| Fri 08/08/25 | Prestwich Heys v Burscough * | 0-2 | |  | | | | |
| Sat 08/11/25 | Burscough v Ashton Town (CUP) * | 3-1 | | | | | | |
| Sat 15/11/25 | Burscough v Glossop North End * | 1-2 | | | | | | |
| Sat 22/11/25 | Burscough v AFC Blackpool (CUP) * | 3-1 | | | | | | |
| Sat 06/12/25 | Chadderton v Burscough (CUP) * | 0-0 | | | | | | |
| Tue 09/12/25 | Marine v Burscough (CUP) | 3-3 |  | | | | | |
| Sat 13/12/25 | Charnock Richard v Burscough | 2-1 | | | | | | |
| Sat 20/12/25 | Burscough v Irlam * | 3-0 | | | | | | |
| Fri 26/12/25 | Atherton LR v Burscough * | 1-0 | | | | | | |
| Sat 03/01/26 | Pilkington v Burscough | 2-6 | | | | | | |
| Sat 10/01/26 | FC Isle of Man v Burscough | 0-1 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool | 5-2 | | | | | | |
| Sat 17/01/26 | Cheadle Town v Burscough | 0-0 | | | | | | |
| Tue 20/01/26 | Burscough v Charnock Richard * | 3-1 | | | | | | |
| Sat 24/01/26 | Burscough v Prestwich Heys * | 1-1 | | | | | | |
| Tue 27/01/26 | City of Liverpool v Burscough | 1-7 | | | | | | |
| Sat 31/01/26 | Burscough v West Didsbury & Chorlton | 1-0 | | | | | | |
| Sat 14/02/26 | Burscough v Cheadle Town (CUP) * | 4-0 | | | | | | |
| Tue 17/02/26 | Wythenshawe v Burscough * | 3-1 | | | | | | |
| Sat 21/02/26 | Burscough v Chadderton | 0-3 | | | | | | |
| Fri 27/02/26 | FC St Helens v Burscough * | 1-0 | | | | | | |
| Sat 07/03/26 | Burscough v Ramsbottom United * | 1-0 | | | | | | |
| Sat 14/03/26 | Burscough v Stockport Town * | 0-3 | | | | | | |
| Sat 28/03/26 | Burscough v Barnoldswick Town * | 4-2 | | | | | | |
| Sat 04/04/26 | Burscough v West Didsbury & Chorlton (CUP) * | 0-0 | | | | | | |
| Mon 06/04/26 | Burscough v Atherton LR * | 0-2 | | | | | | |
| Tue 14/04/26 | Longridge Town v Burscough | 4-2 | | | | | | |
| Sat 18/04/26 | Litherland REMYCA v Burscough | 1-2 | | | | | | |
