| Tue 02/08/22 | Abbey Hey v Maine Road | 2-0 | | | | | |
| Mon 08/08/22 | Maine Road v Cammell Laird 1907 | 3-3 | | | | | |
| Sat 13/08/22 | New Mills v Maine Road | 1-2 | | | | | |
| Sat 20/08/22 | Ashville v Maine Road | 1-2 | | | | | |
| Sat 27/08/22 | Maine Road v Stafford Town | 4-1 | | | | | |
| Mon 05/09/22 | Maine Road v Alsager Town | 0-1 | | | | | |
| Tue 13/09/22 | Sandbach United v Maine Road | 0-2 | | | | | |
| Sat 17/09/22 | Maine Road v Rocester | 4-0 | | | | | |
| Sat 24/09/22 | Maine Road v Penistone Church | 1-1 | | | | | |
| Sat 01/10/22 | Maine Road v Abbey Hulton United | 1-0 |  | | | |  |
| Sat 08/10/22 | Maine Road v Barnton | 4-1 | | | | | |
| Sat 15/10/22 | Maine Road v Wythenshawe Amateurs * | 0-0 | | | | | |
| Sat 22/10/22 | Cheadle Heath Nomads v Maine Road | 1-1 | | | | | |
| Mon 24/10/22 | Maine Road v Irlam | 3-0 | | |  | | |
| Sat 29/10/22 | Stockport Georgians v Maine Road | 1-0 | | | | | |
| Sat 05/11/22 | Maine Road v Eccleshall | 1-0 | | | | | |
| Sat 12/11/22 | Cammell Laird 1907 v Maine Road | 4-3 | | | | | |
| Mon 14/11/22 | Maine Road v Ashton United | 0-4 | | | | | |
| Tue 22/11/22 | Cheadle Town v Maine Road | 1-3 | | | | | |
| Sat 03/12/22 | Maine Road v Stockport Georgians | 3-4 | | | | | |
| Tue 06/12/22 | Abbey Hulton United v Maine Road | 0-2 | | | | | |
| Mon 26/12/22 | Wythenshawe Amateurs v Maine Road | 3-0 | | | | | |
| Wed 04/01/23 | Eccleshall v Maine Road | 3-2 | | | | | |
| Sat 07/01/23 | Maine Road v Foley Meir | 3-3 | | | | | |
| Mon 16/01/23 | Maine Road v Abbey Hey | 0-2 | | | | | |
| Sat 28/01/23 | Alsager Town v Maine Road | 1-2 | | | | | |
| Sat 04/02/23 | Stockport Town v Maine Road | 1-0 | | | | | |
| Mon 06/02/23 | Maine Road v Cheadle Town | 1-3 | | | | | |
| Sat 11/02/23 | Maine Road v New Mills | 0-0 | | | | | |
| Sat 18/02/23 | Rocester v Maine Road | 1-2 | | | | | |
| Sat 04/03/23 | Foley Meir v Maine Road | 0-1 | | | | | |
| Mon 06/03/23 | Maine Road v Stockport Town | 0-4 | | | | | |
| Sat 11/03/23 | Barnton v Maine Road | 2-1 | | | | | |
| Sat 18/03/23 | Maine Road v Ellesmere Rangers | 1-0 | | | | | |
| Sat 25/03/23 | Maine Road v Brocton | 1-2 | | | | | |
| Mon 27/03/23 | Maine Road v Cheadle Heath Nomads | 2-2 | | | | | |
| Sat 01/04/23 | Stafford Town v Maine Road | 2-3 | | | | | |
| Mon 10/04/23 | Maine Road v Wythenshawe Amateurs | 1-0 | | | | | |
| Sat 15/04/23 | Maine Road v Sandbach United | 1-2 | | | | | |
