| Wed 30/07/25 | Litherland REMYCA v City of Liverpool * | 2-0 | | | | | | |
| Sat 02/08/25 | City of Liverpool v Euxton Villa (CUP) * | 2-1 | | | | | | |
| Sat 09/08/25 | City of Liverpool v Atherton LR * | 0-6 | | | | | | |
| Sun 17/08/25 | Hallam v City of Liverpool (CUP) | 3-0 | | | |  | | |
| Sat 30/08/25 | AFC Liverpool v City of Liverpool | 3-4 | | | | | | |
| Sat 06/09/25 | Charnock Richard v City of Liverpool | 4-2 | | | | | | |
| Sat 13/09/25 | Padiham v City of Liverpool | 0-2 |  |  | | | | |
| Tue 16/09/25 | City of Liverpool v Pilkington | 3-4 | | | | | | |
| Sat 20/09/25 | City of Liverpool v Charnock Richard (CUP) | 0-1 | | | | | | |
| Tue 23/09/25 | City of Liverpool v FC St Helens | 1-2 | | | | | | |
| Tue 30/09/25 | City of Liverpool v Longridge Town | 2-2 | | | | | | |
| Sat 04/10/25 | Burscough v City of Liverpool | 2-1 | | | | | | |
| Sat 18/10/25 | Pilkington v City of Liverpool * | 1-3 | | | | | | |
| Mon 20/10/25 | Stockport Town v City of Liverpool * | 0-2 | | | | | | |
| Sat 01/11/25 | City of Liverpool v Euxton Villa | 0-0 | | | | | | |
| Fri 07/11/25 | City of Liverpool v AFC Liverpool | 1-3 | | | | | | |
| Sat 29/11/25 | Barnoldswick Town v City of Liverpool | 7-0 | | | | | | |
| Sat 06/12/25 | City of Liverpool v Wythenshawe | 1-2 | | | | | | |
| Sat 13/12/25 | City of Liverpool v Padiham | 0-3 | | | | | | |
| Tue 16/12/25 | City of Liverpool v Chadderton | 0-9 | | | | | | |
| Sat 17/01/26 | City of Liverpool v Charnock Richard | 0-8 | | | | | | |
| Tue 20/01/26 | FC St Helens v City of Liverpool | 1-0 | | | | | |  |
| Sat 24/01/26 | Ramsbottom United v City of Liverpool | 1-0 | | | | | | |
| Tue 27/01/26 | City of Liverpool v Burscough | 1-7 | | | | | | |
| Sat 31/01/26 | Irlam v City of Liverpool | 4-1 | | | | | | |
| Tue 17/02/26 | City of Liverpool v Prestwich Heys | - | | | | | | |
