| Sat 30/07/22 | Ashton Athletic v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 02/08/22 | West Didsbury & Chorlton v Prestwich Heys | 2-1 | | | | | |
| Sat 06/08/22 | Longridge Town v West Didsbury & Chorlton | 0-1 | | | | | |
| Tue 09/08/22 | Congleton Town v West Didsbury & Chorlton | 1-1 | | | | | |
| Wed 14/09/22 | Northwich Victoria v West Didsbury & Chorlton | 2-1 | | | | | |
| Tue 27/09/22 | Burscough v West Didsbury & Chorlton | 1-6 | | | | |  |
| Sat 01/10/22 | Padiham v West Didsbury & Chorlton | 2-3 | | | | | |
| Tue 04/10/22 | West Didsbury & Chorlton v Lower Breck | 1-4 | | | | | |
| Sat 08/10/22 | West Didsbury & Chorlton v Congleton Town | 3-2 |  | |  | | |
| Tue 11/10/22 | West Didsbury & Chorlton v FC Isle of Man | 2-1 | | | | | |
| Sat 15/10/22 | Pilkington v West Didsbury & Chorlton | 3-0 | | | | | |
| Sat 22/10/22 | West Didsbury & Chorlton v Golcar United | 2-1 | | | | | |
| Tue 25/10/22 | West Didsbury & Chorlton v Bury AFC | 0-3 | | | | | |
| Sat 12/11/22 | Bacup Borough v West Didsbury & Chorlton | 2-2 | | | | | |
| Sat 19/11/22 | West Didsbury & Chorlton v Padiham | 3-0 | | | | | |
| Sat 26/11/22 | West Didsbury & Chorlton v Squires Gate | 1-1 | | | | | |
| Sat 03/12/22 | Whitley Bay v West Didsbury & Chorlton | 1-1 | | | | | |
| Sat 07/01/23 | AFC Liverpool v West Didsbury & Chorlton | 5-3 | | | | | |
| Sat 14/01/23 | West Didsbury & Chorlton v Horden Community Welfare | 2-0 | | | | | |
| Sat 28/01/23 | Irlam v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 31/01/23 | Wythenshawe Town v West Didsbury & Chorlton | 0-3 | | | | | |
| Sat 04/02/23 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | |
| Tue 14/02/23 | West Didsbury & Chorlton v Northwich Victoria | 1-1 | | | | | |
| Sat 18/02/23 | West Didsbury & Chorlton v AFC Liverpool | 3-0 | | | | | |
| Tue 21/02/23 | Bury AFC v West Didsbury & Chorlton | 0-0 | | | | | |
| Sat 11/03/23 | West Didsbury & Chorlton v Ascot United | 1-1 | | | | | |
| Sat 18/03/23 | West Didsbury & Chorlton v Winsford United | 1-1 | | | | | |
| Thu 06/04/23 | Prestwich Heys v West Didsbury & Chorlton | 2-1 | | | | | |
| Mon 10/04/23 | Charnock Richard v West Didsbury & Chorlton | 5-1 | |  | |  | |
| Thu 13/04/23 | Lower Breck v West Didsbury & Chorlton | 1-1 | | | | | |
| Sat 15/04/23 | West Didsbury & Chorlton v Longridge Town | 2-2 | | | | | |
