| Sat 27/07/24 | FC St Helens v Abbey Hey | 3-0 | |  | |  | | |
| Wed 31/07/24 | Cheadle Town v FC St Helens | 1-3 |  | | | | |  |
| Sun 04/08/24 | Emley v FC St Helens (CUP) * | 1-0 | | | | | | |
| Sat 10/08/24 | FC St Helens v Ramsbottom United * | 0-3 | | | | | | |
| Tue 13/08/24 | FC St Helens v FC Isle of Man * | 5-4 | | | | | | |
| Sat 17/08/24 | FC St Helens v Lower Breck * | 1-1 | | | | | | |
| Sat 24/08/24 | FC St Helens v Cheadle Heath Nomads (CUP) | 2-1 | | | | | | |
| Tue 27/08/24 | FC St Helens v Prestwich Heys | 4-2 | | | | | | |
| Sat 31/08/24 | FC St Helens v Stockport Town | 4-1 | | | | | | |
| Tue 03/09/24 | AFC Liverpool v FC St Helens | 1-2 | | | | | | |
| Sat 07/09/24 | FC St Helens v Litherland REMYCA | 2-1 | | | | | | |
| Sat 14/09/24 | Charnock Richard v FC St Helens | 2-2 | | | | | | |
| Tue 17/09/24 | FC St Helens v Burscough * | 2-2 | | | | | | |
| Sat 21/09/24 | Stockport Town v FC St Helens (CUP) * | 2-1 | | | | | | |
| Tue 24/09/24 | FC St Helens v West Didsbury & Chorlton | 0-1 | | |  | | | |
| Tue 08/10/24 | FC St Helens v Litherland REMYCA (CUP) | 2-1 | | | | | | |
| Sat 12/10/24 | Prestwich Heys v FC St Helens | 0-3 | | | | | | |
| Wed 16/10/24 | South Liverpool v FC St Helens | 1-1 | | | | | | |
| Tue 22/10/24 | Padiham v FC St Helens | 3-3 | | | | | | |
| Sat 26/10/24 | West Didsbury & Chorlton v FC St Helens | 3-1 | | | | | | |
| Tue 29/10/24 | FC St Helens v Irlam * | 0-1 | | | | | | |
| Fri 01/11/24 | FC St Helens v Chadderton * | 1-0 | | | | | | |
| Tue 05/11/24 | Bury v FC St Helens * | 1-1 | | | | | | |
| Sat 09/11/24 | FC St Helens v Barnoldswick Town | 0-1 | | | | | | |
| Tue 12/11/24 | FC St Helens v Glossop North End | 1-1 | | | | | | |
| Sat 16/11/24 | Squires Gate v FC St Helens * | 2-3 | | | | | | |
