| Sat 30/07/22 | Atherton LR v FC St Helens * | 1-1 | | |  | | |
| Sat 06/08/22 | FC St Helens v Darwen FC * | 5-1 | | | | | |
| Tue 09/08/22 | Runcorn Town v FC St Helens * | 0-4 | | | | | |
| Sat 13/08/22 | FC St Helens v Ilkley Town | 0-0 | | | | | |
| Sat 20/08/22 | FC St Helens v Bacup Borough * | 1-2 | | | | | |
| Sat 17/09/22 | Darwen FC v FC St Helens * | 1-2 | | | | | |
| Sat 24/09/22 | FC St Helens v Rossington Main | 2-1 | | | | | |
| Sat 01/10/22 | FC St Helens v Steeton | 2-0 | | | | | |
| Tue 04/10/22 | FC St Helens v South Liverpool | 2-1 |  | | | | |
| Sat 08/10/22 | AFC Blackpool v FC St Helens * | 1-1 | | | | | |
| Sat 15/10/22 | FC St Helens v AFC Blackpool * | 2-1 | | | | | |
| Sat 22/10/22 | FC St Helens v Penistone Church | 2-1 | | | | | |
| Sat 29/10/22 | FC St Helens v Ashton Town | 6-0 | | | | | |
| Sat 05/11/22 | FC St Helens v Daisy Hill * | 2-0 | | | | | |
| Tue 06/12/22 | FC St Helens v Garstang | 1-1 | | | | | |
| Tue 20/12/22 | FC St Helens v Darwen FC | 1-1 | | | | | |
| Mon 26/12/22 | Pilkington v FC St Helens | 1-1 | | | | | |
| Sat 07/01/23 | Steeton v FC St Helens | 1-3 | | | | | |
| Sat 14/01/23 | FC St Helens v Chadderton | 1-1 | | | | | |
| Tue 24/01/23 | FC St Helens v Nelson * | 3-1 | | | | | |
| Thu 26/01/23 | FC St Helens v Euxton Villa * | 4-0 | | | | | |
| Sat 04/02/23 | Daisy Hill v FC St Helens * | 0-2 | | | | | |
| Tue 07/02/23 | Chadderton v FC St Helens | 1-1 | | | | | |
| Sat 11/02/23 | FC St Helens v AFC Blackpool * | 2-0 | | | | | |
| Wed 15/02/23 | Bacup Borough v FC St Helens | 2-3 | | | | | |
| Sat 18/02/23 | FC St Helens v Squires Gate | 2-0 | | | | | |
| Tue 21/02/23 | Nelson v FC St Helens * | 2-2 | | | | | |
| Fri 03/03/23 | FC St Helens v Runcorn Town * | 1-0 | | | | | |
| Tue 07/03/23 | Euxton Villa v FC St Helens | 1-1 | | | | | |
| Sat 18/03/23 | AFC Blackpool v FC St Helens | 4-2 | | | | | |
| Tue 21/03/23 | FC St Helens v Atherton LR * | 2-2 | | | | | |
