| Sat 26/07/25 | South Liverpool v Stockport Town * | 0-3 | | | | | | |
| Tue 29/07/25 | Atherton LR v South Liverpool | 1-3 | | | | | | |
| Sat 02/08/25 | Bury v South Liverpool (CUP) | 6-0 | | | | | | |
| Sat 09/08/25 | Chadderton v South Liverpool | 7-2 | | | | | | |
| Wed 13/08/25 | South Liverpool v Litherland REMYCA | 2-1 |  | | |  | | |
| Sat 16/08/25 | Pilkington v South Liverpool | 1-6 | | | | | | |
| Wed 10/09/25 | South Liverpool v FC St Helens | 1-2 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool | 3-0 | | | | | | |
| Wed 17/09/25 | South Liverpool v Abbey Hey * | 5-3 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool * | 0-3 | |  | | | | |
| Sat 27/09/25 | AFC Liverpool v South Liverpool (CUP) | 3-1 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | | | | |
| Wed 15/10/25 | South Liverpool v Euxton Villa | 1-1 | | | | | | |
| Sat 25/10/25 | South Liverpool v Atherton LR * | 2-1 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool * | 1-1 | | | | | | |
| Sat 01/11/25 | Abbey Hey v South Liverpool * | 2-3 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard | 3-0 | | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam * | 0-3 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool * | 3-1 | | | | | | |
| Sat 29/11/25 | South Liverpool v Chadderton * | 2-3 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool | 3-1 | | | | | | |
| Sat 06/12/25 | Albion Sports v South Liverpool (CUP) | 0-3 | | | | | | |
| Wed 10/12/25 | Litherland REMYCA v South Liverpool (CUP) * | 1-4 | | | | | | |
| Sat 13/12/25 | Barnoldswick Town v South Liverpool | 0-0 | | | | | | |
