| Tue 13/08/24 | FC St Helens v FC Isle of Man * | 5-4 | | | | | | |
| Tue 10/09/24 | Ramsbottom United v FC Isle of Man | 1-2 |  | | | | | |
| Sat 14/09/24 | FC Isle of Man v Cheadle Town | 2-0 | |  | | | | |
| Wed 18/09/24 | South Liverpool v FC Isle of Man | 0-2 | | | | | | |
| Sat 21/09/24 | West Didsbury & Chorlton v FC Isle of Man | 2-1 | | | | | | |
| Tue 24/09/24 | Abbey Hey v FC Isle of Man | 1-2 | | | | | | |
| Sat 28/09/24 | Barnoldswick Town v FC Isle of Man | 1-3 | | | | | | |
| Sat 05/10/24 | FC Isle of Man v Ramsbottom United * | 0-1 | | | | | | |
| Wed 09/10/24 | Cheadle Town v FC Isle of Man | 4-0 | | | | | | |
| Sat 12/10/24 | FC Isle of Man v Padiham | 2-1 | | | | | | |
| Sat 19/10/24 | Longridge Town v FC Isle of Man | 1-3 | | | | | | |
| Sat 26/10/24 | Chadderton v FC Isle of Man | 1-2 | | | | | |  |
| Sat 02/11/24 | FC Isle of Man v Abbey Hey | 3-1 | | | | | | |
| Sat 09/11/24 | Squires Gate v FC Isle of Man | 0-3 | | | | | | |
| Sat 16/11/24 | FC Isle of Man v Burscough | 3-2 | | | |  | | |
| Sat 23/11/24 | Pilkington v FC Isle of Man | 3-3 | | | | | | |
| Sat 30/11/24 | AFC Liverpool v FC Isle of Man * | 2-1 | | | | | | |
| Sat 14/12/24 | FC Isle of Man v Stockport Town | 1-2 | | | | | | |
| Sat 21/12/24 | Lower Breck v FC Isle of Man * | 3-0 | | | | | | |
| Sat 28/12/24 | FC Isle of Man v FC St Helens | 3-2 | | | | | | |
| Sat 04/01/25 | FC Isle of Man v Glossop North End | 0-2 | | | | | | |
| Sat 18/01/25 | Padiham v FC Isle of Man * | 2-1 | | | | | | |
| Sat 25/01/25 | FC Isle of Man v AFC Liverpool * | 2-1 | | | | | | |
| Sat 01/02/25 | FC Isle of Man v Irlam | 1-1 | | | | | | |
| Sat 22/02/25 | FC Isle of Man v Colne * | 1-1 | | | | | | |
| Sat 01/03/25 | Burscough v FC Isle of Man * | 2-1 | | | | | | |
| Sun 16/03/25 | FC Isle of Man v Prestwich Heys | 2-2 | | | | | | |
