| Sat 31/07/21 | Cammell Laird 1907 v Cheadle Heath Nomads * | 4-1 | | | | | |
| Sat 07/08/21 | Cheadle Heath Nomads v Abbey Hey | 2-3 | | | | | |
| Sat 14/08/21 | Cheadle Heath Nomads v West Didsbury & Chorlton | 2-2 | | | | | |
| Mon 16/08/21 | Stockport Town v Cheadle Heath Nomads | 2-3 | | | | | |
| Sat 21/08/21 | Cheadle Heath Nomads v FC Isle of Man | 2-2 | | | | | |
| Mon 30/08/21 | Cheadle Heath Nomads v Cheadle Town | 3-2 | | |  | | |
| Sat 04/09/21 | Eccleshall v Cheadle Heath Nomads | 2-2 | | | | | |
| Sat 11/09/21 | St Helens Town v Cheadle Heath Nomads | 0-4 | | | | | |
| Sat 18/09/21 | Abbey Hulton United v Cheadle Heath Nomads | 3-1 | | | | | |
| Tue 21/09/21 | Cheadle Heath Nomads v Brocton | 5-1 | | | | | |
| Sat 09/10/21 | Ellesmere Rangers v Cheadle Heath Nomads * | 3-3 | | | | | |
| Sat 16/10/21 | Alsager Town v Cheadle Heath Nomads | 3-4 | | | | | |
| Sat 23/10/21 | Cheadle Heath Nomads v St Martins * | 3-0 | | | | | |
| Sat 30/10/21 | Maine Road v Cheadle Heath Nomads | 3-1 | | | | | |
| Sat 06/11/21 | Wythenshawe Amateurs v Cheadle Heath Nomads * | 5-4 | | | | | |
| Sat 20/11/21 | Cheadle Heath Nomads v New Mills | 2-2 | | | | | |
| Sat 27/11/21 | Abbey Hey v Cheadle Heath Nomads | 1-2 | | | | | |
| Sat 04/12/21 | Stafford Town v Cheadle Heath Nomads | 3-3 | | | | | |
| Sat 11/12/21 | Cheadle Heath Nomads v Wythenshawe Amateurs | 1-4 | | | | | |
| Sat 18/12/21 | Cheadle Heath Nomads v Eccleshall * | 2-3 | | | | | |
| Sat 29/01/22 | Cheadle Heath Nomads v Cammell Laird 1907 * | 6-0 | | | | | |
| Sat 12/03/22 | Brocton v Cheadle Heath Nomads | 2-0 | | | | | |
| Wed 16/03/22 | Cheadle Town v Cheadle Heath Nomads * | 0-1 | | | | | |
| Tue 22/03/22 | Cheadle Heath Nomads v Abbey Hulton United | 0-4 | | | | | |
| Sat 26/03/22 | Cheadle Heath Nomads v Maine Road * | 4-1 | | | | | |
| Tue 29/03/22 | Cheadle Heath Nomads v Congleton Town | 2-3 | | | | | |
| Tue 05/04/22 | Cheadle Heath Nomads v New Mills | 2-1 | | | | | |
| Wed 13/04/22 | Cheadle Heath Nomads v New Mills | 6-1 | | | | | |
| Mon 18/04/22 | Ashton Town v Cheadle Heath Nomads | 0-0 | | | | | |
