | | | | |
| Sat 21/02/26 | FC Isle of Man v Wythenshawe | 2-1 | | | | | | |
| Sat 28/02/26 | FC Isle of Man v Abbey Hey | 2-2 | | | | |  | |
| Sat 21/03/26 | FC Isle of Man v Cheadle Town | 1-2 | | | | | | |
| Sat 28/03/26 | FC Isle of Man v City of Liverpool | 3-1 | | | | | | |
