| Sat 30/07/22 | Ashton Athletic v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 02/08/22 | West Didsbury & Chorlton v Prestwich Heys | 2-1 | | | | |  |
| Sat 06/08/22 | Longridge Town v West Didsbury & Chorlton | 0-1 | | | | | |
| Tue 09/08/22 | Congleton Town v West Didsbury & Chorlton | 1-1 | | | | | |
| Sat 13/08/22 | West Didsbury & Chorlton v Barnoldswick Town | 5-2 | | | | | |
| Tue 16/08/22 | Vauxhall Motors v West Didsbury & Chorlton | 2-0 | | | | | |
| Fri 19/08/22 | Northwich Victoria v West Didsbury & Chorlton | 2-3 | | | | | |
| Tue 23/08/22 | West Didsbury & Chorlton v Irlam | 1-1 | | | | | |
| Sat 27/08/22 | West Didsbury & Chorlton v Ashton Town | 3-1 | | | | | |
| Mon 29/08/22 | Winsford United v West Didsbury & Chorlton | 0-2 | | | | | |
| Sat 03/09/22 | West Didsbury & Chorlton v Macclesfield | 0-1 | | | | | |
| Wed 14/09/22 | Northwich Victoria v West Didsbury & Chorlton | 2-1 | | | | | |
| Sat 17/09/22 | Longridge Town v West Didsbury & Chorlton | 0-8 | | | | | |
| Wed 21/09/22 | Garstang v West Didsbury & Chorlton | 2-3 | | | | | |
| Sat 24/09/22 | West Didsbury & Chorlton v Nostell Miners Welfare | 2-1 | | | | | |
| Tue 27/09/22 | Burscough v West Didsbury & Chorlton | 1-6 | | | | | |
| Sat 01/10/22 | Padiham v West Didsbury & Chorlton | 2-3 | | | | | |
| Tue 04/10/22 | West Didsbury & Chorlton v Lower Breck | 1-4 | | | | | |
| Sat 08/10/22 | West Didsbury & Chorlton v Congleton Town | 3-2 | | | | | |
| Tue 11/10/22 | West Didsbury & Chorlton v FC Isle of Man | 2-1 | | | | | |
| Sat 15/10/22 | Pilkington v West Didsbury & Chorlton | 3-0 | | | | | |
| Tue 18/10/22 | Glossop North End v West Didsbury & Chorlton | 2-1 | | | | | |
| Sat 22/10/22 | West Didsbury & Chorlton v Golcar United | 2-1 | | | | | |
| Tue 25/10/22 | West Didsbury & Chorlton v Bury AFC | 0-3 | | | | | |
| Sat 05/11/22 | Avro v West Didsbury & Chorlton | 3-0 | | | | | |
| Tue 08/11/22 | Barnoldswick Town v West Didsbury & Chorlton | 2-1 | | | | | |
| Sat 12/11/22 | Bacup Borough v West Didsbury & Chorlton | 2-2 | | | | | |
| Sat 19/11/22 | West Didsbury & Chorlton v Padiham | 3-0 | | | | | |
| Tue 22/11/22 | West Didsbury & Chorlton v Litherland REMYCA | 2-1 | | | | | |
| Sat 26/11/22 | West Didsbury & Chorlton v Squires Gate | 1-1 | | | | | |
| Sat 03/12/22 | Whitley Bay v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 06/12/22 | West Didsbury & Chorlton v AFC Blackpool | 1-0 | | | | | |
| Tue 20/12/22 | West Didsbury & Chorlton v Ashton Athletic | 4-1 | | | | | |
| Mon 26/12/22 | West Didsbury & Chorlton v Charnock Richard | 2-2 | | | | | |
| Sat 07/01/23 | AFC Liverpool v West Didsbury & Chorlton | 5-3 | | | | | |
| Sat 14/01/23 | West Didsbury & Chorlton v Horden Community Welfare | 2-0 | | | | | |
| Tue 24/01/23 | West Didsbury & Chorlton v Atherton Collieries | 0-6 | | | | | |
| Sat 28/01/23 | Irlam v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 31/01/23 | Wythenshawe Town v West Didsbury & Chorlton | 0-3 | | | | | |
| Sat 04/02/23 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | |
| Sat 11/02/23 | Coventry Sphinx v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 14/02/23 | West Didsbury & Chorlton v Northwich Victoria | 1-1 | | | | | |
| Sat 18/02/23 | West Didsbury & Chorlton v AFC Liverpool | 3-0 | | | | | |
| Tue 21/02/23 | Bury AFC v West Didsbury & Chorlton | 0-0 | | | | | |
| Sat 25/02/23 | West Didsbury & Chorlton v Wythenshawe Town | 0-2 | | | | | |
| Tue 28/02/23 | West Didsbury & Chorlton v Kendal Town | 3-2 | | | | | |
| Sat 04/03/23 | Squires Gate v West Didsbury & Chorlton | 1-3 | | | | | |
| Sat 11/03/23 | West Didsbury & Chorlton v Ascot United | 1-1 | | | | | |
| Sat 18/03/23 | West Didsbury & Chorlton v Winsford United | 1-1 | | | | | |
| Sat 25/03/23 | FC Isle of Man v West Didsbury & Chorlton | 2-2 | | | | | |
| Sat 01/04/23 | Kendal Town v West Didsbury & Chorlton | 0-2 | | |  | | |
| Tue 04/04/23 | West Didsbury & Chorlton v Avro | 1-1 | | | | | |
| Thu 06/04/23 | Prestwich Heys v West Didsbury & Chorlton | 2-1 | | | | | |
| Mon 10/04/23 | Charnock Richard v West Didsbury & Chorlton | 5-1 | | | | | |
| Thu 13/04/23 | Lower Breck v West Didsbury & Chorlton | 1-1 | | | | | |
| Sat 15/04/23 | West Didsbury & Chorlton v Longridge Town | 2-2 | | | | | |
| Wed 19/04/23 | Litherland REMYCA v West Didsbury & Chorlton | 4-1 | | | | | |
| Sat 22/04/23 | West Didsbury & Chorlton v Vauxhall Motors | 0-2 | | | | | |
