| Sat 27/07/24 | Pilkington v Ramsbottom United * | 2-2 |  | | | | | |
| Wed 07/08/24 | Pilkington v Wythenshawe (CUP) | 3-1 | | | | | | |
| Sat 10/08/24 | Charnock Richard v Pilkington | 4-2 | | | | | | |
| Wed 14/08/24 | Pilkington v West Didsbury & Chorlton | 1-1 | | | | | | |
| Sat 17/08/24 | Whitchurch Alport v Pilkington (CUP) * | 3-1 | | | | | | |
| Sat 14/09/24 | Padiham v Pilkington * | 2-0 | | | | | | |
| Wed 18/09/24 | Pilkington v Cheadle Town * | 1-3 | | | | | | |
| Sat 21/09/24 | Pilkington v Staveley Miners Welfare (CUP) | 2-3 | | | | | | |
| Tue 24/09/24 | Burscough v Pilkington | 3-2 | | | | | | |
| Sat 28/09/24 | Pilkington v Charnock Richard | 1-0 | |  | | | | |
| Wed 02/10/24 | Pilkington v Lower Breck (CUP) * | 1-2 | | | | | | |
| Wed 09/10/24 | South Liverpool v Pilkington | 0-0 | | | |  | | |
| Sat 12/10/24 | Colne v Pilkington | 2-4 | | | | | | |
| Sat 19/10/24 | Pilkington v Prestwich Heys | - | | | | | | |
| Sat 26/10/24 | Pilkington v AFC Liverpool | 1-2 | | | | | | |
| Sat 02/11/24 | Bury v Pilkington * | 2-0 | | | | | | |
| Sat 09/11/24 | Pilkington v Prestwich Heys * | 3-2 | | | | | | |
| Sat 16/11/24 | Ramsbottom United v Pilkington | 2-0 | | | | | | |
| Sat 23/11/24 | Pilkington v FC Isle of Man | 3-3 | | | | | | |
| Wed 27/11/24 | Pilkington v South Liverpool | 4-3 | | | | | | |
| Sat 30/11/24 | Pilkington v Abbey Hey | 4-1 | | | | | | |
| Tue 03/12/24 | Prescot Cables v Pilkington (CUP) * | 4-1 | | | | | | |
| Sat 18/01/25 | Pilkington v Stockport Town * | 0-3 | | | | | | |
| Thu 23/01/25 | Lower Breck v Pilkington | 5-0 | | | | | | |
| Sat 25/01/25 | Pilkington v Padiham | 1-3 | | | | | | |
| Sat 01/02/25 | AFC Liverpool v Pilkington | 2-0 | | | | | | |
| Sat 22/02/25 | West Didsbury & Chorlton v Pilkington * | 3-1 | | | | | | |
| Sat 01/03/25 | Pilkington v Barnoldswick Town | 2-0 | | | | | | |
| Sat 08/03/25 | Stockport Town v Pilkington | 2-1 | | | | | | |
| Sat 15/03/25 | FC Isle of Man v Pilkington | 3-3 | | | | | | |
| Sat 12/04/25 | Pilkington v Squires Gate * | 3-1 | | | | | | |
| Sat 19/04/25 | Glossop North End v Pilkington * | 4-0 | | | | | | |
