| Sat 02/08/25 | Colne v Maine Road | 3-2 | | | | | | |
| Sat 09/08/25 | Maine Road v MSB Woolton | 5-0 | |  | | | | |
| Sat 16/08/25 | Maine Road v Ashton Athletic | 4-0 | | | |  | | |
| Sat 23/08/25 | Crowle Colts v Maine Road (CUP) | 2-0 | | | | | | |
| Sat 13/09/25 | Maine Road v Thornton Cleveleys | 3-0 | | | | | | |
| Sat 20/09/25 | Maine Road v Steeton | 1-1 | | | | | | |
| Fri 26/09/25 | Droylsden v Maine Road (CUP) | 1-2 | | | | | | |
| Sat 04/10/25 | Maine Road v Bacup Borough | 0-1 | | | | | | |
| Sat 11/10/25 | Maine Road v Cheadle Town (CUP) | 1-2 | | | | | | |
| Sat 18/10/25 | Daisy Hill v Maine Road | 2-2 | | | | | | |
| Sat 25/10/25 | Holker Old Boys v Maine Road | 3-2 | | | | | |  |
| Wed 29/10/25 | Thornton Cleveleys v Maine Road (CUP) | 1-2 | | | | | | |
| Sat 01/11/25 | Maghull v Maine Road | 1-0 | | | | | | |
| Mon 10/11/25 | Maine Road v Ashton Town | 1-3 | | | | | | |
| Sat 15/11/25 | Maine Road v AFC Blackpool (CUP) | 0-0 | | | | | | |
| Sat 22/11/25 | Maine Road v Daisy Hill | 2-4 | | | | | | |
| Mon 24/11/25 | Maine Road v Bury (CUP) | 2-4 | | | | | | |
| Sat 29/11/25 | Garstang v Maine Road | 6-1 | | | | | | |
| Sat 13/12/25 | Maine Road v Squires Gate | 1-4 | | | | | | |
| Sat 31/01/26 | Nelson v Maine Road (CUP) | 1-1 | | | | | | |
| Mon 02/02/26 | Maine Road v Fulwood Amateurs | 3-1 | | | | | | |
| Sat 14/02/26 | Maine Road v Colne | 3-3 | | | | | | |
| Tue 17/02/26 | Fulwood Amateurs v Maine Road | 4-2 | | | | | | |
| Sat 21/02/26 | Maine Road v Darwen FC | 0-1 | | | | | | |
| Sat 28/02/26 | Ashton Athletic v Maine Road | 2-1 | | | | | | |
| Sat 07/03/26 | Maine Road v Holker Old Boys | 1-2 | | | | | | |
| Mon 09/03/26 | Maine Road v Nelson | 4-5 | | | | | | |
| Sat 21/03/26 | Maine Road v Maghull | 1-2 | | | | | | |
| Sat 28/03/26 | Steeton v Maine Road | 5-2 | | | | | | |
