| Sat 26/07/25 | Padiham v Wythenshawe | 3-0 |  |  | | | | |
| Tue 29/07/25 | Prestwich Heys v Padiham | 0-2 | | | | | | |
| Sat 02/08/25 | Penistone Church v Padiham (CUP) | 1-4 | | | | | | |
| Sat 09/08/25 | Stockport Town v Padiham | 1-2 | | | | | | |
| Tue 12/08/25 | Padiham v Euxton Villa | 2-0 | | | | | | |
| Sat 16/08/25 | Congleton Town v Padiham (CUP) | 3-0 | | | | | | |
| Sat 23/08/25 | Padiham v Sunderland RCA (CUP) * | 2-2 | | | | | | |
| Mon 25/08/25 | Padiham v Ramsbottom United | 3-1 | | | |  | |  |
| Sat 30/08/25 | FC Isle of Man v Padiham | 2-3 | | | | | | |
| Tue 09/09/25 | Padiham v Glossop North End * | 3-1 | | | | | | |
| Sat 13/09/25 | Padiham v City of Liverpool | 0-2 | | | | | | |
| Tue 16/09/25 | Charnock Richard v Padiham | 2-2 | | | | | | |
| Sun 21/09/25 | Campion v Padiham (CUP) | 3-1 | | | | | | |
| Tue 23/09/25 | Padiham v Burscough | 3-0 | | | | | | |
| Tue 07/10/25 | Padiham v Longridge Town | 4-1 | | | | | | |
| Sat 11/10/25 | Padiham v Nelson (CUP) | 0-6 | | | | | | |
| Tue 14/10/25 | Padiham v AFC Liverpool | 4-0 | | | | | | |
| Sat 18/10/25 | Padiham v Litherland REMYCA | 4-0 | | | | | | |
| Tue 21/10/25 | Chadderton v Padiham | 2-3 | | | | | | |
| Sat 25/10/25 | Padiham v Prestwich Heys | 0-2 | | | | | | |
| Wed 29/10/25 | Litherland REMYCA v Padiham | 2-3 | | | | | | |
| Sat 01/11/25 | Irlam v Padiham | 2-0 | | | | | | |
| Tue 04/11/25 | Padiham v Abbey Hey | 4-1 | | | | | | |
| Sat 08/11/25 | FC St Helens v Padiham | 1-1 | | | | | | |
| Tue 11/11/25 | Padiham v Charnock Richard | - | | | | | | |
| Sat 22/11/25 | Pilkington v Padiham | 1-10 | | | | | | |
| Sat 29/11/25 | Burscough v Padiham | 0-2 | | | | | | |
| Sat 06/12/25 | Padiham v Cheadle Town | 1-4 | | | | | | |
| Sat 13/12/25 | City of Liverpool v Padiham | 0-3 | | | | | | |
| Sat 20/12/25 | South Liverpool v Padiham | 1-0 | | | | | | |
| Fri 26/12/25 | Padiham v Barnoldswick Town | 3-1 | | | | | | |
