| Sat 27/07/24 | FC St Helens v Abbey Hey | 3-0 | |  | | | |  |
| Wed 31/07/24 | Cheadle Town v FC St Helens | 1-3 | | | | | | |
| Sun 04/08/24 | Emley v FC St Helens (CUP) * | 1-0 | | | | | | |
| Sat 10/08/24 | FC St Helens v Ramsbottom United | 0-3 | | | | | | |
| Tue 13/08/24 | FC St Helens v FC Isle of Man | 5-4 |  | | |  | | |
| Sat 17/08/24 | FC St Helens v Lower Breck | 1-1 | | | | | | |
| Sat 07/09/24 | FC St Helens v Litherland REMYCA * | 2-1 | | | | | | |
| Sat 14/09/24 | Charnock Richard v FC St Helens | 2-2 | | | | | | |
| Tue 17/09/24 | FC St Helens v Burscough * | 2-2 | | | | | | |
| Sat 21/09/24 | Stockport Town v FC St Helens (CUP) | 2-1 | | | | | | |
| Tue 24/09/24 | FC St Helens v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 05/10/24 | FC St Helens v AFC Liverpool | 3-2 | | | | | | |
| Sat 12/10/24 | Prestwich Heys v FC St Helens * | 0-3 | | | | | | |
| Wed 16/10/24 | South Liverpool v FC St Helens | 1-1 | | | | | | |
| Tue 22/10/24 | Padiham v FC St Helens | 3-3 | | | | | | |
| Sat 26/10/24 | West Didsbury & Chorlton v FC St Helens | 3-1 | | | | | | |
| Tue 29/10/24 | FC St Helens v Irlam | 0-1 | | | | | | |
| Fri 01/11/24 | FC St Helens v Chadderton | 1-0 | | | | | | |
| Tue 05/11/24 | Bury v FC St Helens | 1-1 | | | | | | |
| Sat 09/11/24 | FC St Helens v Barnoldswick Town | 0-1 | | | | | | |
| Sat 16/11/24 | Squires Gate v FC St Helens | 2-3 | | | | | | |
| Tue 26/11/24 | FC St Helens v Lower Breck (CUP) | 1-2 | | | | | | |
| Sat 30/11/24 | FC St Helens v Colne | 2-0 | | | | | | |
| Sat 14/12/24 | Burscough v FC St Helens | 1-0 | | | | | | |
| Tue 17/12/24 | Glossop North End v FC St Helens | 2-0 | | | | | | |
| Sat 21/12/24 | FC St Helens v Squires Gate | 5-0 | | | | | | |
| Fri 17/01/25 | Chadderton v FC St Helens * | 3-0 | | | | | | |
| Sat 25/01/25 | Colne v FC St Helens | 2-1 | | | | | | |
| Sat 01/02/25 | FC St Helens v Charnock Richard | 4-1 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens | 0-1 | | | | | | |
| Tue 11/02/25 | Barnoldswick Town v FC St Helens * | 4-1 | | | | | | |
| Sat 15/02/25 | FC St Helens v Cheadle Town | 0-1 | | | | | | |
| Tue 18/02/25 | FC St Helens v Longridge Town | 3-0 | | | | | | |
| Sat 22/02/25 | FC St Helens v Padiham | 2-3 | | | | | | |
| Sat 08/03/25 | Lower Breck v FC St Helens * | 5-1 | | | | | | |
| Sat 15/03/25 | FC St Helens v Bury | 0-1 | | | | | | |
| Sat 22/03/25 | Longridge Town v FC St Helens | 0-4 | | | | | | |
