| Sat 30/08/25 | Litherland REMYCA v Irlam * | 0-3 | |  | |  | | |
| Sat 06/09/25 | Irlam v Prestwich Heys * | 2-1 | | | | | | |
| Tue 09/09/25 | City of Liverpool v Irlam | - | | | | | | |
| Tue 16/09/25 | Irlam v West Didsbury & Chorlton * | 2-4 | | | | | | |
| Sat 20/09/25 | Irlam v Bacup Borough (CUP) * | 2-0 | | | | | | |
| Tue 23/09/25 | Irlam v Wythenshawe | 0-2 | | | | | |  |
| Sat 27/09/25 | Irlam v Ramsbottom United | 3-2 | | | | | | |
| Sat 04/10/25 | Stockport Town v Irlam * | 0-3 | | | | | | |
| Tue 07/10/25 | Irlam v Atherton LR * | 3-0 | | | | | | |
| Tue 14/10/25 | FC St Helens v Irlam * | 2-2 | | | | | | |
| Wed 29/10/25 | West Didsbury & Chorlton v Irlam * | 2-5 | | | | | | |
| Sat 01/11/25 | Irlam v Padiham * | 2-0 | | | | | | |
| Tue 18/11/25 | Radcliffe v Irlam (CUP) | 5-2 | | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam * | 0-3 | | | | | | |
| Tue 25/11/25 | Atherton LR v Irlam | 1-4 | | | | | | |
| Tue 02/12/25 | Irlam v Chadderton | 2-4 | | | | | | |
| Sat 06/12/25 | FC Isle of Man v Irlam | 2-2 |  | | | | | |
| Sat 13/12/25 | Irlam v FC St Helens | 4-1 | | | | | | |
| Sat 20/12/25 | Burscough v Irlam | 3-0 | | | | | | |
| Fri 26/12/25 | Irlam v Glossop North End * | 0-1 | | | | | | |
| Tue 13/01/26 | Irlam v Cheadle Town | 6-0 | | | | | | |
| Sat 17/01/26 | Abbey Hey v Irlam | 1-3 | | | | | | |
| Tue 20/01/26 | Ramsbottom United v Irlam | 2-2 | | | | | | |
| Sat 24/01/26 | Irlam v Litherland REMYCA * | 4-0 | | | | | | |
| Sat 31/01/26 | Irlam v City of Liverpool | 4-1 | | | | | | |
| Tue 03/02/26 | Irlam v Abbey Hey | 3-2 | | | | | | |
| Tue 10/02/26 | Barnoldswick Town v Irlam | 0-3 | | | | | | |
| Tue 24/02/26 | City of Liverpool v Irlam | 0-6 | | | | | | |
| Sat 28/02/26 | Irlam v AFC Liverpool | 1-0 | | | | | | |
| Tue 03/03/26 | Irlam v South Liverpool * | 0-2 | | | | | | |
| Sat 07/03/26 | Pilkington v Irlam | 1-2 | | | | | | |
| Tue 10/03/26 | Irlam v Stockport Town * | 0-0 | | | | | | |
| Sat 28/03/26 | Irlam v Longridge Town * | 4-1 | | | | | | |
| Sat 04/04/26 | Chadderton v Irlam * | 1-2 | | | | | | |
| Mon 06/04/26 | Glossop North End v Irlam * | 2-1 | | | | | | |
| Sat 11/04/26 | Irlam v Burscough | 2-1 | | | | | | |
