| Sat 06/09/25 | Stockport Town v Litherland REMYCA | 1-0 | | | | | | |
| Tue 09/09/25 | Longridge Town v Litherland REMYCA | 3-0 | | | | | | |
| Sat 13/09/25 | Litherland REMYCA v Glossop North End | 1-2 | | | | | | |
| Tue 16/09/25 | Atherton LR v Litherland REMYCA | 3-1 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | |  |
| Sat 27/09/25 | Litherland REMYCA v MSB Woolton (CUP) | 2-2 | | | | | | |
| Wed 08/10/25 | West Didsbury & Chorlton v Litherland REMYCA | 3-0 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man | 1-3 |  | | | | | |
| Wed 15/10/25 | Litherland REMYCA v Chadderton | 1-2 | | | | | | |
| Sat 18/10/25 | Padiham v Litherland REMYCA | 4-0 | | | | | | |
| Sat 25/10/25 | Litherland REMYCA v Wythenshawe | 1-2 | | | | | | |
| Wed 29/10/25 | Litherland REMYCA v Padiham | 2-3 | | | | | | |
| Sat 01/11/25 | Charnock Richard v Litherland REMYCA | 3-0 | | | | | | |
| Sat 22/11/25 | Litherland REMYCA v Stockport Town | 0-6 | | | | | | |
| Wed 26/11/25 | Litherland REMYCA v Prestwich Heys | 0-2 | | | | | | |
| Fri 28/11/25 | FC St Helens v Litherland REMYCA * | 1-0 | | | | | | |
| Wed 03/12/25 | Litherland REMYCA v Cheadle Town | 4-2 | | | | | | |
| Wed 10/12/25 | Litherland REMYCA v South Liverpool (CUP) | 1-4 | | | | | | |
| Sat 13/12/25 | Litherland REMYCA v Longridge Town | 0-2 | | | | | | |
| Sat 20/12/25 | Abbey Hey v Litherland REMYCA | 6-2 | | | | | | |
| Sat 27/12/25 | Litherland REMYCA v AFC Liverpool | 1-3 | | | | | | |
| Wed 14/01/26 | Litherland REMYCA v Euxton Villa | 1-3 | | | | | | |
| Sat 24/01/26 | Irlam v Litherland REMYCA * | 4-0 | | | | | | |
| Sat 31/01/26 | Barnoldswick Town v Litherland REMYCA | 2-2 | | | | | | |
