| Sat 26/07/25 | FC Isle of Man v Litherland REMYCA | 0-0 | |  | | | | |
| Tue 29/07/25 | FC St Helens v FC Isle of Man * | 2-0 | | | | | | |
| Sat 09/08/25 | FC Isle of Man v Glossop North End | 2-3 |  | | | | | |
| Tue 12/08/25 | Irlam v FC Isle of Man | 4-0 | | | | | | |
| Sat 16/08/25 | Abbey Hey v FC Isle of Man * | 1-2 | | | | | | |
| Sat 23/08/25 | Ramsbottom United v FC Isle of Man | 4-1 | | | | | | |
| Mon 25/08/25 | Wythenshawe v FC Isle of Man | 4-0 | | | | | | |
| Sat 06/09/25 | Burscough v FC Isle of Man * | 5-0 | | | | | | |
| Tue 09/09/25 | Cheadle Town v FC Isle of Man | 3-1 | | | | | | |
| Sat 13/09/25 | FC Isle of Man v Charnock Richard * | 3-2 | | | | | | |
| Tue 16/09/25 | AFC Liverpool v FC Isle of Man * | 5-1 | | | | | | |
| Sat 20/09/25 | Pilkington v FC Isle of Man | 0-0 | | | | | | |
| Sat 04/10/25 | FC Isle of Man v Barnoldswick Town | 1-2 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man | 1-3 | | | | | | |
| Sat 18/10/25 | FC Isle of Man v FC St Helens | 2-2 | | | | | | |
| Sat 25/10/25 | City of Liverpool v FC Isle of Man | 1-2 | | | | | | |
| Sat 01/11/25 | FC Isle of Man v Longridge Town | 2-2 | | | | | | |
| Tue 04/11/25 | Euxton Villa v FC Isle of Man | 3-3 | | | | | | |
| Sat 08/11/25 | FC Isle of Man v Pilkington | 1-2 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton * | 1-3 | | | | | | |
| Sat 22/11/25 | Longridge Town v FC Isle of Man | 2-5 | | | | | | |
| Sat 29/11/25 | Prestwich Heys v FC Isle of Man | 5-0 | | | | | | |
| Sat 06/12/25 | FC Isle of Man v Irlam | 2-2 | | | | | | |
| Sat 13/12/25 | FC Isle of Man v AFC Liverpool | 5-0 | | | | | | |
| Sat 20/12/25 | Glossop North End v FC Isle of Man | 2-3 | | | | | | |
