| 04/08/21 | Cheadle Town 2-0 Abbey Hey
Yellow Card |
| 07/08/21 | Rocester 1-2 Cheadle Town |
| 14/08/21 | St Martins 1-5 Cheadle Town
2 goals |
| 21/08/21 | Cheadle Town 0-2 Wythenshawe Am |
| 30/08/21 | Cheadle Heath 3-2 Cheadle Town *
1 goal |
| 06/09/21 | Maine Road 0-2 Cheadle Town
Yellow Card |
| 02/10/21 | Abbey Hulton Utd 3-2 Cheadle Town
Red Card |
| 27/10/21 | Cheadle Town 2-1 FC Isle of Man
Yellow Card |
| 06/11/21 | Cheadle Town 7-1 Ellesmere Rngrs |
| 09/11/21 | West Didsbury 1-0 Cheadle Town |
| 13/11/21 | Eccleshall 3-2 Cheadle Town |
| 20/11/21 | Cheadle Town 3-0 Rocester
Yellow Card |
| 23/11/21 | Abbey Hey 2-2 Cheadle Town |
| 27/11/21 | Cheadle Town 3-3 Abbey Hulton Utd |
| 27/12/21 | Cheadle Town 0-0 Cheadle Heath |
| 04/01/22 | Cammell Laird 1-4 Cheadle Town |
| 15/01/22 | Cheadle Town 3-3 Maine Road |
| 22/01/22 | FC Isle of Man 5-2 Cheadle Town |
| 29/01/22 | Ellesmere Rngrs 1-8 Cheadle Town
2 goals |
| 05/02/22 | Cheadle Town 3-1 Alsager Town
1 goal |
| 12/02/22 | Cheadle Town 5-0 St Martins |
| 05/03/22 | Barnton 0-2 Cheadle Town
1 goal , Yellow Card |
| 09/03/22 | Cheadle Town 0-2 FC Isle of Man
Red Card |
| 12/03/22 | Cheadle Town 1-1 Eccleshall |
| 29/03/22 | New Mills 3-0 Cheadle Town |
| 02/04/22 | Cheadle Town 0-1 West Didsbury |
