| Sat 30/08/25 | Glossop North End v South Liverpool * | 0-1 | |  | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton * | 0-1 | | | |  | | |
| Wed 10/09/25 | South Liverpool v FC St Helens | 1-2 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool | 3-0 | | | | | | |
| Wed 17/09/25 | South Liverpool v Abbey Hey | 5-3 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | | |
| Sat 27/09/25 | AFC Liverpool v South Liverpool (CUP) | 3-1 | | | | | | |
| Sat 11/10/25 | Longridge Town v South Liverpool | 1-1 | | | | | | |
| Wed 15/10/25 | South Liverpool v Euxton Villa | 1-1 | | | | | | |
| Sat 18/10/25 | Northallerton Town v South Liverpool (CUP) * | 1-2 | | | | | | |
| Sat 25/10/25 | South Liverpool v Atherton LR | 2-1 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 |  | | | | |  |
| Sat 01/11/25 | Abbey Hey v South Liverpool | 2-3 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard | 3-0 | | | | | | |
| Sat 08/11/25 | South Liverpool v Barton Town (CUP) | 4-0 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool | 3-1 | | | | | | |
| Sat 29/11/25 | South Liverpool v Chadderton | 2-3 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool | 3-1 | | | | | | |
| Sat 06/12/25 | Albion Sports v South Liverpool (CUP) | 0-3 | | | | | | |
| Wed 17/12/25 | South Liverpool v Cheadle Town * | 2-2 | | | | | | |
| Sat 20/12/25 | South Liverpool v Padiham | 1-0 | | | | | | |
| Sat 03/01/26 | South Liverpool v Wythenshawe | 1-3 | | | | |  | |
| Wed 28/01/26 | South Liverpool v Pilkington | 3-1 | | | | | | |
| Sat 31/01/26 | Cheadle Town v South Liverpool | 4-2 | | | | | | |
