| Tue 09/09/25 | Prestwich Heys v West Didsbury & Chorlton * | 2-1 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool * | 3-0 | |  | | | | |
| Sat 20/09/25 | Doncaster City v Prestwich Heys (CUP) * | 1-4 | | | | | | |
| Tue 23/09/25 | Prestwich Heys v Charnock Richard * | 3-3 | | | | | | |
| Tue 07/10/25 | FC St Helens v Prestwich Heys * | 0-2 | | | | | | |
| Sat 11/10/25 | Ramsbottom United v Prestwich Heys (CUP) * | 3-2 | | | | | | |
| Tue 14/10/25 | Prestwich Heys v Pilkington * | 2-0 | | | | | | |
| Sat 18/10/25 | Prestwich Heys v Maltby Main (CUP) * | 9-1 | | | | | | |
| Tue 21/10/25 | Abbey Hey v Prestwich Heys * | 2-1 | | | | | | |
| Sat 25/10/25 | Padiham v Prestwich Heys * | 0-2 | | | | | | |
| Tue 28/10/25 | Ramsbottom United v Prestwich Heys * | 3-0 | | | | | | |
| Sat 01/11/25 | Prestwich Heys v Ramsbottom United * | 0-3 | | | | | | |
| Wed 05/11/25 | AFC Liverpool v Prestwich Heys * | 1-1 | | | | | | |
| Sat 08/11/25 | Prestwich Heys v Irlam (CUP) * | 0-0 | | | | | | |
| Sat 22/11/25 | Prestwich Heys v Glossop North End * | 0-2 | | | | | | |
| Sat 13/12/25 | Winsford United v Prestwich Heys (CUP) * | 2-1 | | | | | | |
| Sat 31/01/26 | Wythenshawe v Prestwich Heys * | 1-1 | | | |  | | |
| Tue 03/02/26 | Prestwich Heys v Wythenshawe * | 1-2 | | | | | | |
| Tue 10/02/26 | Prestwich Heys v Euxton Villa * | 3-1 | | | | | | |
| Tue 17/02/26 | City of Liverpool v Prestwich Heys * | 0-7 | | | | | | |
| Sat 28/02/26 | Charnock Richard v Prestwich Heys * | 1-2 | | | | | | |
| Tue 03/03/26 | Prestwich Heys v Stockport Town | 1-0 | | | | | | |
| Sat 07/03/26 | Prestwich Heys v Litherland REMYCA * | 2-1 | | | | | | |
| Tue 10/03/26 | Prestwich Heys v Longridge Town * | 2-0 | | | | | | |
| Sat 14/03/26 | Prestwich Heys v City of Liverpool | 7-0 | | | | | | |
| Tue 17/03/26 | Prestwich Heys v Irlam * | 2-0 | | | | | | |
