| Sat 01/10/22 | South Liverpool v Ilkley Town | 0-4 | | |  | | |
| Tue 04/10/22 | FC St Helens v South Liverpool | 2-1 |  | | | | |
| Sat 08/10/22 | South Liverpool v Holker Old Boys | 1-1 | | | | | |
| Sat 15/10/22 | Vauxhall Motors v South Liverpool | 1-1 | | | | | |
| Sat 22/10/22 | Nelson v South Liverpool | 1-4 | | | | | |
| Sat 29/10/22 | South Liverpool v Holker Old Boys | 1-2 | | | | | |
| Wed 02/11/22 | South Liverpool v Skelmersdale United | 3-3 | | | | | |
| Sat 05/11/22 | South Liverpool v AFC Blackpool | 5-1 | | | | | |
| Sat 12/11/22 | Atherton LR v South Liverpool | 1-3 | | | | | |
| Sat 19/11/22 | Cammell Laird 1907 v South Liverpool | 1-4 | | | | | |
| Wed 23/11/22 | South Liverpool v Atherton LR | 2-3 | | | | | |
| Sat 26/11/22 | South Liverpool v AFC Blackpool | 2-2 | | | | | |
| Wed 30/11/22 | South Liverpool v Litherland REMYCA | 2-3 | | | | | |
| Fri 02/12/22 | South Liverpool v Ashton Town | 2-1 | | | | | |
| Wed 07/12/22 | Darwen FC v South Liverpool | 2-2 | | | | | |
| Wed 28/12/22 | South Liverpool v Runcorn Town | 5-0 | | | | | |
| Sat 07/01/23 | South Liverpool v Darwen FC | 1-4 | | | | | |
| Tue 17/01/23 | Steeton v South Liverpool | 1-1 | | | | | |
| Sat 21/01/23 | South Liverpool v Abbey Hulton United | 4-1 | | | | | |
| Sat 28/01/23 | South Liverpool v Nelson | 2-1 | | | | | |
| Fri 10/02/23 | South Liverpool v Pilkington * | 1-2 | | | | | |
| Sat 18/02/23 | South Liverpool v Bacup Borough | 2-4 | | | | | |
| Sat 25/02/23 | South Liverpool v Abbey Hulton United | 1-1 | | | | | |
| Wed 01/03/23 | South Liverpool v Bacup Borough | 4-1 | | | | | |
| Sat 18/03/23 | South Liverpool v Garstang | 4-2 | | | | | |
