| 21/08/21 | Irlam 1-5 Skelmersdale Utd |
| 28/08/21 | Irlam 2-2 Runcorn Town
1 goal |
| 30/08/21 | Winsford United 1-7 Irlam |
| 07/09/21 | Irlam 2-0 Wythenshawe Town
MoM |
| 11/09/21 | Cheadle Town 0-1 Irlam |
| 14/09/21 | Padiham 0-1 Irlam |
| 18/09/21 | Longridge Town 1-3 Irlam
1 goal |
| 21/09/21 | Irlam 0-3 Barnoldswick Town |
| 25/09/21 | Burscough 2-0 Irlam |
| 28/09/21 | Irlam 1-0 Skelmersdale Utd |
| 02/10/21 | Burscough 3-4 Irlam |
| 05/10/21 | Prestwich Heys 0-2 Irlam |
| 09/10/21 | Northwich Vics 2-1 Irlam |
| 12/10/21 | Squires Gate 2-5 Irlam
1 goal |
| 23/10/21 | Irlam 1-4 Lower Breck * |
| 30/10/21 | Ashton Athletic 2-0 Irlam |
| 06/11/21 | Irlam 0-1 Charnock Richard |
| 13/11/21 | Irlam 0-4 AFC Liverpool |
| 20/11/21 | Lower Breck 4-0 Irlam
Yellow Card |
| 27/11/21 | Irlam 3-0 Winsford United |
| 17/12/21 | Irlam 0-1 Padiham |
| 27/12/21 | Wythenshawe Town 1-0 Irlam |
| 11/01/22 | Irlam 1-4 Prestwich Heys |
| 15/01/22 | Barnoldswick Town 2-2 Irlam
1 goal , MoM |
| 22/01/22 | Irlam 2-1 Burscough |
| 28/01/22 | Litherland REMY 2-3 Irlam
1 goal |
| 01/02/22 | Runcorn Town 1-2 Irlam
1 goal |
| 05/02/22 | Vauxhall Mtrs 1-2 Irlam
1 goal |
| 08/02/22 | Irlam 2-2 Macclesfield
Yellow Card |
| 12/02/22 | Irlam 2-1 Avro |
| 26/02/22 | Skelmersdale Utd 2-0 Irlam |
| 05/03/22 | Congleton Town 1-1 Irlam |
| 12/03/22 | Irlam 0-2 Squires Gate |
| 15/03/22 | Irlam 3-1 Longridge Town *
1 goal |
| 19/03/22 | AFC Liverpool 0-2 Irlam |
| 22/03/22 | Charnock Richard 2-1 Irlam
1 goal |
| 26/03/22 | Irlam 1-3 Northwich Vics |
| 30/03/22 | Barnton 2-1 Irlam |
| 02/04/22 | Irlam 1-1 Ashton Athletic |
