| Wed 24/09/25 | AFC Liverpool v Daisy Hill (CUP) * | 2-1 | | | | | | |
| Wed 01/10/25 | West Didsbury & Chorlton v AFC Liverpool * | 4-3 | | | | | | |
| Sat 04/10/25 | Atherton LR v AFC Liverpool * | 3-0 | | | | | | |
| Tue 07/10/25 | AFC Liverpool v Runcorn Town (CUP) | 3-3 |  | | | | | |
| Fri 10/10/25 | AFC Liverpool v Maghull (CUP) * | 3-1 | | | | | | |
| Tue 14/10/25 | Padiham v AFC Liverpool | 4-0 | | | | | | |
| Sat 18/10/25 | Barnoldswick Town v AFC Liverpool (CUP) | 1-0 | | | |  | | |
| Tue 21/10/25 | Charnock Richard v AFC Liverpool | 2-2 | | | | | |  |
| Sat 25/10/25 | Chadderton v AFC Liverpool | 0-1 | |  | | | | |
| Wed 05/11/25 | AFC Liverpool v Prestwich Heys * | 1-1 | | | | | | |
| Fri 07/11/25 | City of Liverpool v AFC Liverpool * | 1-3 | | | | | | |
| Tue 11/11/25 | Euxton Villa v AFC Liverpool * | 0-3 | | | | | | |
| Wed 19/11/25 | Cammell Laird 1907 v AFC Liverpool (CUP) | 1-3 | | | | | | |
| Sat 29/11/25 | AFC Liverpool v Cheadle Town | 2-2 | | | | | | |
| Sat 06/12/25 | AFC Liverpool v Abbey Hey | 3-0 | | | | | | |
| Wed 10/12/25 | AFC Liverpool v Wythenshawe | 1-5 | | | | |  | |
| Tue 16/12/25 | Glossop North End v AFC Liverpool | 1-1 | | | | | | |
| Sat 31/01/26 | AFC Liverpool v Glossop North End * | 2-2 | | | | | | |
| Tue 17/02/26 | AFC Liverpool v Euxton Villa (CUP) * | 3-0 | | | | | | |
| Sat 28/02/26 | Irlam v AFC Liverpool * | 1-0 | | | | | | |
| Wed 04/03/26 | AFC Liverpool v Padiham * | 0-2 | | | | | | |
| Sat 07/03/26 | AFC Liverpool v Barnoldswick Town * | 3-1 | | | | | | |
| Tue 10/03/26 | AFC Liverpool v Ramsbottom United | 0-2 | | | | | | |
| Thu 12/03/26 | Abbey Hey v AFC Liverpool | 0-1 | | | | | | |
| Sat 14/03/26 | South Liverpool v AFC Liverpool | 1-1 | | | | | | |
| Wed 18/03/26 | AFC Liverpool v Longridge Town | 2-0 | | | | | | |
