| Sat 27/07/24 | Pilkington v Ramsbottom United | 2-2 | | | | | | |
| Wed 31/07/24 | Litherland REMYCA v Pilkington | 0-1 | |  | | | | |
| Sat 03/08/24 | Wythenshawe v Pilkington (CUP) | 0-0 | | | |  | | |
| Wed 07/08/24 | Pilkington v Wythenshawe (CUP) * | 3-1 | | | | | | |
| Wed 14/08/24 | Pilkington v West Didsbury & Chorlton * | 1-1 | | | | | | |
| Sat 17/08/24 | Whitchurch Alport v Pilkington (CUP) | 3-1 | | | | | | |
| Wed 21/08/24 | Pilkington v Chadderton | 2-2 | | | | | | |
| Sat 24/08/24 | Barnoldswick Town v Pilkington | 2-0 | | | | | | |
| Mon 26/08/24 | Pilkington v Colne | 1-1 | | | | | | |
| Sat 07/09/24 | Pilkington v Lower Breck | 1-4 | | | | | | |
| Tue 10/09/24 | Abbey Hey v Pilkington | 4-3 | | | | | | |
| Sat 14/09/24 | Padiham v Pilkington | 2-0 | | | | | | |
| Wed 18/09/24 | Pilkington v Cheadle Town | 1-3 | | | | | | |
| Sat 21/09/24 | Pilkington v Staveley Miners Welfare (CUP) | 2-3 | | | | | | |
| Tue 24/09/24 | Burscough v Pilkington | 3-2 |  | | | | | |
| Sat 28/09/24 | Pilkington v Charnock Richard | 1-0 | | | | | | |
| Wed 02/10/24 | Pilkington v Lower Breck (CUP) * | 1-2 | | | | | | |
| Sat 05/10/24 | Pilkington v Irlam | 1-3 | | | | | | |
| Wed 09/10/24 | South Liverpool v Pilkington | 0-0 | | | | | | |
| Sat 12/10/24 | Colne v Pilkington | 2-4 | | | | | | |
| Sat 19/10/24 | Pilkington v Prestwich Heys | - | | | | | | |
| Sat 26/10/24 | Pilkington v AFC Liverpool | 1-2 | | | | | | |
| Sat 02/11/24 | Bury v Pilkington | 2-0 | | | | | | |
| Sat 09/11/24 | Pilkington v Prestwich Heys | 3-2 | | | | | | |
| Sat 23/11/24 | Pilkington v FC Isle of Man | 3-3 | | | | | | |
| Wed 27/11/24 | Pilkington v South Liverpool | 4-3 | | | | | | |
| Sat 30/11/24 | Pilkington v Abbey Hey | 4-1 | | | | | | |
| Tue 03/12/24 | Prescot Cables v Pilkington (CUP) | 4-1 | | | | | | |
| Sat 14/12/24 | Pilkington v Glossop North End | 1-3 | | | | | | |
| Sat 21/12/24 | Cheadle Town v Pilkington | 4-0 | | | | | |  |
| Sat 28/12/24 | Pilkington v Litherland REMYCA | 2-2 | | | | | | |
| Sat 04/01/25 | Pilkington v Burscough | 2-2 | | | | | | |
| Tue 07/01/25 | Squires Gate v Pilkington | 3-4 | | | | | | |
| Sat 18/01/25 | Pilkington v Stockport Town | 0-3 | | | | | | |
| Thu 23/01/25 | Lower Breck v Pilkington | 5-0 | | | | | | |
| Sat 25/01/25 | Pilkington v Padiham | 1-3 | | | | | | |
| Sat 01/02/25 | AFC Liverpool v Pilkington | 2-0 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens | 0-1 | | | | | | |
| Sat 15/02/25 | Prestwich Heys v Pilkington | 2-2 | | | | | | |
| Sat 22/02/25 | West Didsbury & Chorlton v Pilkington | 3-1 | | | | | | |
| Sat 01/03/25 | Pilkington v Barnoldswick Town | 2-0 | | | | | | |
| Sat 08/03/25 | Stockport Town v Pilkington | 2-1 | | | | | | |
| Sat 15/03/25 | FC Isle of Man v Pilkington | 3-3 | | | | | | |
| Sat 22/03/25 | Pilkington v Bury | 0-2 | | | | | | |
