| Sat 27/07/24 | FC St Helens v Abbey Hey * | 3-0 | |  | | | | |
| Wed 31/07/24 | Cheadle Town v FC St Helens * | 1-3 | | | |  | | |
| Sun 04/08/24 | Emley v FC St Helens (CUP) * | 1-0 | | | | | | |
| Sat 10/08/24 | FC St Helens v Ramsbottom United | 0-3 | | | | | | |
| Tue 13/08/24 | FC St Helens v FC Isle of Man * | 5-4 | | | | | | |
| Sat 17/08/24 | FC St Helens v Lower Breck * | 1-1 | | | | | | |
| Sat 24/08/24 | FC St Helens v Cheadle Heath Nomads (CUP) * | 2-1 | | | | | | |
| Tue 27/08/24 | FC St Helens v Prestwich Heys | 4-2 | | | | | | |
| Sat 31/08/24 | FC St Helens v Stockport Town | 4-1 | | | | | | |
| Tue 03/09/24 | AFC Liverpool v FC St Helens | 1-2 | | | | | | |
| Sat 21/09/24 | Stockport Town v FC St Helens (CUP) | 2-1 | | | | | | |
| Tue 24/09/24 | FC St Helens v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 05/10/24 | FC St Helens v AFC Liverpool * | 3-2 | | | | | | |
| Tue 08/10/24 | FC St Helens v Litherland REMYCA (CUP) | 2-1 | | | | | | |
| Sat 12/10/24 | Prestwich Heys v FC St Helens * | 0-3 | | | | | | |
| Wed 16/10/24 | South Liverpool v FC St Helens | 1-1 | | | | | | |
| Tue 22/10/24 | Padiham v FC St Helens * | 3-3 | | | | | | |
| Sat 26/10/24 | West Didsbury & Chorlton v FC St Helens * | 3-1 | | | | | | |
| Tue 29/10/24 | FC St Helens v Irlam | 0-1 | | | | | | |
| Sat 16/11/24 | Squires Gate v FC St Helens | 2-3 | | | | | | |
| Tue 26/11/24 | FC St Helens v Lower Breck (CUP) | 1-2 | | | | | | |
| Sat 30/11/24 | FC St Helens v Colne * | 2-0 | | | | | | |
| Sat 14/12/24 | Burscough v FC St Helens | 1-0 | | | | | | |
| Tue 17/12/24 | Glossop North End v FC St Helens | 2-0 | | | | | | |
| Sat 21/12/24 | FC St Helens v Squires Gate | 5-0 | | | | | | |
| Thu 26/12/24 | FC St Helens v Pilkington | 2-1 | | | | | | |
| Fri 17/01/25 | Chadderton v FC St Helens | 3-0 | | | | | | |
| Sat 25/01/25 | Colne v FC St Helens | 2-1 | | | | | | |
| Sat 01/02/25 | FC St Helens v Charnock Richard | 4-1 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens | 0-1 | | | | | | |
| Tue 11/02/25 | Barnoldswick Town v FC St Helens * | 4-1 | | | | | | |
| Sat 15/02/25 | FC St Helens v Cheadle Town | 0-1 | | | | | | |
| Tue 18/02/25 | FC St Helens v Longridge Town | 3-0 | | | | | | |
| Sat 22/02/25 | FC St Helens v Padiham | 2-3 | | | | | | |
| Sat 08/03/25 | Lower Breck v FC St Helens * | 5-1 | | | | | | |
| Sat 15/03/25 | FC St Helens v Bury * | 0-1 | | | | | | |
| Sat 22/03/25 | Longridge Town v FC St Helens * | 0-4 | | | | | | |
| Sat 29/03/25 | Stockport Town v FC St Helens * | 3-1 | | | | | | |
| Sat 05/04/25 | FC St Helens v South Liverpool | 5-0 | | | | | | |
| Sat 12/04/25 | Abbey Hey v FC St Helens | 0-0 | | | | | | |
| Sat 19/04/25 | Irlam v FC St Helens | 0-3 | | | | | | |
