| Sat 31/07/21 | Longridge Town v Congleton Town | 0-1 | | | | | |
| Tue 03/08/21 | Irlam v Congleton Town | 0-3 | | | | | |
| Sun 08/08/21 | Emley AFC v Congleton Town | 3-2 | | | | | |
| Tue 17/08/21 | Congleton Town v Northwich Victoria | 3-1 | | | | | |
| Sat 21/08/21 | Litherland REMYCA v Congleton Town | 1-5 |  | | | | |
| Sat 28/08/21 | Congleton Town v Ashton Athletic | 1-2 | | | | | |
| Mon 30/08/21 | Macclesfield v Congleton Town | 1-0 | | | | | |
| Sat 11/09/21 | Vauxhall Motors v Congleton Town | 0-1 | | | | | |
| Tue 14/09/21 | Congleton Town v Avro | 1-2 | | | | | |
| Sat 18/09/21 | Padiham v Congleton Town * | 3-3 | |  | | | |
| Tue 21/09/21 | Prestwich Heys v Congleton Town | 1-0 | | | | | |
| Tue 28/09/21 | Wythenshawe Town v Congleton Town | 0-1 | | |  | | |
| Sat 02/10/21 | Congleton Town v AFC Liverpool | 6-1 | | | | | |
| Tue 05/10/21 | Congleton Town v Squires Gate | 0-0 | | | | |  |
| Sat 09/10/21 | Barnoldswick Town v Congleton Town | 2-2 | | | | | |
| Tue 26/10/21 | Congleton Town v Stalybridge Celtic | 0-3 | | | | | |
| Sat 30/10/21 | Congleton Town v Winsford United | 0-3 | | | | | |
| Tue 09/11/21 | Congleton Town v Skelmersdale United * | 1-3 | | | | | |
| Sat 20/11/21 | Boldmere St Michaels v Congleton Town | 1-1 | | | | | |
| Wed 24/11/21 | Avro v Congleton Town | 1-1 | | | | | |
| Sat 27/11/21 | Congleton Town v Prestwich Heys | 2-0 | | | | | |
| Sat 04/12/21 | Squires Gate v Congleton Town | 0-1 | | | | | |
| Sat 11/12/21 | Highgate United v Congleton Town | 0-4 | | | | | |
| Sat 18/12/21 | Congleton Town v Runcorn Town | 4-1 | | | | | |
| Tue 21/12/21 | Burscough v Congleton Town | 2-1 | | | | | |
| Mon 27/12/21 | Congleton Town v Vauxhall Motors | 0-2 | | | | | |
| Sat 15/01/22 | Whitchurch Alport v Congleton Town | 2-1 | | | | | |
| Sat 22/01/22 | Skelmersdale United v Congleton Town | 3-2 | | | | | |
| Tue 25/01/22 | Congleton Town v Charnock Richard | 2-3 | | | | | |
| Sat 29/01/22 | Ashton Athletic v Congleton Town | 0-1 | | | | | |
| Sat 05/02/22 | Northwich Victoria v Congleton Town | 2-1 | | | | | |
| Tue 08/02/22 | Congleton Town v Barnoldswick Town | 2-2 | | | | | |
| Sat 12/02/22 | AFC Liverpool v Congleton Town | 0-0 | | | | | |
| Sat 19/02/22 | Lower Breck v Congleton Town | 2-2 | | | | | |
| Tue 01/03/22 | Congleton Town v Wythenshawe Town | 1-1 | | | | | |
| Thu 17/03/22 | Congleton Town v Rocester * | 5-0 | | | | | |
| Sat 19/03/22 | Winsford United v Congleton Town * | 0-2 | | | | | |
| Sat 26/03/22 | Congleton Town v Macclesfield | 1-3 | | | | | |
| Sat 30/04/22 | Congleton Town v Bacup Borough * | 1-0 | | | | | |
