| Sat 13/09/25 | West Didsbury & Chorlton v Barnoldswick Town | 4-0 | |  | | | | |
| Tue 16/09/25 | Irlam v West Didsbury & Chorlton | 2-4 | | | | | | |
| Sat 20/09/25 | West Didsbury & Chorlton v Glossop North End | 1-2 | | | | | | |
| Tue 23/09/25 | Chadderton v West Didsbury & Chorlton | 1-3 | | | | | | |
| Wed 01/10/25 | West Didsbury & Chorlton v AFC Liverpool | 4-3 | | | | | | |
| Sat 04/10/25 | West Didsbury & Chorlton v Longridge Town | 3-0 |  | | | | | |
| Wed 08/10/25 | West Didsbury & Chorlton v Litherland REMYCA | 3-0 | | | | | | |
| Sat 11/10/25 | West Didsbury & Chorlton v Abbey Hey (CUP) * | 4-0 | | | |  | | |
| Tue 14/10/25 | Charnock Richard v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 18/10/25 | Atherton LR v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 25/10/25 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | | |
| Wed 29/10/25 | West Didsbury & Chorlton v Irlam | 2-5 | | | | | | |
| Sat 01/11/25 | Pilkington v West Didsbury & Chorlton * | 0-5 | | | | | | |
| Tue 04/11/25 | Cheadle Town v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 08/11/25 | Brigg Town v West Didsbury & Chorlton (CUP) * | 1-2 | | | | | | |
| Wed 12/11/25 | West Didsbury & Chorlton v City of Liverpool | 6-1 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton | 1-3 | | | | | | |
| Wed 26/11/25 | West Didsbury & Chorlton v Stalybridge Celtic (CUP) | 3-1 | | | | | | |
| Sat 29/11/25 | West Didsbury & Chorlton v Charnock Richard | - | | | | | | |
| Wed 03/12/25 | West Didsbury & Chorlton v Stockport Town | 1-3 | | | | | | |
| Fri 12/12/25 | Abbey Hey v West Didsbury & Chorlton * | 1-2 | | | | | | |
| Sat 20/12/25 | West Didsbury & Chorlton v Chadderton | - | | | | | | |
| Fri 26/12/25 | West Didsbury & Chorlton v Wythenshawe * | 0-1 | | | | | | |
| Sat 10/01/26 | FC St Helens v West Didsbury & Chorlton | - | | | | | | |
| Wed 14/01/26 | West Didsbury & Chorlton v Charnock Richard * | 1-4 | | | | | | |
| Sat 17/01/26 | West Didsbury & Chorlton v Nelson (CUP) | 1-0 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man * | 3-2 | | | | | | |
| Wed 04/02/26 | West Didsbury & Chorlton v Chadderton * | 2-3 | | | | | | |
| Tue 10/02/26 | Padiham v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 14/02/26 | West Didsbury & Chorlton v Winsford United (CUP) | 4-1 | | | | | | |
