| Sat 26/07/25 | Burscough v Abbey Hey | 1-1 | | | |  | |  |
| Tue 29/07/25 | Burscough v AFC Liverpool | 1-1 | | | | | | |
| Sat 02/08/25 | Charnock Richard v Burscough (CUP) | 1-0 | | | | | | |
| Sat 23/08/25 | Burscough v MSB Woolton (CUP) | 4-2 | | | | | | |
| Mon 25/08/25 | South Liverpool v Burscough | 0-3 | |  | | | | |
| Sat 30/08/25 | Burscough v FC St Helens | 1-2 | | | | | | |
| Sat 06/09/25 | Burscough v FC Isle of Man | 5-0 | | | | | | |
| Tue 09/09/25 | Euxton Villa v Burscough | 0-1 | | | | | | |
| Sat 13/09/25 | Burscough v Cheadle Town | 0-1 | | | | | | |
| Tue 16/09/25 | Ramsbottom United v Burscough | 2-0 | | | | | | |
| Sat 20/09/25 | Sheffield v Burscough (CUP) | 2-2 | | | | | | |
| Tue 23/09/25 | Padiham v Burscough | 3-0 | | | | | | |
| Sat 27/09/25 | Daisy Hill v Burscough (CUP) | 0-0 | | | | | | |
| Tue 07/10/25 | Burscough v Pilkington | 3-1 | | | | | | |
| Sat 11/10/25 | Atherton LR v Burscough (CUP) | 1-1 | | | | | | |
| Tue 14/10/25 | Burscough v Ashton Town (CUP) | 3-1 | | | | | | |
| Sat 18/10/25 | Burscough v Billingham Synthonia (CUP) | 6-0 | | | | | | |
| Tue 21/10/25 | Burscough v Euxton Villa | 3-0 | | | | | | |
| Sat 25/10/25 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | | |
| Tue 28/10/25 | Chadderton v Burscough | 1-0 | | | | | | |
| Sat 01/11/25 | Barnoldswick Town v Burscough | 1-2 | | | | | | |
| Mon 03/11/25 | Stockport Town v Burscough | 1-3 | | | | | | |
| Sat 03/01/26 | Pilkington v Burscough | 2-6 | | | | | | |
| Sat 10/01/26 | FC Isle of Man v Burscough | 0-1 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool | 5-2 | | | | | | |
| Sat 17/01/26 | Cheadle Town v Burscough | 0-0 | | | | | | |
| Tue 20/01/26 | Burscough v Charnock Richard | 3-1 | | | | | | |
| Sat 24/01/26 | Burscough v Prestwich Heys | 1-1 | | | | | | |
