| Sat 26/07/25 | Droylsden v AFC Blackpool | 2-0 | | | |  | |  |
| Sat 02/08/25 | Nelson v AFC Blackpool | 2-1 |  | | | | | |
| Sat 09/08/25 | AFC Blackpool v Maghull | 1-2 | | | | | | |
| Sat 23/08/25 | Fulwood Amateurs v AFC Blackpool (CUP) | 1-1 | | | | | | |
| Sat 30/08/25 | Darwen FC v AFC Blackpool | 0-2 | |  | | | | |
| Sat 06/09/25 | AFC Blackpool v Maine Road | 2-0 | | | | | | |
| Sat 13/09/25 | AFC Blackpool v Garstang | 1-1 | | | | | | |
| Sat 20/09/25 | Ashton Town v AFC Blackpool | - | | | | | | |
| Sat 27/09/25 | Bacup Borough v AFC Blackpool (CUP) | 0-0 | | | | | | |
| Wed 01/10/25 | AFC Blackpool v Ashton Town | 3-0 | | | | | | |
| Sat 25/10/25 | AFC Blackpool v MSB Woolton | 2-1 | | | | | | |
| Tue 28/10/25 | Droylsden v AFC Blackpool (CUP) | 1-3 | | | | | | |
| Sat 01/11/25 | AFC Blackpool v Steeton | 1-0 | | | | | | |
| Sat 08/11/25 | AFC Blackpool v Ashton Athletic | 2-0 | | | | | | |
| Tue 11/11/25 | Colne v AFC Blackpool | - | | | | | | |
| Sat 15/11/25 | Maine Road v AFC Blackpool (CUP) | 0-0 | | | | | | |
| Sat 22/11/25 | Burscough v AFC Blackpool (CUP) | 3-1 | | | | | | |
| Sat 29/11/25 | AFC Blackpool v Colne | 2-2 | | | | | | |
| Mon 01/12/25 | Daisy Hill v AFC Blackpool | - | | | | | | |
| Sat 13/12/25 | AFC Blackpool v Thornton Cleveleys | 2-2 | | | | | | |
| Tue 16/12/25 | Colne v AFC Blackpool | - | | | | | | |
| Sat 20/12/25 | Ashton Athletic v AFC Blackpool | 1-2 | | | | | | |
| Fri 26/12/25 | Squires Gate v AFC Blackpool | 3-1 | | | | | | |
| Sat 03/01/26 | AFC Blackpool v Bacup Borough * | 2-0 | | | | | | |
| Sat 10/01/26 | Maghull v AFC Blackpool * | 2-2 | | | | | | |
| Mon 19/01/26 | Maine Road v AFC Blackpool * | 2-1 | | | | | | |
| Sat 24/01/26 | Fulwood Amateurs v AFC Blackpool | 4-0 | | | | | | |
| Tue 27/01/26 | Colne v AFC Blackpool | 5-1 | | | | | | |
| Sat 31/01/26 | Steeton v AFC Blackpool | 3-1 | | | | | | |
| Mon 02/02/26 | Daisy Hill v AFC Blackpool | 4-1 | | | | | | |
