| Sat 26/07/25 | South Liverpool v Stockport Town | 0-3 | | | |  | |  |
| Tue 29/07/25 | Atherton LR v South Liverpool | 1-3 |  | | | | | |
| Sat 02/08/25 | Bury v South Liverpool (CUP) | 6-0 | | | | | | |
| Sat 09/08/25 | Chadderton v South Liverpool | 7-2 | | | | | | |
| Wed 13/08/25 | South Liverpool v Litherland REMYCA | 2-1 | | | | | | |
| Sat 16/08/25 | Pilkington v South Liverpool | 1-6 | | | | | | |
| Mon 25/08/25 | South Liverpool v Burscough | 0-3 | | | | | | |
| Sat 30/08/25 | Glossop North End v South Liverpool | 0-1 | |  | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | | | | | | |
| Wed 10/09/25 | South Liverpool v FC St Helens * | 1-2 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool * | 3-0 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool * | 0-3 | | | | | | |
| Sat 27/09/25 | AFC Liverpool v South Liverpool (CUP) * | 3-1 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man * | 3-1 | | | | | | |
| Sat 11/10/25 | Longridge Town v South Liverpool * | 1-1 | | | | | | |
| Wed 15/10/25 | South Liverpool v Euxton Villa | 1-1 | | | | | | |
| Sat 18/10/25 | Northallerton Town v South Liverpool (CUP) | 1-2 | | | | | | |
| Sat 25/10/25 | South Liverpool v Atherton LR | 2-1 | | | | | | |
| Sat 01/11/25 | Abbey Hey v South Liverpool * | 2-3 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard * | 3-0 | | | | | | |
| Sat 08/11/25 | South Liverpool v Barton Town (CUP) * | 4-0 | | | | | | |
| Wed 10/12/25 | Litherland REMYCA v South Liverpool (CUP) * | 1-4 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool * | 5-2 | | | | | | |
| Sat 07/02/26 | South Liverpool v Longridge Town * | 2-2 | | | | | | |
| Tue 10/02/26 | City of Liverpool v South Liverpool | 1-2 | | | | | | |
